Mullein - Bufferin (Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide) Interaction

Interaction Details

Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide is classified as belonging to the following category: Anticoagulant/Antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot. This is likely due to at least one of the known constituents of muellein, triterpenoid saponins. However, the effects appear to be mild and results have been inconsistent. Extracts from different plant parts have been show to have varying anticoagulant strengths, with water-based ones being more potent than alcohol-based extracts.

Interaction Rating

Likelihood of Occurrence

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Pharmacist Analysis

Mullein has been found to contain a variety of compounds, including glycosides, flavonoids, and phenylethanoid glycosides. It also contains triterpene saponins such as thapsuines, polysaccharides, phenolic acids, phytosterol glycosides, and digiprolactone.

Triterpene saponins have been noted in laboratory studies to have mild anticoagulant effects, although this effect has not been seen in humans. While it is unlikely that the relatively small amount of triterpene saponins in mullein will cause clinically significant anticoagulant effects, caution should be exercised.

References

• Triterpenoid saponins from Verbascum songaricum - PubMed
• Biological activity of common mullein, a medicinal plant - PubMed
• Saponins as Modulators of the Blood Coagulation System and Perspectives Regarding Their Use in the Prevention of Venous Thromboembolic Incidents - PubMed
  

Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide Overview

• Prescription aspirin is used to relieve the symptoms of rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), osteoarthritis (arthritis caused by breakdown of the lining of the joints), systemic lupus erythematosus (condition in which the immune system attacks the joints and organs and causes pain and swelling) and certain other rheumatologic conditions (conditions in which the immune system attacks parts of the body). Nonprescription aspirin is used to reduce fever and to relieve mild to moderate pain from headaches, menstrual periods, arthritis, toothaches, and muscle aches. Nonprescription aspirin is also used to prevent heart attacks in people who have had a heart attack in the past or who have angina (chest pain that occurs when the heart does not get enough oxygen). Nonprescription aspirin is also used to reduce the risk of death in people who are experiencing or who have recently experienced a heart attack. Nonprescription aspirin is also used to prevent ischemic strokes (strokes that occur when a blood clot blocks the flow of blood to the brain) or mini-strokes (strokes that occur when the flow of blood to the brain is blocked for a short time) in people who have had this type of stroke or mini-stroke in the past. Aspirin will not prevent hemorrhagic strokes (strokes caused by bleeding in the brain). Aspirin is in a group of medications called salicylates. It works by stopping the production of certain natural substances that cause fever, pain, swelling, and blood clots.

• Aspirin is also available in combination with other medications such as antacids, pain relievers, and cough and cold medications. This monograph only includes information about the use of aspirin alone. If you are taking a combination product, read the information on the package or prescription label or ask your doctor or pharmacist for more information.

Mullein - More Interactions

Mullein interacts with 121 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.