Drug & supplement interaction

Homotaurine + nitisinone

nitisinone brand names: Orfadin, Nityr.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Homotaurine and nitisinone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Homotaurine and nitisinone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between nitisinone and Homotaurine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Homotaurine at all — not against nitisinone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Homotaurine safety at a glance

Homotaurine overall Use caution Generally tolerated in studies, but long-term safety as a supplement is not well established.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid There is not enough safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining nitisinone and Homotaurine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Homotaurine and nitisinone May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea Additional detail

    Homotaurine

    “Orally, homotaurine seems to be generally well tolerated. The most frequent side effects reported in clinical trials are nausea, vomiting, diarrhea, dizziness, headache, and sleep disorders.”

    Homotaurine · Natural Medicines adverse-effect record, reported in cluster headache.

    6 sources cited
    1. 17063. Greenberg SM, Rosand J, Schneider AT, et al. A phase 2 study of tramiprosate for cerebral amyloid angiopathy. Alzheimer Dis Assoc Disord 2006;20:269-74. PubMed
    2. 17064. Aisen PS, Saumier D, Briand R, et al. A Phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease. Neurology 2006;67:1757-63.
    3. 17065. Wright TM. Tramiprosate. Drugs Today (Barc) 2006;42:291-8.
    4. 101097. Abushakra S, Porsteinsson A, Scheltens P, et al. Clinical effects of tramiprosate in APOE4/4 homozygous patients with mild Alzheimer's disease suggest disease modification potential. J Prev Alzheimers Dis. 2017;4(3):149-156. PubMed
    5. 101099. Ricciardi L, De Nigris F, Specchia A, Fasano A. Homotaurine in Parkinson's disease. Neurol Sci. 2015;36(9):1581-7. PubMed
    6. 104786. Marino PF, Rossi GCM, Campagna G, et al. Effects of citicoline, homotaurine, and vitamin E on contrast sensitivity and visual-related quality of life in patients with primary open-angle glaucoma: A preliminary study. Molecules. 2020 Nov 29;25(23):5614. PubMed

    “Orally, some of the most frequent side effects of homotaurine are nausea, vomiting, and diarrhea. Nausea and vomiting are dose-dependent and the incidence ranges from 5% to 30% with doses of 50-150 mg twice daily. However, in some large studies, nausea and vomiting occurred at a similar rate in the placebo group.”

    Homotaurine · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 17063. Greenberg SM, Rosand J, Schneider AT, et al. A phase 2 study of tramiprosate for cerebral amyloid angiopathy. Alzheimer Dis Assoc Disord 2006;20:269-74. PubMed
    2. 17064. Aisen PS, Saumier D, Briand R, et al. A Phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease. Neurology 2006;67:1757-63.
    3. 17065. Wright TM. Tramiprosate. Drugs Today (Barc) 2006;42:291-8.
    4. 101097. Abushakra S, Porsteinsson A, Scheltens P, et al. Clinical effects of tramiprosate in APOE4/4 homozygous patients with mild Alzheimer's disease suggest disease modification potential. J Prev Alzheimers Dis. 2017;4(3):149-156. PubMed
    5. 101099. Ricciardi L, De Nigris F, Specchia A, Fasano A. Homotaurine in Parkinson's disease. Neurol Sci. 2015;36(9):1581-7. PubMed
    6. 104786. Marino PF, Rossi GCM, Campagna G, et al. Effects of citicoline, homotaurine, and vitamin E on contrast sensitivity and visual-related quality of life in patients with primary open-angle glaucoma: A preliminary study. Molecules. 2020 Nov 29;25(23):5614. PubMed

    nitisinone

    Listed in the ADVERSE REACTIONS section of the FDA label for nitisinone. Read the label on DailyMed ›

Reported for Homotaurine but not commonly for nitisinone: dizziness, vomiting, headache and nausea.

Effects for nitisinone come from the ADVERSE REACTIONS section of its FDA label; effects for Homotaurine come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 948 voluntary FDA FAERS reports for nitisinone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With nitisinone

This page covers Homotaurine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the nitisinone page lists 21 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Cannabinol (cbn) (moderate), Cannabis (moderate), Coffee Charcoal (moderate) and Delta-9-tetrahydrocannabinol (thc) (moderate).

By severity: 1 major · 11 moderate · 9 minor.

From our pharmacist’s overview on the nitisinone page

“For a child or adult with hereditary tyrosinemia type 1, nitisinone (Orfadin, Nityr) is the medication holding a dangerous metabolic disease in check, which is why the 21 supplements on this page warrant genuine care rather than a shrug. Activated charcoal is the single major-rated entry and the one to understand first, since it can so…”

Reviewed by 2 · Jul 18, 2026

Open the nitisinone interaction page

One more smart check

Taking Homotaurine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Homotaurine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Homotaurine. Even though Homotaurine itself has no known interaction with nitisinone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Homotaurine and nitisinone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Homotaurine
Steady interest

#1,294 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication nitisinone
Top 25%

#689 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Homotaurine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Homotaurine and nitisinone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Homotaurine

What is Homotaurine?

  • Memory support
  • Brain and cognitive health
  • Alzheimer's disease (investigational)
  • General neuroprotection

Homotaurine (also called tramiprosate) is a small amino acid-like molecule studied mainly for slowing memory loss and Alzheimer's disease. Large clinical trials did not clearly prove it works, and it is now sold as a dietary supplement rather than an approved drug. Talk to your pharmacist or doctor before using it, especially if you have a medical condition.

Synthesized compound (also found naturally in some seaweeds) · Capsules, tablets

An interaction check asks whether these two react with each other — it does not ask whether Homotaurine is a good idea for someone in your situation. Here is what our Homotaurine record says about it on its own.

