Jequirity - Symproic (Naldemedine Tosylate) Interaction
Herbal: Jequirity
Also Known As: Abrus precatorius, Bead Vine, Black-Eyed Susan, Chanothi, Chashami -Khurosa, Chunhali, Crab's Eye, Ghunchi, Gunchi, Gundumani, Gunja, Guruginia, Gurugunii, Indian Bead, Jequirity Seed, Kunch, Kundumani, Pater Noster, Pois Rouge, Prayer Beads, Prayer Head, Precatory Bean
Drug: Naldemedine Tosylate
Brand names:
Symproic
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 18, 2025
Interaction Details
Naldemedine Tosylate is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates
In vitro research shows that jequirity extract inhibits CYP3A4 enzymes. Theoretically, taking jequirity may inhibit the metabolism of CYP3A4 substrates.
Interaction Rating
Likelihood of Occurrence
UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
References
- Ai C, Miao X, Wang L, He J. Discovery and Activity Evaluation of the Inhibitory Effect of Four Kinds Traditional Chinese Medicine Extracts on the CYP3A4 Enzyme. Comb Chem High Throughput Screen 2022.
Jequirity Overview
Jequirity is a plant in the Fabaceae family, and native to India and tropical regions of the world. The plant is known for its bright red seeds, which have a black band at the base.
While jequirity has been used in traditional medicine for a number of conditions, including asthma, fever, sore throat, bronchitis, hepatitis, constipation, and infectious disease, the seeds are toxic and can be harmful if ingested. They contain a protein known as abrin, and when ingested, can cause severe gastrointestinal symptoms, including diarrhea which can become bloody.
Due to safety concerns, the use of jequirity as a medicine is not recommended.
Naldemedine Tosylate Overview
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Naldemedine is used to treat constipation caused by opioid (narcotic) pain medications in adults with chronic (ongoing) pain that is not caused by cancer. Naldemedine is in a class of medications called peripherally acting mu-opioid receptor antagonists. It works by protecting the bowel from the effects of opioid (narcotic) medications.
Jequirity - More Interactions
Jequirity interacts with 787 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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