Honey - Pimozide Interaction
Herbal: Honey
Also Known As: Beri honey, Blossom Honey, Buckwheat Honey, Chestnut Honey, Clarified Honey, Honeydew Honey, Honig, Jellybush Honey, Madhu, Manuka Honey, Medihoney, Mel, Miel, Purified Honey, Strained Honey, Tualang Honey
Drug: Pimozide
Brand names:
Orap
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 18, 2025
Interaction Details
Pimozide is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Some clinical research shows that honey induces CYP3A4. However, other clinical studies found no effect on CYP3A4 activity. Different honey preparations may have different effects on CYP3A4.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Tushar, T., Vinod, T., Rajan, S., Shashindran, C., and Adithan, C. Effect of honey on CYP3A4, CYP2D6 and CYP2C19 enzyme activity in healthy human volunteers. Basic Clin Pharmacol Toxicol 2007;100(4):269-272.
- Fetzner, L., Burhenne, J., Weiss, J., Völker, M., Unger, M., Mikus, G., and Haefeli, W. E. Daily honey consumption does not change CYP3A activity in humans. J Clin Pharmacol 2011;51(8):1223-1232.
Honey Overview
Honey is a sweet, viscous substance produced by bees from the nectar of flowers and is composed of a mixture of sugars, water, various enzymes, and minerals.
It has been used for centuries as a natural remedy for a variety of health conditions for its purported antibacterial, immune-boosting, and anti-inflammatory effects. Honey is used both orally and topically. Orally, it has been used for conditions such as bronchitis and topically for wound healing and burns.
It is important to note that there are many different types of honey and its composition can vary depending on the type of flowers the bees visit and the processing methods used. Manuka honey, for example, is a type of honey that is produced from the nectar of the manuka bush and is believed to have higher levels of certain compounds with medicinal properties.
Pimozide Overview
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Pimozide is used to control motor or verbal tics (an uncontrollable need to repeat certain movements or sounds) caused by Tourette's disorder (condition characterized by motor or verbal tics). Pimozide should only be used to treat people who cannot take other medications or who have taken other medications without good results. Pimozide should only be used to treat severe tics that stop the person from learning, working, or performing daily activities.
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Pimozide is in a class of medications called conventional antipsychotics. It works by decreasing abnormal excitement in the brain.
Honey - More Interactions
Honey interacts with 714 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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