Dong Quai - Voltaren (Diclofenac Sodium) Interaction
Herbal: Dong Quai
Also Known As: Angelica sinensis, Angelica China, Chinese Angelica, Dang Gui, Danggui, Danguia, Dang Gui Shen, Dang Gui Tou, Dang Gui Wei, Don Quai, Female Ginseng, Kinesisk Kvan, Ligustilides, Phytoestrogen, Tan Kue Bai Zhi, Tang Kuei, Tanggwi, Toki
Drug: Diclofenac Sodium
Brand names:
Voltaren XR, Voltaren, Voltaren SR, Diclo, Difenac, Diclo SR, Voltarol, Acoflam, Defenac, Dicloflex, Diclovol, Diclozip, Fenactol, Flamrase, Volraman, Diclomax SR, Diclomax Retard, Motifene 75 mg, Voltarol 75 mg SR, Acoflam 75 SR, Defenac SR, Dexomon 75 SR, Dicloflex 75 SR, Diclovol SR, Fenactol 75 mg SR, Flamatak 75 MR, Flamrase SR, Flexotard MR 75, Rheumatac Retard 75, Rhumalgan CR, Slofenac SR, Volsaid Retard 75, Voltarol Retard, Acoflam Retard, Defenac Retard, Dexomon Retard 100, Dicloflex Retard, Diclovol Retard, Fenactol Retard 100 mg, Flamatak 100 MR, Volsaid Retard 100, Voltarol Ophtha Multidose, Voltarol Ophtha, Pennsaid, Voltaren Emulgel, Dyloject
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 11, 2025
Interaction Details
Diclofenac Sodium is classified as belonging to the following category: Anticoagulant/Antiplatelet Drugs
Theoretically, dong quai may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Animal studies suggest that dong quai has antithrombin activity and inhibits platelet aggregation due to its coumarin components. Additionally, some case reports in humans suggest that dong quai can increase the anticoagulant effects of warfarin. However, clinical research in healthy adults shows that taking 1 gram of dong quai root daily for 3 weeks does not significantly inhibit platelet aggregation or cause bleeding. Until more is known, use dong quai with caution in patients taking antiplatelet/anticoagulant drugs.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Page RL II, Lawrence JD. Potentiation of warfarin by dong quai. Pharmacotherapy 1999;19:870-6.
- Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7.
- Hoult JR, Paya M. Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential. Gen Pharmacol 1996;27:713-22..
- Ellis GR, Stephens MR. Untitled (photograph and a brief case report). BMJ 1999;319:650.
- Scott, G. N. and Elmer, G. W. Update on natural product--drug interactions. Am J Health Syst.Pharm 2-15-2002;59(4):339-347.
- Fung FY, Wong WH, Ang SK, et al. A randomized, double-blind, placebo- controlled study on the anti-haemostatic effects of Curcuma longa, Angelica sinensis and Panax ginseng. Phytomedicine. 2017;32:88-96.
Dong Quai Overview
Dong quai (Angelica sinensis) is a plant native to Asia and has been used in traditional medicine for centuries. It is often referred to as "female ginseng" and is used to treat a variety of health conditions, particularly those related to the female reproductive system. It is also claimed to have anti-inflammatory and antioxidant properties as well as an ability to improve blood circulation. When utilized for dietary supplements, the root of Dong quai is used.
Diclofenac Sodium Overview
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Diclofenac capsules (Zipsor, Zorvolex) and tablets (Cataflam) are used to relieve mild to moderate pain. Diclofenac extended-release tablets (Voltaren XR), tablets (Cataflam), and delayed-release tablets (available generically) are used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). Diclofenac extended-release tablets and delayed-release tablets are also used to treat ankylosing spondylitis (arthritis that mainly affects the spine). Diclofenac tablets (Cataflam) are also used to treat painful menstrual periods. Diclofenac solution (Cambia) is used to treat migraine headaches in adults, but cannot be used to prevent migraines or to treat other types of headaches. Diclofenac is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.
Dong Quai - More Interactions
Dong Quai interacts with 162 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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