Baikal Skullcap - Methenamine Mandelate Interaction
Herbal: Baikal Skullcap
Also Known As: Scutellaria baicalensis, Baikal Scullcap, Baikal Skullcap Root, Chinese Skullcap, Chinesisches Helmkraut, Escutelaria Asiatica, Huang Qin, Huangquin, Hwanggum, Ogon, Ou-gon, Radix Scutellariae, Scullcap, Scute, Scutellaire, Scutellaire Chinoise, Scutellaria, Skullcap, Sogs
Drug: Methenamine Mandelate
Brand names:
Mandelamine, Methimazole
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 18, 2025
Interaction Details
Methenamine Mandelate is classified as belonging to the following category: Antithyroid Drugs
Theoretically, concomitant use of Baikal skullcap and antithyroid drugs may result in additive activity and increase the risk of hypothyroidism.
In an animal hyperthyroid model, Baikal skullcap improved levels of triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH). The clinical significance of this effect is unclear.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Kim M, Lee BC. Therapeutic effect of Scutellaria baicalensis on L-thyroxine-induced hyperthyroidism rats. Evid Based Complement Alternat Med. 2019;2019:3239649.
Baikal Skullcap Overview
Baikal skullcap (Scutellaria baicalensis) is a perennial herb native to eastern Asia. It is a member of the mint family (Lamiaceae) and is named for its small, helmet-shaped flowers, which resemble medieval helmets.
Baikal skullcap has a long history of use in traditional medicine for a variety of health conditions, including anxiety, insomnia, inflammation, and allergies. Baikal skullcap is also sometimes used to support immune system function and to help protect against certain types of infections.
Most Baikal skullcap dietary supplements are standardized for their baicalein and/or baicalin content.
Methenamine Mandelate Overview
-
Methimazole is used to treat hyperthyroidism, a condition that occurs when the thyroid gland produces too much thyroid hormone. It is also taken before thyroid surgery or radioactive iodine therapy.
-
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Baikal Skullcap - More Interactions
Baikal Skullcap interacts with 932 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
Return to the main supplement interaction checker page
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
Ask A Pharmacist About Your Herbal Questions!
Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
Ask A Pharmacist