Drug & supplement interaction

Chrysanthemum + Cerliponase Alfa

Cerliponase Alfa brand name: Brineura.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Chrysanthemum and Cerliponase Alfa in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Chrysanthemum and Cerliponase Alfa

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cerliponase Alfa and Chrysanthemum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Chrysanthemum at all — not against Cerliponase Alfa, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chrysanthemum safety at a glance

Chrysanthemum overall Use caution Generally well tolerated as a tea, but it can cause allergic reactions in sensitive people.
Pregnancy Avoid Safety during pregnancy has not been established, so it is best avoided unless your doctor approves.
Breastfeeding Avoid There is not enough reliable information on safety while breastfeeding, so caution or avoidance is wise.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cerliponase Alfa and Chrysanthemum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Chrysanthemum Itself Has Been Linked To

This is not an interaction — nothing below involves Cerliponase Alfa. It is the side-effect record for Chrysanthemum on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Chrysanthemum, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Wheezing / Hives / An allergic reaction Worth acting on Additional detail

    “Topically and via occupational exposure, chrysanthemum can cause allergic reactions. Chrysanthemum allergy symptoms can include urticaria, contact dermatitis, eczema, actinic reticuloid photosensitivity dermatitis, pollinosis, rhinoconjunctivitis, and asthma. There are numerous case reports and studies showing that allergies to Chrysanthemum are very common, with an estimated 60% of Europeans being allergic.”

    Chrysanthemum · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    6 sources cited
    1. 5552. Kuno Y, Kawabe Y, Sakakibara S. Allergic contact dermatitis associated with photosensitivity, from alantolactone in a chrysanthemum farmer. Contact Dermatitis 1999;40:224-5. PubMed
    2. 5554. deJong NW, Vermeulen AM, van Wijik RG, deGroot H. Occupational allergy caused by flowers. Allergy 1998;53:204-9. PubMed
    3. 5556. Camplimi P, Sertoli A, Fabbri P, Panconesi E. Alantolactone sensitivity in chrysanthemum contact dermatitis. Contact Dermatitis 1978;4:93-102. PubMed
    4. 5557. Bleumink E, Mitchell JC, Geismann TA, Towers GH. Contact hypersensitivity to sesquiterpene lactones in Chrysanthemum dermatitis. Contact Dermatitis 1976;2:81-8.
    5. 6958. Lamminpaa A, Estlander T, Jolanki R, Kanerva L. Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 1996;34:330-5. PubMed
    6. 42842. Kuno, Y., Kawabe, Y., and Sakakibara, S. Allergic contact dermatitis associated with photosensitivity, from alantolactone in a chrysanthemum farmer. Contact Dermatitis 1999;40(4):224-225. PubMed
  • Sun sensitivity Additional detail

    Recorded for Chrysanthemum in the same Natural Medicines adverse-effect record shown under Wheezing / Hives / An allergic reaction above.

  • A skin rash Additional detail

    Recorded for Chrysanthemum in the same Natural Medicines adverse-effect record shown under Wheezing / Hives / An allergic reaction above.

Everything above comes from the Natural Medicines adverse-effect record for Chrysanthemum — expand a row for the licensed statement it rests on. We haven’t matched Cerliponase Alfa to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Cerliponase Alfa.

One more smart check

Taking Chrysanthemum as Part of a Dietary Supplement Product? Check It for Interactions

We hold 28 real supplement products containing Chrysanthemum, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chrysanthemum. Even though Chrysanthemum itself has no known interaction with Cerliponase Alfa, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chrysanthemum and Cerliponase Alfa Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chrysanthemum
Steady interest

#765 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cerliponase Alfa
Top half

#777 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chrysanthemum reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Chrysanthemum and Cerliponase Alfa records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chrysanthemum

What is Chrysanthemum?

  • Eye irritation and tired eyes
  • Cooling and 'heat-clearing' in traditional Chinese medicine
  • Cold and flu symptoms
  • Headache
  • Soothing/relaxation
  • High blood pressure (traditional use)

Chrysanthemum flowers are most often used as a soothing tea in traditional Chinese medicine and as a folk remedy for eye irritation, colds, and minor inflammation. Solid human evidence for these uses is limited, so it should be seen as a pleasant traditional drink rather than a proven treatment. People allergic to ragweed and related plants, and those who are pregnant or breastfeeding, should be cautious and talk to a pharmacist or doctor first.

Chrysanthemum morifolium · Asteraceae · Flowers (dried flower heads) · Tea, dried flowers, capsules, extracts, topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Chrysanthemum is a good idea for someone in your situation. Here is what our Chrysanthemum record says about it on its own.

