Gossypol - Ephedrine, Guaifenesin, Phenobarbital, Theophylline Interaction
Herbal: Gossypol
Also Known As: Coton Velu, Cotonnier Herbacé, Cottonseed Oil Extract, Extrait d'Huile de Coton, Gosipol, Karpasa
Drug: Ephedrine, Guaifenesin, Phenobarbital, Theophylline
Brand names:
Mudrane GG
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 18, 2025
Interaction Details
Ephedrine, Guaifenesin, Phenobarbital, Theophylline is classified as belonging to the following category: Theophylline
Theoretically, gossypol's male contraceptive effects might be reduced when taken with theophylline.
In vitro research shows that theophylline interferes with the ability of gossypol to decrease sperm motility.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Cowart CL, London SN, Vernon MW, Pedigo NG. The effects of cyclic adenosine monophosphate, forskolin, and theophylline on motility parameters in gossypol-treated human sperm. Fertil Steril 1994;61:929-34.
Gossypol Overview
Gossypol is a natural compound found in cotton plants (Gossypium species) and other related plants. It's known for its potential use as a male contraceptive due to its ability to inhibit sperm production. However, gossypol also poses health risks in high doses, including potential toxicity to the heart and other organs, which has limited its widespread medical application.
Gossypol - More Interactions
Gossypol interacts with 104 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
Return to the main supplement interaction checker page
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
Ask A Pharmacist About Your Herbal Questions!
Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
Ask A Pharmacist