Pumpkin - Eskalith (Lithium Carbonate (prescription drug)) Interaction
Herbal: Pumpkin
Also Known As: Cucurbita pepo, Calabaza, Citrouille, Cucurbitea Peponis Semen, Field Pumpkin, Graine de Citrouille, Great Pumpkin, Huile de Graines de Citrouille, Pepo, Pumpkin Seed Oil, Styrian Pumpkin
Drug: Lithium Carbonate (prescription drug)
Brand names:
Eskalith, Lithium Carbonate
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 22, 2025
Interaction Details
Lithium Carbonate (prescription drug) is classified as belonging to the following category: Lithium
Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
References
- Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 2015;94(3):286-95
Pumpkin Overview
Pumpkin is a type of squash native to North America. Pumpkin is a good source of nutrients, including vitamin A, vitamin C, potassium, and fiber. It is also a rich source of antioxidants, particularly beta-carotene, which is converted to vitamin A in the body.
Pumpkin has been used historically as a dietary supplement for supporting eye health, boosting the immune system, reducing the symptoms of benign prostatic hyperplasia, and helping to reduce the risk of certain types of cancer. Pumpkin is also a good source of fiber, which can help improve digestion and lower cholesterol levels.
Both pumpkin and pumpkin seed extracts have been utilized for dietary supplement purposes.
Lithium Carbonate (prescription drug) Overview
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Lithium is used to treat and prevent episodes of mania (frenzied, abnormally excited mood) in people with bipolar disorder (manic-depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods). Lithium is in a class of medications called antimanic agents. It works by decreasing abnormal activity in the brain.
Pumpkin - More Interactions
Pumpkin interacts with 1 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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