Homotaurine: dosing

There is no officially established supplement dose for homotaurine. Doses used in research were chosen for studying Alzheimer's disease and may not match what is sold in stores.If you choose to use a homotaurine product, follow the directions on the label and do not exceed the recommended amount.

From our Homotaurine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Homotaurine monograph & all interactions
Medication

About Nitisinone

What Is Nitisinone Used For?

Brand names: Orfadin, Nityr

Nitisinone (as Orfadin capsules, Orfadin oral suspension, Nityr tablets, and generic Nitisinone capsules) is used to treat hereditary tyrosinemia type 1 (HT-1) — a rare inherited disease in which the body cannot properly break down the amino acid tyrosine, leading to toxic buildup that damages the liver and kidneys. It is used in both adults and children, always together with a strict low-tyrosine, low-phenylalanine diet.

Harliku tablets are approved for a different rare inherited condition: alkaptonuria (AKU). In adults with AKU, Harliku reduces the level of homogentisic acid (HGA) — a harmful substance that builds up in the urine and body tissues. Harliku is not approved for HT-1, and the other nitisinone products are not approved for AKU.

Most-Reported Side Effects for nitisinone

From FAERS, the FDA’s public side-effect reporting system (948 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Amino acid level increased 133 reports
Liver transplant 118 reports
Hepatocellular carcinoma 61 reports
Alpha 1 foetoprotein increased 52 reports
Treatment noncompliance 51 reports
See full Nitisinone drug information
Keep checking

Other Drugs & Homotaurine

Browse every other medication we’ve checked against Homotaurine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Homotaurine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Homotaurine list.

See the full Homotaurine interactions page
See every supplement checked against nitisinone, ranked by severity
Evidence & sources

Homotaurine References

The 15 references that drive our Homotaurine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Aisen PS, Gauthier S, Vellas B, et al. Alzhemed: a potential treatment for Alzheimer's disease. Curr Alzheimer Res 2007;4:473-8.
  2. Greenberg SM, Rosand J, Schneider AT, et al. A phase 2 study of tramiprosate for cerebral amyloid angiopathy. Alzheimer Dis Assoc Disord 2006;20:269-74. PubMed
  3. Aisen PS, Saumier D, Briand R, et al. A Phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease. Neurology 2006;67:1757-63.
  4. Wright TM. Tramiprosate. Drugs Today (Barc) 2006;42:291-8.
  5. Wong GT. FDA deems US Alzhemed trial results inconclusive. Alzheimer Research Forum. August 28, 2007. Available at: www.alzforum.org/new/detail.asp?id=1647. (Accessed 26 May 2009).
  6. McCaffrey P, Strobel G. Philadelphia: European trial of Alzhemed ends, marketing morphs to supplement. Alzheimer Research Forum. November 19, 2007. Available at: www.alzforum.org/new/detail.asp?id=1691. (Accessed 26 May 2009).
  7. Bossú P, Salani F, Ciaramella A, et al. Anti-inflammatory effects of homotaurine in patients with amnestic mild cognitive impairment. Front Aging Neurosci. 2018;10:285. PubMed
  8. Abushakra S, Porsteinsson A, Scheltens P, et al. Clinical effects of tramiprosate in APOE4/4 homozygous patients with mild Alzheimer's disease suggest disease modification potential. J Prev Alzheimers Dis. 2017;4(3):149-156. PubMed
  9. Spalletta G, Cravello L, Gianni W, et al. Homotaurine effects on hippocampal volume loss and episodic memory in amnestic mild cognitive impairment. J Alzheimers Dis. 2016;50(3):807-16. PubMed
  10. Ricciardi L, De Nigris F, Specchia A, Fasano A. Homotaurine in Parkinson's disease. Neurol Sci. 2015;36(9):1581-7. PubMed
  11. Gauthier S, Aisen PS, Ferris SH, et al. Effect of tramiprosate in patients with mild-to-moderate Alzheimer's disease: exploratory analyses of the MRI sub-group of the Alphase study. J Nutr Health Aging. 2009;13(6):550-7. PubMed
  12. Aisen PS, Gauthier S, Ferris SH, et al. Tramiprosate in mild-to-moderate Alzheimer's disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study). Arch Med Sci. 2011;7(1):102-11. PubMed
  13. Marino PF, Rossi GCM, Campagna G, et al. Effects of citicoline, homotaurine, and vitamin E on contrast sensitivity and visual-related quality of life in patients with primary open-angle glaucoma: A preliminary study. Molecules. 2020 Nov 29;25(23):5614. PubMed
  14. Toppi E, Sireno L, Lembo M, et al. IL-33 and IL-10 Serum Levels Increase in MCI Patients Following Homotaurine Treatment. Front Immunol 2022;13:813951. PubMed
  15. Rossi GCM, Rolle T, De Silvestri A, et al. Multicenter, Prospective, Randomized, Single Blind, Cross-Over Study on the Effect of a Fixed Combination of Citicoline 500 mg Plus Homotaurine 50 mg on Pattern Electroretinogram (PERG) in Patients With Open Angl

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Homotaurine and nitisinone Together: Common Questions

Is it safe to take Homotaurine with nitisinone?
We do not list a known interaction between Homotaurine and nitisinone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Homotaurine and nitisinone have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does nitisinone interact with any supplements?
Yes. nitisinone has documented interactions with 21 supplements in our database — Homotaurine is not one of them. The nitisinone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Homotaurine monograph Uses, safety profile, and every drug interaction in one place Nitisinone drug information The full plain-English guide to this medication nitisinone supplement interactions Every supplement checked against nitisinone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 15 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About nitisinone and Homotaurine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.