Drug & supplement interaction

Japanese Mint + Fruquintinib

Fruquintinib brand name: Fruzaqla.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Japanese Mint and Fruquintinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Japanese Mint and Fruquintinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fruquintinib and Japanese Mint in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Japanese Mint at all — not against Fruquintinib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Japanese Mint safety at a glance

Japanese Mint overall Use caution Generally fine in small culinary or diluted amounts, but the concentrated essential oil can be irritating or toxic if misused.
Pregnancy Use caution Food amounts are likely fine, but avoid concentrated oil or supplements unless cleared by your doctor.
Breastfeeding Use caution Limited safety data; avoid concentrated oil and keep it off the chest area while nursing.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fruquintinib and Japanese Mint? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Japanese Mint Itself Has Been Linked To

This is not an interaction — nothing below involves Fruquintinib. It is the side-effect record for Japanese Mint on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Japanese Mint, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Wheezing Worth acting on Additional detail

    “Topically, use of Japanese mint oil on the face in children can trigger glottal or bronchial spasm, asthma-like attacks, or respiratory failure (18). When inhaled, the vapor from Japanese mint oil can cause flushing, headache, or worsening bronchial asthma spasms (11,18).”

    Japanese Mint · Natural Medicines adverse-effect record, reported in asthma.

    2 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  • Flushing / Headache Additional detail

    Recorded for Japanese Mint in the same Natural Medicines adverse-effect record shown under Wheezing above.

  • A skin rash Additional detail

    “Topically, Japanese mint may cause contact dermatitis (11,18).”

    Japanese Mint · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Japanese Mint — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Fruquintinib’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Fruquintinib column appears here.

Overlapping uses

What Fruquintinib Is Prescribed For, and What Japanese Mint Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Fruquintinib is a prescription medicine with approved uses on its FDA label. Japanese Mint is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Fruquintinib is prescribed for: Fruzaqla (fruquintinib) is used to treat adults with metastatic colorectal cancer (mCRC) — colorectal cancer that has spread to other parts of the body. It is specifically for patients who have already been treated with several standard chemotherapy regimens and other targeted therapies. Fruzaqla is intended for patients who have previously received fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy, and — if their tumor is RAS wild-type and it is medically appropriate — an anti-EGFR therapy.

Japanese Mint has been studied for:

  • Cancer studied, not established Japanese Mint has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Japanese Mint for cancer

    Although there has been interest in using oral Japanese mint for cancer, there is insufficient reliable information about the clinical effects of Japanese mint for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Fruquintinib on your own; if you are taking Japanese Mint for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Fruquintinib

This page covers Japanese Mint only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fruquintinib page lists 168 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 124 moderate · 38 minor.

From our pharmacist’s overview on the Fruquintinib page

“Fruquintinib (Fruzaqla) is an oral targeted therapy for advanced colorectal cancer, which means keeping its blood level steady is part of what makes it work, and I would treat this supplement list with genuine care. Of the 168 ingredients on file, the large majority interact through CYP3A4, the liver enzyme that clears the drug, so the…”

Reviewed by 2 · Jul 18, 2026

Open the Fruquintinib interaction page

One more smart check

Taking Japanese Mint as Part of a Dietary Supplement Product? Check It for Interactions

We hold 157 real supplement products containing Japanese Mint, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Japanese Mint. Even though Japanese Mint itself has no known interaction with Fruquintinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Japanese Mint and Fruquintinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Japanese Mint
Steady interest

#846 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fruquintinib
Top half

#886 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Japanese Mint reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Japanese Mint and Fruquintinib records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Japanese Mint

What is Japanese Mint?

  • Digestive upset
  • Headache relief (topical)
  • Cold and congestion
  • Muscle and joint aches
  • Itchy skin and minor pain

Japanese mint is a menthol-rich plant used mainly for its essential oil in topical rubs, inhalants, and digestive remedies. There is some support for menthol's soothing and cooling effects, but high-quality studies on Japanese mint itself are limited, and the concentrated oil can be irritating or harmful if misused. Talk to your pharmacist or doctor before using it, especially in children or if pregnant.

Mentha arvensis · Lamiaceae · Leaves and essential oil · Essential oil, topical balms and rubs, tea, capsules, inhalants, lozenges

An interaction check asks whether these two react with each other — it does not ask whether Japanese Mint is a good idea for someone in your situation. Here is what our Japanese Mint record says about it on its own.

Japanese Mint: dosing

There is no official standardized dose for Japanese mint. The right amount depends heavily on the form — tea, capsule, balm, or essential oil — and on the menthol concentration.The safest approach is to follow the directions on the specific product label and not exceed them. Essential oils should be diluted as directed and are not meant to be swallowed unless a product is specifically made for that use.

From our Japanese Mint monograph — the full record covers uses, side effects and every documented interaction.

Read the full Japanese Mint monograph & all interactions
Medication

About Fruquintinib

What Is Fruquintinib Used For?

Brand name: Fruzaqla

Fruzaqla (fruquintinib) is used to treat adults with metastatic colorectal cancer (mCRC) — colorectal cancer that has spread to other parts of the body. It is specifically for patients who have already been treated with several standard chemotherapy regimens and other targeted therapies.

Fruzaqla is intended for patients who have previously received fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy, and — if their tumor is RAS wild-type and it is medically appropriate — an anti-EGFR therapy.

Most-Reported Side Effects for Fruquintinib

From FAERS, the FDA’s public side-effect reporting system (3,770 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 470 reports
Colorectal cancer metastatic 388 reports
Colon cancer 371 reports
Diarrhea 275 reports
Blood pressure increased 269 reports
See full Fruquintinib drug information
Keep checking

Other Drugs & Japanese Mint

Browse every other medication we’ve checked against Japanese Mint — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Japanese Mint against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Japanese Mint list.

See the full Japanese Mint interactions page
See every supplement checked against Fruquintinib, ranked by severity
Evidence & sources

Japanese Mint References

The 2 references that drive our Japanese Mint monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Japanese Mint and Fruquintinib Together: Common Questions

Is it safe to take Japanese Mint with Fruquintinib?
We do not list a known interaction between Japanese Mint and Fruquintinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Japanese Mint and Fruquintinib used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Japanese Mint in each. That is a conversation for your prescriber, especially if Fruquintinib is being adjusted to a target.
Does Fruquintinib interact with any supplements?
Yes. Fruquintinib has documented interactions with 168 supplements in our database — Japanese Mint is not one of them. The Fruquintinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Japanese Mint monograph Uses, safety profile, and every drug interaction in one place Fruquintinib drug information The full plain-English guide to this medication Fruquintinib supplement interactions Every supplement checked against Fruquintinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Fruquintinib and Japanese Mint?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.