Aletris - Estradiol Interaction
Herbal: Aletris
Also Known As: Aletris farinosa, Ague, Ague Grass, Ague Root, Aloerot, Blazing Star, Colic Root, Crow Corn, Devil's-bit, Licorne Vraie, Stargrass, Starwort, True Unicorn Root, Unicorn Root, Whitetube Stargrass
Drug: Estradiol
Brand names:
Estrace, Gynodiol, Vagifem, Estring, Vivelle, Estraderm, Divigel, Evamist, Elestrin, Minivelle, Imvexxy, Oestrogel
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Apr 20, 2025
Interaction Details
Estradiol is classified as belonging to the following category: Estrogens
Aletris might have estrogenic effects. Theoretically, use of aletris with estrogens might increase the risk for additive adverse effects.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
Aletris Overview
Aletris farinosa, commonly known as True Unicorn Root or Colic Root, is a perennial herb native to North America. The plant is characterized by its slender, erect stem and narrow leaves, with small, white flowers clustered at the top. The part of aletris used for its medicinal properties is the root, which contains a variety of compounds including a cheilanthane sesterterpene. This herb has been traditionally employed for addressing menstrual complaints, with some of its constituents believed to possess estrogenic activity.
Estradiol Overview
-
Vaginal estrogen is used to treat vaginal dryness, itching, and burning; painful or difficult urination; and sudden need to urinate immediately in women who are experiencing or have experienced menopause (change of life; the end of monthly menstrual periods). Femring® brand vaginal ring is also used to treat hot flushes ('hot flashes'; sudden strong feelings of heat and sweating) in women who are experiencing menopause. Premarin® brand vaginal cream is also used to treat kraurosis vulvae (a condition that may cause vaginal dryness and discomfort in women or girls of any age). Imvexxy® brand vaginal inserts are used for the treatment of dyspareunia (difficult or painful sexual intercourse) in menopausal women. Vaginal estrogen is in a class of medications called hormones. It works by replacing estrogen that is normally produced by the body.
Aletris - More Interactions
Aletris interacts with 77 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
Return to the main supplement interaction checker page
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
Ask A Pharmacist About Your Herbal Questions!
Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
Ask A Pharmacist