Asian Water Plantain - Aspirin, Caffeine, Phenacetin, Propoxyphene Interaction
Herbal: Asian Water Plantain
Also Known As: Alisma plantago-aquatica, Dong Fang Ze Xie, Jilgyeongitaegsa, Llanten de Agua, Plantain, Plantain d'Eau, Rhizoma Alismatis, Ze Xie, Zexie
Drug: Aspirin, Caffeine, Phenacetin, Propoxyphene
Brand names:
Margesic Comp. 65
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Feb 23, 2024
Interaction Details
Aspirin, Caffeine, Phenacetin, Propoxyphene is classified as belonging to the following category: Nephrotoxic Drugs
Studies on animals have shown that Asian water plantain extract, which contains triterpenoids, is generally safe at doses up to 1440 mg/kg orally daily and does not cause harm to the body. However, using a higher dose of the extract, at 33.3 grams/kg orally for 60 days, has been linked to kidney issues, as indicated by increased blood urea nitrogen levels, and enlargement of the liver and kidneys. Additionally, two components of Asian water plantain, alisol A and alisol B, when given in doses of 400 mg/kg daily and 500 mg/kg daily respectively for 6 months, have been found to increase the production of markers that suggest potential kidney damage from certain medications. While these findings suggest there is very little risk that Asian water plantain may interact with drugs that are harmful to the kidneys, caution is still advised if combined with known nephrotoxic drugs (source: pubmed.ncbi.nlm.nih.gov/28408883/)
Interaction Rating
Likelihood of Occurrence
UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Asian Water Plantain Overview
Alisma plantago-aquatica, commonly known as Asian water plantain, is a plant popular in traditional Chinese medicine. The plant contains triterpenoids like alisol-A, alisol-B, and alisol-C, as well as alismol, alismoloxide, orientalols, and chlorogenic acid, among others. Preliminary research suggests potential anti-atherosclerotic and antioxidant effects, as well as renal effects promoting diuresis, but more research is needed to understand its pharmacokinetics and mechanism of action fully.
Asian Water Plantain - More Interactions
Asian Water Plantain interacts with 350 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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