Puravive - Dextromethorphan, Pseudoephedrine Interaction
Herbal: Puravive
Drug: Dextromethorphan, Pseudoephedrine
Brand names:
Sudafed Cold/Flu
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Feb 05, 2024
Interaction Details
Dextromethorphan, Pseudoephedrine is classified as belonging to the following category: Cytochrome P450 2D6 (Cyp2D6) Substrates
Puravive contains Panax ginseng. Some research suggests that Panax ginseng might slow down the activity of an enzyme called CYP2D6 by about 6%. This enzyme plays a role in breaking down drugs in our system. One study (https://pubmed.ncbi.nlm.nih.gov/32557706/) found that Panax ginseng slows down the breakdown of dextromethorphan, a drug that is processed by CYP2D6, but only to a small extent. It is important to note that not all studies agree on these effects, and some suggest that Panax ginseng might not have a significant impact on CYP2D6 at all. Nevertheless, it's important to be cautious if you're taking medications that are processed by CYP2D6 and consider discussing it with your healthcare provider.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Interaction Details
Dextromethorphan, Pseudoephedrine is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates
Puravive contains Panax ginseng. Panax ginseng has the potential to affect the breakdown of drugs that are metabolized by an enzyme called CYP3A4. One example of such a drug is imatinib. There was a case where imatinib was thought to have caused liver damage, and it was believed that this might have been due to Panax ginseng inhibiting CYP3A4, which is involved in imatinib's metabolism (https://pubmed.ncbi.nlm.nih.gov/20332334/). On the other hand, Panax ginseng has been found to increase the breakdown of another drug called midazolam, which is also metabolized by CYP3A4 (https://pubmed.ncbi.nlm.nih.gov/21646440/), suggesting Panax ginseng induces CYP3A4 in some cases (i.e., makes more potent). Given these contradictory findings, it is important to use Panax ginseng cautiously if you are taking medications that are metabolized by CYP3A4, as the interaction between Panax ginseng and these drugs is not fully understood.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Interaction Details
Dextromethorphan, Pseudoephedrine is classified as belonging to the following category: Stimulant Drugs
Puravive contains Panax ginseng. Panax ginseng has demonstrated stimulant effects in some studies, which could potentially heighten the effects of other stimulant drugs (source: https://pubmed.ncbi.nlm.nih.gov/8879982/). It is unlikely this would result in a significant risk of side effects, but it is important to be aware of.
Interaction Rating
Likelihood of Occurrence
UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Puravive Overview
Puravive is a dietary supplement formulated with a blend of natural ingredients purported to support various aspects of health, with a specific focus on targeting and optimizing brown adipose tissue (BAT) levels in the body (which may help increase the rate at which calories are 'burned'). Puravive is marketed with claims related to brain health, cholesterol levels, cardiovascular function, stress reduction, immunity, digestion, and blood sugar regulation. Puravive contains several herbal ingredients, including Luteolin, Kudzu Root Extract, Holy Basil, White Korean Ginseng, Propolis, Quercetin, and Oleuropein.
Puravive - More Interactions
Puravive interacts with 1207 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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