Saffron - Ranexa (Ranolazine) Interaction
Herbal: Saffron
Also Known As: Crocus sativus, Autumn Crocus, Azafrán, Azafron, Croci Stigma, Crocin, Crocus Cultivé, Indian Saffron, Kashmira, Kesar, Kumkuma, Saffron Crocus, Safran, Safran Espagnol, Safran des Indes, Safran Véritable, Spanish Saffron, True Saffron, Zafran
Drug: Ranolazine
Brand names:
Ranexa, Aspruzyo
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Apr 27, 2025
Interaction Details
There were no interactions found between Ranolazine and Saffron. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Saffron Overview
Saffron is a spice derived from the dried stigmas of the crocus plant (Crocus sativus). It is native to Southwest Asia and is known for its distinctive golden-yellow color and unique, slightly bitter taste. Saffron is one of the most expensive spices in the world due to the labor-intensive process of harvesting and processing.
Saffron has been used traditionally in cooking and herbal medicine for centuries. It is purported to have a number of potential health benefits, including reducing inflammation, improving mood, improving memory, and reducing the risk of certain types of cancer, but more studies are needed to determine its effects.
Ranolazine Overview
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Ranolazine is used alone or with other medications to treat chronic angina (ongoing chest pain or pressure that is felt when the heart does not get enough oxygen). Ranolazine is in a class of medications called anti-anginals. The exact way that ranolazine works is not known at this time.
Saffron - More Interactions
Saffron interacts with 515 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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