Eucalyptus - Seroquel (Quetiapine) Interaction
Herbal: Eucalyptus
Also Known As: Eucalyptus globulus, Blue Gum, Blue Mallee, Blue Mallee Oil, Eucalipto, Eucalypti Folium, Eucalyptol, Eucalyptol Oil, Eucalyptus Essential Oil, Eucalyptus Oil, Fever Tree, Fieberbaumblatter, Gully Gum, Gum Tree, Huile Essentielle d'Eucalyptus, Huile d'Eucalyptol
Drug: Quetiapine
Brand names:
Seroquel, Dopaquel
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 08, 2025
Interaction Details
Quetiapine is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP3A4, although this has not been reported in humans.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1
Eucalyptus Overview
Eucalyptus is a plant that is native to Australia and a member of the Myrtaceae family. It is known for its distinctive, aromatic leaves, small flowers, and as the primary food of koala bears.
Eucalyptus has a long history of use in traditional medicine, particularly in Aboriginal and Western herbal medicine. It is believed to have anti-inflammatory and pain-relieving effects and is used to treat a variety of conditions, including digestive problems, respiratory infections, and skin disorders.
Eucalyptus is also commonly used as a natural treatment for colds and flu due to its expectorant properties, which help to loosen and remove mucus from the respiratory tract. It is often a component of dietary supplements marketed toward improving breathing or respiration. It is also very commonly utilized in topical aromatherapy medicines, such as Vick's Vaporub (which contains eucalyptus oil).
Quetiapine Overview
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Quetiapine tablets and extended-release (long-acting) tablets are used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Quetiapine tablets and extended-release tablets are also used alone or with other medications to treat episodes of mania (frenzied, abnormally excited or irritated mood) or depression in patients with bipolar disorder (manic depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods). In addition, quetiapine tablets and extended-release tablets are used with other medications to prevent episodes of mania or depression in patients with bipolar disorder. Quetiapine extended-release tablets are also used along with other medications to treat depression. Quetiapine tablets may be used as part of a treatment program to treat bipolar disorder and schizophrenia in children and teenagers. Quetiapine is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substances in the brain.
Eucalyptus - More Interactions
Eucalyptus interacts with 853 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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