Drug & supplement interaction

Black Alder + Medroxyprogesterone

Medroxyprogesterone brand names: Provera, Amen, Depo-Provera, Depo-subQ Provera 104.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Black Alder and Medroxyprogesterone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Black Alder and Medroxyprogesterone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Medroxyprogesterone and Black Alder in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Black Alder safety at a glance

Black Alder overall Use caution Limited safety data exist and it may cause nausea or stomach upset, so use cautiously and briefly.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoiding it is the safer choice.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Medroxyprogesterone and Black Alder? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Medroxyprogesterone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Medroxyprogesterone is filed under 3 classifications — progestin, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Black Alder has documented interactions with 2 drug classes — the most serious being cisplatin (platinol-aq) (moderate) and doxorubicin (adriamycin, others) (moderate) — and none of Medroxyprogesterone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Black Alder Does Interact With Other Medications

Black Alder has 2 moderate known drug interactions in our database — Medroxyprogesterone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 2 No known interaction 2,828 (incl. Medroxyprogesterone)
Taking anything else?

Check Another of Your Medications Against Black Alder

Covers the 2,830 medications we’ve checked against Black Alder. Pick one to open its full report.

What to actually watch for

What Medroxyprogesterone’s Own FDA Label Lists

This is not an interaction — none of it involves Black Alder. These are the most notable effects listed in the ADVERSE REACTIONS section of Medroxyprogesterone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 5 of them are worth acting on rather than waiting out — marked below.

  • Bone thinning Worth acting on
  • Low mood Worth acting on
  • A severe allergic reaction Worth acting on
  • Bleeding or bruising Worth acting on
  • A higher chance of infection Worth acting on
  • Changes to your period
  • A change in sex drive
  • Breast tenderness
  • Acne
  • Weight gain

Showing the 10 most notable of 19 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Medroxyprogesterone. Read the label on DailyMed › Where a percentage is shown, it is the share of 60,501 voluntary FDA FAERS reports for Medroxyprogesterone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Black Alder’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Black Alder side to compare — that is a limit of the record, not a statement that Black Alder has no side effects.

From our Q&A

Questions About Black Alder or Medroxyprogesterone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Black Alder or Medroxyprogesterone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Medroxyprogesterone

This page covers Black Alder only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Medroxyprogesterone page lists 139 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 95 moderate · 41 minor.

From our pharmacist’s overview on the Medroxyprogesterone page

“Medroxyprogesterone (Provera, Depo-Provera) only works if its blood level holds steady, and 121 of the 139 supplements and herbs on file can shift that level through a single liver enzyme, CYP3A4. That makes this a list to respect, with three entries rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Medroxyprogesterone interaction page

One more smart check

Taking Black Alder as Part of a Dietary Supplement Product? Check It for Interactions

We hold 21 real supplement products containing Black Alder, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Black Alder. Even though Black Alder itself has no known interaction with Medroxyprogesterone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Black Alder and Medroxyprogesterone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Black Alder
Top half

#445 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Medroxyprogesterone
Steady interest

#1,952 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Black Alder reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Black Alder and Medroxyprogesterone records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Black Alder

What is Black Alder?

Black Alder
  • Sore throat and mouth inflammation
  • Skin wounds and irritation (topical)
  • Fever and general aches (traditional)
  • Digestive complaints
  • Astringent for minor bleeding

Black Alder is a European tree whose bark and leaves have a long history in folk medicine, mainly as an astringent gargle or wound wash. There is very little modern human research to confirm any of these uses, and it can cause stomach upset, so it should be used cautiously and avoided during pregnancy and breastfeeding.

Alnus glutinosa · Betulaceae · Bark, leaves, and sometimes the catkins · Dried bark or leaf for tea, decoctions, tinctures, and gargles or mouth rinses

An interaction check asks whether these two react with each other — it does not ask whether Black Alder is a good idea for someone in your situation. Here is what our Black Alder record says about it on its own.

Black Alder: dosing

There is no established, standardized dose for Black Alder. Traditional use involved making a tea or decoction from the dried bark or leaves, or using a diluted preparation as a gargle or skin wash.If you choose to use a product, follow the directions on the label and do not exceed the recommended amount.

From our Black Alder monograph — the full record covers uses, side effects and every documented interaction.

Read the full Black Alder monograph & all interactions
Medication

About Medroxyprogesterone

What Is Medroxyprogesterone Used For?

Brand names: Provera, Amen, Depo-Provera, Depo-subQ Provera 104

Medroxyprogesterone is used for different conditions depending on the product form. The injectable forms — including Depo-Provera and intramuscular medroxyprogesterone acetate injectable suspension — are used to prevent pregnancy. Depo-subQ Provera 104 (the subcutaneous injection) is also approved to manage pain associated with endometriosis.

The oral tablets — sold under the brand Provera and as generic medroxyprogesterone acetate tablets — treat secondary amenorrhea (periods that have stopped) and abnormal uterine bleeding caused by hormonal imbalance. The tablets are also used to prevent endometrial hyperplasia (abnormal thickening of the uterine lining) in postmenopausal women with a uterus who are taking daily conjugated estrogens.

Most-Reported Side Effects for Medroxyprogesterone

From FAERS, the FDA’s public side-effect reporting system (60,501 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Meningioma 11,278 reports
Breast cancer 10,971 reports
Breast cancer female 10,184 reports
Breast cancer metastatic 1,943 reports
Nausea 1,449 reports
See full Medroxyprogesterone drug information
Keep checking

Other Drugs & Black Alder

Browse every other medication we’ve checked against Black Alder — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
2Moderate
0Minor
2,827No known interaction
2 Moderate 2,827 No interaction
Moderate

2 interactions

No interaction 2,827 drugs checked — show the list

We also checked Black Alder against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,827 medications checked with no known interaction — see the full Black Alder list.

See the full Black Alder interactions page
See every supplement checked against Medroxyprogesterone, ranked by severity
Evidence & sources

Black Alder References

The 1 references that drive our Black Alder monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Dinic J, Novakovic M, Podolski-Renic A, et al. Antioxidative activity of diarylheptanoids from the bark of black alder (Alnus glutinosa) and their interaction with anticancer drugs. Planta Med 2014;80(13):1088-96. doi: 10.1055/s-0034-1382993. Epub 2014 Au PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Black Alder and Medroxyprogesterone Together: Common Questions

Is it safe to take Black Alder with Medroxyprogesterone?
We do not list a known interaction between Black Alder and Medroxyprogesterone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Black Alder and Medroxyprogesterone combination checked?
Interactions in our licensed database are recorded against drug classes. Medroxyprogesterone is filed under 3 classifications, and Black Alder has documented interactions with 2 drug classes — none of Medroxyprogesterone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Black Alder interact with any other medications?
Yes. Black Alder has 2 documented drug interactions in our database — Medroxyprogesterone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Medroxyprogesterone interact with any supplements?
Yes. Medroxyprogesterone has documented interactions with 139 supplements in our database — Black Alder is not one of them. The Medroxyprogesterone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Black Alder monograph Uses, safety profile, and every drug interaction in one place Medroxyprogesterone drug information The full plain-English guide to this medication Medroxyprogesterone supplement interactions Every supplement checked against Medroxyprogesterone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Medroxyprogesterone and Black Alder?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.