Chrysanthemum: dosing

There is no official standardized dose for chrysanthemum. It is most often used as a tea made from dried flowers, and supplement strength varies widely between products.If you choose to use it, follow the directions on the product label and start with a small amount to see how you react.

From our Chrysanthemum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chrysanthemum monograph & all interactions
Medication

About Cerliponase Alfa

Most-Reported Side Effects for Cerliponase Alfa

From FAERS, the FDA’s public side-effect reporting system (526 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 90 reports
Seizure 75 reports
Vomiting 37 reports
Device related infection 30 reports
Device leakage 28 reports
Keep checking

Other Drugs & Chrysanthemum

Browse every other medication we’ve checked against Chrysanthemum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Chrysanthemum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Chrysanthemum list.

See the full Chrysanthemum interactions page
See every supplement checked against Cerliponase Alfa, ranked by severity
Evidence & sources

Chrysanthemum References

The 25 references that drive our Chrysanthemum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kuno Y, Kawabe Y, Sakakibara S. Allergic contact dermatitis associated with photosensitivity, from alantolactone in a chrysanthemum farmer. Contact Dermatitis 1999;40:224-5. PubMed
  2. deJong NW, Vermeulen AM, van Wijik RG, deGroot H. Occupational allergy caused by flowers. Allergy 1998;53:204-9. PubMed
  3. Camplimi P, Sertoli A, Fabbri P, Panconesi E. Alantolactone sensitivity in chrysanthemum contact dermatitis. Contact Dermatitis 1978;4:93-102. PubMed
  4. Bleumink E, Mitchell JC, Geismann TA, Towers GH. Contact hypersensitivity to sesquiterpene lactones in Chrysanthemum dermatitis. Contact Dermatitis 1976;2:81-8.
  5. Lamminpaa A, Estlander T, Jolanki R, Kanerva L. Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 1996;34:330-5. PubMed
  6. Hausen BM. The sensitizing capacity of Compositae plants. III. Test results and cross-reactions in Compositae-sensitive patients. Dermatologica 1979;159:1-11. DOI
  7. Kuno, Y., Kawabe, Y., and Sakakibara, S. Allergic contact dermatitis associated with photosensitivity, from alantolactone in a chrysanthemum farmer. Contact Dermatitis 1999;40(4):224-225. PubMed
  8. Schulz, K. H., Hausen, B. M., Wallhofer, L., and Schmidt-Loffler, P. Chrysanthemum allergy. Pt. II: Experimental studies on the causative agents. Arch.Dermatol.Forsch. 1975;251(3):235-244.
  9. Singhal, V. and Reddy, B. S. Common contact sensitizers in Delhi. J Dermatol 2000;27(7):440-445. PubMed
  10. Kuroume, T., Todokoro, M., Tomidokoro, H., Kanbe, Y., and Matsumura, T. Chrysanthemum pollinosis in Japan. Int.Arch.Allergy Appl.Immunol. 1975;48(6):800-811.
  11. Groenewoud, G. C., de Jong, N. W., Burdorf, A., de Groot, H., and van Wyk, R. G. Prevalence of occupational allergy to Chrysanthemum pollen in greenhouses in the Netherlands. Allergy 2002;57(9):835-840.
  12. Jovanovic, M. and Poljacki, M. [Compositae dermatitis]. Med Pregl. 2003;56(1-2):43-49. PubMed
  13. Hashimoto, Y., Kawada, A., Aragane, Y., and Tezuka, T. Occupational contact dermatitis from chrysanthemum in a mortician. Contact Dermatitis 2003;49(2):106-107. PubMed
  14. Groenewoud, G. C., de Groot, H., and van Wijk, R. G. Impact of occupational and inhalant allergy on rhinitis-specific quality of life in employees of bell pepper greenhouses in the Netherlands. Ann Allergy Asthma Immunol 2006;96(1):92-97. PubMed
  15. Sharma, S. C. and Kaur, S. Airborne contact dermatitis from Compositae plants in northern India. Contact Dermatitis 1989;21(1):1-5. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chrysanthemum and Cerliponase Alfa Together: Common Questions

Is it safe to take Chrysanthemum with Cerliponase Alfa?
We do not list a known interaction between Chrysanthemum and Cerliponase Alfa. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chrysanthemum monograph Uses, safety profile, and every drug interaction in one place Cerliponase Alfa supplement interactions Every supplement checked against Cerliponase Alfa, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 25 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cerliponase Alfa and Chrysanthemum?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.