Drug & supplement interaction

Cocillana + Entecavir

Entecavir brand name: Baraclude.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Cocillana and Entecavir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Entecavir states a food rule worth keeping to.

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Interaction report

Cocillana and Entecavir

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Entecavir and Cocillana in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Cocillana at all — not against Entecavir, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cocillana safety at a glance

Cocillana overall Use caution It is used in some cough products but lacks strong safety and effectiveness data, and large doses can cause vomiting.
Pregnancy Possibly Unsafe When used orally due to its purported ability to induce menstruation. Read the full pregnancy detail
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid it unless your doctor advises otherwise.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Entecavir and Cocillana? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Entecavir’s Own FDA Label Lists

This is not an interaction — none of it involves Cocillana. These are the most notable effects listed in the ADVERSE REACTIONS section of Entecavir’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on
  • A higher chance of infection Worth acting on
  • Tiredness
  • Dizziness
  • Diarrhea
  • Headache
  • Nausea

From the ADVERSE REACTIONS section of the FDA label for Entecavir. Read the label on DailyMed › Cocillana’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Cocillana side to compare — that is a limit of the record, not a statement that Cocillana has no side effects.

Special populations

Cocillana in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally due to its purported ability to induce menstruation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Entecavir Products Have a Food Rule — Cocillana Should Not Break It

At least one FDA label for a product containing Entecavir says to take it on an empty stomach. Most supplements — Cocillana included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Entecavir on its own and move Cocillana to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Entecavir products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

(2.1) 2.1 Timing of Administration BARACLUDE should be administered on an empty stomach (at least 2 hours after a meal and 2 hours before the next meal).

From the Dosage and Administration section of the FDA label we read for Entecavir — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Entecavir

This page covers Cocillana only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Entecavir page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

Open the Entecavir interaction page

How much people look this up

Where Cocillana and Entecavir Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cocillana
Steady interest

#1,200 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Entecavir
Top half

#1,260 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cocillana reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cocillana and Entecavir records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cocillana

What is Cocillana?

  • Cough relief
  • Chest congestion
  • Loosening mucus (expectorant)
  • Bronchitis symptoms

Cocillana is a tree bark traditionally used as an expectorant in cough and cold remedies, often blended with other ingredients. There is very little modern scientific evidence to confirm how well it works, and it can cause nausea or vomiting in higher amounts, so use it cautiously and check with a pharmacist first.

Guarea rusbyi · Meliaceae · Dried bark · Liquid extract, tincture, syrup (often combined with other cough ingredients), tablets

An interaction check asks whether these two react with each other — it does not ask whether Cocillana is a good idea for someone in your situation. Here is what our Cocillana record says about it on its own.

Cocillana: dosing

There is no well-established standardized dose for cocillana, and it is usually found as one ingredient among several in cough products. Because higher doses can cause vomiting, the amounts used are typically small.If you choose to use a product containing cocillana, follow the directions on the label exactly and do not take more than recommended.

From our Cocillana monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cocillana monograph & all interactions
Medication

About Entecavir

What Is Entecavir Used For?

Brand name: Baraclude

Entecavir treats chronic hepatitis B virus (HBV) infection in adults who have signs of active virus in their blood and liver inflammation or liver damage. It is used when lab tests show persistently elevated liver enzymes (ALT or AST) or when a liver biopsy confirms active disease.

Baraclude (the brand oral solution and tablet) is also approved for children 2 years of age and older weighing at least 10 kg, with the same requirement for evidence of active viral replication and liver involvement. Generic entecavir tablets are indicated for adults; pediatric approval varies by specific product — check with your pharmacist or prescriber.

See full Entecavir drug information
Keep checking

Other Drugs & Cocillana

Browse every other medication we’ve checked against Cocillana — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Cocillana against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Cocillana list.

See the full Cocillana interactions page
See every supplement checked against Entecavir, ranked by severity
Evidence & sources

Cocillana References

The 1 references that drive our Cocillana monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cocillana and Entecavir Together: Common Questions

Is it safe to take Cocillana with Entecavir?
We do not list a known interaction between Cocillana and Entecavir. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Cocillana and Entecavir at the same time of day?
At least one FDA label for a product containing Entecavir says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Entecavir on its own and move Cocillana to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Does Entecavir interact with any supplements?
Yes. Entecavir has documented interactions with 17 supplements in our database — Cocillana is not one of them. The Entecavir interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cocillana monograph Uses, safety profile, and every drug interaction in one place Entecavir drug information The full plain-English guide to this medication Entecavir supplement interactions Every supplement checked against Entecavir, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Entecavir and Cocillana?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.