Drug & supplement interaction

Alkaline Diet + Phendimetrazine

Phendimetrazine brand names: Plegine, Metra, Weightrol.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Alkaline Diet and Phendimetrazine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Alkaline Diet and Phendimetrazine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Phendimetrazine and Alkaline Diet in our sources. This does not guarantee that the combination is completely free of risk — research on Alkaline Diet alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Alkaline Diet at all — not against Phendimetrazine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Alkaline Diet is an eating pattern rather than something you take. Ask your pharmacist or doctor before changing how you eat while on a prescribed medicine: some medicines are dosed around meals, and a change in diet can change how they work. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Alkaline Diet safety at a glance

Alkaline Diet overall Use caution Generally safe for healthy people, but very restrictive versions may lack key nutrients.
Pregnancy Use caution A balanced version may be fine, but restrictive forms could limit needed nutrients; check with your doctor.
Breastfeeding Use caution Make sure overall nutrition stays adequate; discuss with your healthcare provider.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Phendimetrazine and Alkaline Diet? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Phendimetrazine’s Own FDA Label Lists

This is not an interaction — none of it involves Alkaline Diet. These are the most notable effects listed in the ADVERSE REACTIONS section of Phendimetrazine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you follow Alkaline Diet and take the medicine. 2 of them are worth acting on rather than waiting out — marked below.

  • Pain or burning when passing urine Worth acting on
  • Raised blood pressure Worth acting on
  • Tremor or shakiness
  • Flushing
  • Sweating
  • A fast or pounding heartbeat
  • Anxiety or restlessness
  • Trouble sleeping
  • Constipation
  • Stomach pain

Showing the 10 most notable of 14 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Phendimetrazine. Read the label on DailyMed › Alkaline Diet’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Alkaline Diet side to compare — that is a limit of the record, not a statement that Alkaline Diet has no side effects.

Overlapping uses

What Phendimetrazine Is Prescribed For, and What Alkaline Diet Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Phendimetrazine is a prescription medicine with approved uses on its FDA label. Alkaline Diet is an eating pattern: what follows is what researchers have looked at it for, and how strong that evidence is.

Phendimetrazine is prescribed for: Phendimetrazine tartrate is used to help manage exogenous obesity (excess body weight from outside causes like diet and lifestyle) as a short-term addition to a calorie-restricted diet. It is intended for adults with a BMI of 30 or higher, or a BMI of 27 or higher when other risk factors — such as high blood pressure, diabetes, or high cholesterol — are also present. It is approved for use as monotherapy only, meaning it must not be combined with other weight-loss drugs or stimulants. Both the tablet form and the extended-release capsule form are approved for this purpose.

Read the rest of what Phendimetrazine is prescribed for

This medication is meant to be used for only a few weeks as part of a broader weight-management plan.

Alkaline Diet has been studied for:

  • Obesity studied, not established Alkaline Diet has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Alkaline Diet for obesity

    It is unclear if an alkaline diet is beneficial for the prevention of obesity; the available research is conflicting.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Phendimetrazine on your own; if you are taking Alkaline Diet for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Phendimetrazine

This page covers Alkaline Diet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Phendimetrazine page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Phendimetrazine page

“Of the 17 supplements on file for phendimetrazine, an appetite-suppressant stimulant prescribed short term for weight loss, activated charcoal is the one that demands real caution. Charcoal binds medications in the gut and can sharply cut how much of a drug your body absorbs, leaving you with less appetite control than your prescriptio…”

Reviewed by 2 · Jul 18, 2026

Open the Phendimetrazine interaction page

How much people look this up

Where Alkaline Diet and Phendimetrazine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Alkaline Diet
Steady interest

#1,003 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Phendimetrazine
Top 25%

#334 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Alkaline Diet is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Alkaline Diet reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Alkaline Diet and Phendimetrazine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Eating pattern

About Alkaline Diet

What is Alkaline Diet?

  • General wellness
  • Bone health
  • Weight management
  • Kidney stone prevention
  • Reducing inflammation

The alkaline diet encourages eating more fruits and vegetables while cutting back on meat, dairy, and processed foods, which is generally healthy. However, the idea that food can meaningfully change your blood's pH is not supported by science, since your body tightly controls its own pH. Most benefits people see likely come from simply eating more whole plant foods.

Dietary pattern emphasizing fruits, vegetables, legumes, and limiting meat, dairy, and processed foods

An interaction check asks whether these two react with each other — it does not ask whether Alkaline Diet is a good idea for someone in your situation. Here is what our Alkaline Diet record says about it on its own.

Alkaline Diet: dosing

There is no standard 'dose' for the alkaline diet because it is an eating pattern, not a pill. In general, it means filling more of your plate with fruits, vegetables, and legumes while cutting back on processed foods, added sugar, and excess meat.If you choose to follow it, aim for a balanced version that still includes enough protein, calcium, and other key nutrients. A registered dietitian or your pharmacist can help you adjust the plan safely, especially if you have a health condition or take medications.

From our Alkaline Diet monograph — the full record covers uses, side effects and every documented interaction.

Read the full Alkaline Diet monograph & all interactions
Medication

About Phendimetrazine

What Is Phendimetrazine Used For?

Brand names: Plegine, Metra, Weightrol

Phendimetrazine tartrate is used to help manage exogenous obesity (excess body weight from outside causes like diet and lifestyle) as a short-term addition to a calorie-restricted diet. It is intended for adults with a BMI of 30 or higher, or a BMI of 27 or higher when other risk factors — such as high blood pressure, diabetes, or high cholesterol — are also present.

It is approved for use as monotherapy only, meaning it must not be combined with other weight-loss drugs or stimulants. Both the tablet form and the extended-release capsule form are approved for this purpose. This medication is meant to be used for only a few weeks as part of a broader weight-management plan.

See full Phendimetrazine drug information
Keep checking

Other Drugs & Alkaline Diet

Browse every other medication we’ve checked against Alkaline Diet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Alkaline Diet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Alkaline Diet list.

See the full Alkaline Diet interactions page
See every supplement checked against Phendimetrazine, ranked by severity
Evidence & sources

Alkaline Diet References

The 2 sources that drive our Alkaline Diet monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Alkaline Diet is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Alkaline diets and bone health — NIH Office of Dietary Supplements / MedlinePlus Source
  2. Alkaline Diet: What to Know — Cleveland Clinic Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Following Alkaline Diet While Taking Phendimetrazine: Common Questions

Is it safe to follow Alkaline Diet while taking Phendimetrazine?
We do not list a known interaction between Alkaline Diet and Phendimetrazine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Alkaline Diet and Phendimetrazine used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Alkaline Diet in each. That is a conversation for your prescriber, especially if Phendimetrazine is being adjusted to a target.
Does Phendimetrazine interact with any supplements?
Yes. Phendimetrazine has documented interactions with 17 supplements in our database — Alkaline Diet is not one of them. The Phendimetrazine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Alkaline Diet monograph Uses, safety profile, and every drug interaction in one place Phendimetrazine drug information The full plain-English guide to this medication Phendimetrazine supplement interactions Every supplement checked against Phendimetrazine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Phendimetrazine and Alkaline Diet?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.