Oregon Grape - Minocycline Hydrochloride Interaction
Herbal: Oregon Grape
Also Known As: Mahonia aquifolium, Barberry, Berberis, Blue Barberry, Creeping Barberry, Holly Barberry, Holly Mahonia, Holly-Leaved Berberis, Mahonia, Mahonia Faux Houx, Mahonia à Feuilles de Houx, Mahonie, Mountain-Grape, Oregon Barberry, Oregon Grape-Holly, Scraperoot
Drug: Minocycline Hydrochloride
Brand names:
Ximino, Minolira
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
Minocycline Hydrochloride is classified as belonging to the following category: P-Glycoprotein Substrates
Theoretically, Oregon grape might increase serum levels of drugs that are P-glycoprotein (P-gp) substrates.
In vitro research suggests that Oregon grape extracts inhibit P-gp efflux.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Fan Y, Zhou Z, Zhang L. Effect of Oregon grape root extracts on P-glycoprotein mediated transport in in vitro cell lines. J Pharm Pharm Sci 2024;26:11927.
Oregon Grape Overview
Oregon grape (Mahonia aquifolium) is a perennial shrub that is native to the Pacific Northwest region of the United States, including Oregon and Washington. It is also found in parts of Canada. The plant is a member of the barberry family (Berberidaceae) and is closely related to the holly plant.
Oregon grape is often grown as an ornamental plant due to its attractive foliage and colorful berries. It is also used medicinally and is believed to have astringent, tonic, and anti-inflammatory properties. The root of the plant is used to make a herbal extract that is used to treat a variety of ailments, including skin conditions, digestive problems, and respiratory conditions. Most of the positive evidence for a medicinal effect is with topical applications as some research has shown topical preparations may modestly decrease the severity of psoriasis. It is important to note that the berries of the plant can be somewhat bitter and may contain toxins, so they should be eaten in moderation.
Minocycline Hydrochloride Overview
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Minocycline is used to treat infections caused by bacteria including pneumonia and other respiratory tract infections; certain infections of the skin, eye, lymphatic, intestinal, genital, and urinary systems; and certain other infections that are spread by ticks, lice, mites, and infected animals. It is also used along with other medications to treat acne. Minocycline is also used to treat plague and tuleramia (serious infections that may be spread on purpose as part of a bioterror attack). It can also be used in patients who cannot be treated with penicillin to treat certain types of food poisoning, and anthrax (a serious infection that may be spread on purpose as part of a bioterror attack). It can also be used to eliminate bacteria from your nose and throat that may cause meningitis (swelling of tissues around the brain) in others, even though you may not have an infection. Minocycline extended-release tablet (Solodyn) is only used to treat acne. Minocycline is in a class of medications called tetracycline antibiotics. It works to treat infections by preventing the growth and spread of bacteria. It works to treat acne by killing the bacteria that infects pores and decreasing a certain natural oily substance that causes acne.
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Antibiotics such as minocycline will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
Oregon Grape - More Interactions
Oregon Grape interacts with 1189 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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