Cyclamen + Dupilumab
Dupilumab brand name: Dupixent.
We found no known interaction between Cyclamen and Dupilumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Cyclamen and Dupilumab
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Dupilumab and Cyclamen in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Cyclamen at all — not against Dupilumab, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Cyclamen safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Cyclamen in Pregnancy & Breastfeeding
When used orally; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
What Dupilumab Is Prescribed For, and What Cyclamen Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Dupilumab is a prescription medicine with approved uses on its FDA label. Cyclamen is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Dupilumab is prescribed for: Dupixent (dupilumab) injection is approved for several inflammatory conditions. It treats moderate-to-severe atopic dermatitis (eczema) in patients 6 months and older when topical treatments haven't worked well enough. It is also used as an add-on maintenance treatment for moderate-to-severe asthma (ages 6 and up), chronic rhinosinusitis with nasal polyps (ages 12 and up), and COPD with an eosinophilic phenotype in adults. Additionally, Dupixent treats eosinophilic esophagitis (EoE, a chronic inflammatory condition of the esophagus) in patients 1 year and older weighing at least 15 kg, prurigo nodularis (severe itchy skin nodules) in adults, chronic spontaneous urticaria (hives without a clear trigger) in patients 2 and older who haven't responded to antihistamines, bullous pemphigoid (a blistering skin disease) in adults, and allergic fungal rhinosinusitis in patients 6 and older with a history of sinus surgery.
Read the rest of what Dupilumab is prescribed for
It is not for relief of sudden or acute breathing attacks.
Cyclamen has been studied for:
-
Rhinosinusitis studied, not established Cyclamen has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Cyclamen for rhinosinusitis
Preliminary clinical research shows that using a nasal spray containing cyclamen root extract 1.3 mg per spray (Sinuforte Nasal Spray, Hartington Pharmaceutical), given as one spray in each nostril daily for 15 days, reduces facial pain, mucosal edema, and sinus opacification on CT scan when compared with placebo in adults with acute rhinosinusitis.
2 sources cited
- 98456. Pfaar O, Mullol J, Anders C, Hörmann K, Klimek L. Cyclamen europaeum nasal spray, a novel phytotherapeutic product for the management of acute rhinosinusitis: a randomized double-blind, placebo-controlled trial. Rhinology 2012;50(1):37-44. doi: 10.4193/Rh DOI
- 98457. Ponikau JU, Hamilos DL, Barreto A, et al. An exploratory trial of Cyclamen europaeum extract for acute rhinosinusitis. Laryngoscope 2012;122(9):1887-92. doi: 10.1002/lary.23366.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Dupilumab on your own; if you are taking Cyclamen for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
Where Cyclamen and Dupilumab Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#779 of 1,452 supplements looked up here in the last 7 days
#1,641 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cyclamen reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Cyclamen and Dupilumab records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Cyclamen
What is Cyclamen?
- Sinus congestion (sinusitis)
- Headache and migraine (traditional/homeopathic)
- Menstrual complaints (traditional use)
- Digestive complaints (traditional use)
Cyclamen is an ornamental plant whose tuber contains potentially toxic compounds called saponins. It has been studied mostly as a nasal preparation for sinus congestion, but evidence is limited and the raw plant can be poisonous, so it should not be used without professional guidance.
Cyclamen europaeum · Primulaceae · Tuber (root); sometimes leaves and flowers · Homeopathic preparations, nasal sprays/extracts (in some regions), and rarely tinctures
An interaction check asks whether these two react with each other — it does not ask whether Cyclamen is a good idea for someone in your situation. Here is what our Cyclamen record says about it on its own.
Cyclamen: dosing
There is no well-established, standardized dose of cyclamen for general use. Because the plant is toxic, dosing should never be guessed or self-made.If you use a commercial product, such as a nasal preparation or homeopathic remedy, follow the directions on the label exactly and do not exceed the recommended amount.
From our Cyclamen monograph — the full record covers uses, side effects and every documented interaction.
About Dupilumab Injection
What Is Dupilumab Injection Used For?
Brand name: Dupixent
Dupixent (dupilumab) injection is approved for several inflammatory conditions. It treats moderate-to-severe atopic dermatitis (eczema) in patients 6 months and older when topical treatments haven't worked well enough. It is also used as an add-on maintenance treatment for moderate-to-severe asthma (ages 6 and up), chronic rhinosinusitis with nasal polyps (ages 12 and up), and COPD with an eosinophilic phenotype in adults.
Additionally, Dupixent treats eosinophilic esophagitis (EoE, a chronic inflammatory condition of the esophagus) in patients 1 year and older weighing at least 15 kg, prurigo nodularis (severe itchy skin nodules) in adults, chronic spontaneous urticaria (hives without a clear trigger) in patients 2 and older who haven't responded to antihistamines, bullous pemphigoid (a blistering skin disease) in adults, and allergic fungal rhinosinusitis in patients 6 and older with a history of sinus surgery. It is not for relief of sudden or acute breathing attacks.
Most-Reported Side Effects for Dupilumab
From FAERS, the FDA’s public side-effect reporting system (478,975 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Cyclamen
Browse every other medication we’ve checked against Cyclamen — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Cyclamen against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Ivermectin ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Abemaciclib ›
- Docusate ›
- Hydroxyurea ›
- Valacyclovir ›
- Ibuprofen ›
- Methamphetamine ›
- Semaglutide ›
- Sumatriptan ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Acyclovir ›
- Amitriptyline ›
- Methotrexate ›
- Doxycycline ›
- Fluoxetine ›
- Lamotrigine ›
- Amphetamine ›
- Acetaminophen, Codeine ›
- Pregabalin ›
- Gabapentin ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Methylene Blue ›
- Clonazepam ›
- Omeprazole ›
- Amlodipine Besylate ›
- Quetiapine ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Naproxen ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Cyclamen list.
Cyclamen References
The 4 references that drive our Cyclamen monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Jaspersen-Schib R, Theus L, Guirguis-Oeschger M, et al. [Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center]. Schweiz Med Wochenschr 1996;126:1085-98.
- Pfaar O, Mullol J, Anders C, Hörmann K, Klimek L. Cyclamen europaeum nasal spray, a novel phytotherapeutic product for the management of acute rhinosinusitis: a randomized double-blind, placebo-controlled trial. Rhinology 2012;50(1):37-44. doi: 10.4193/Rh DOI
- Ponikau JU, Hamilos DL, Barreto A, et al. An exploratory trial of Cyclamen europaeum extract for acute rhinosinusitis. Laryngoscope 2012;122(9):1887-92. doi: 10.1002/lary.23366.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Cyclamen and Dupilumab Together: Common Questions
Is it safe to take Cyclamen with Dupilumab?
Do Cyclamen and Dupilumab have any of the same side effects?
Are Cyclamen and Dupilumab used for the same thing?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.