Drug & supplement interaction

Salvia Divinorum + Interferon Beta-1a

Interferon Beta-1a brand names: Rebif, Avonex.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Salvia Divinorum and Interferon Beta-1a in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Salvia Divinorum and Interferon Beta-1a

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Interferon Beta-1a and Salvia Divinorum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Salvia Divinorum at all — not against Interferon Beta-1a, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Salvia Divinorum safety at a glance

Salvia Divinorum overall Avoid It is a potent hallucinogen with no established medical use and limited safety data; it is also restricted or illegal in many areas.
Pregnancy Avoid There is no safety data, and a hallucinogen should not be used during pregnancy.
Breastfeeding Avoid There is no safety data, so it should be avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Interferon Beta-1a and Salvia Divinorum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Salvia Divinorum Itself Has Been Linked To

This is not an interaction — nothing below involves Interferon Beta-1a. It is the side-effect record for Salvia Divinorum on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Salvia Divinorum, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Unsteadiness / Hallucinations / Confusion Worth acting on Additional detail

    “Orally or by inhalation, Salvia divinorum can cause hallucinogenic effects. These include restlessness, hyperactivity, disorientation, loss of coordination, dizziness, slurred speech, altered perceptions, changes in perception of body temperature, personal detachment or distorted body ownership, fatigue, severe mood changes, and psychosis. Most of these effects resolve within 20 minutes;”

    Salvia Divinorum · Natural Medicines adverse-effect record, reported in fatigue.

    6 sources cited
    1. 7350. Valdes LJ 3rd, Diaz JL, Paul AG. Ethnopharmacology of ska Maria Pastora (Salvia divinorum, Epling and Jativa-M.). J Ethnopharmacol 1983;7:287-312.
    2. 7351. Valdes LJ 3rd. Salvia divinorum and the unique diterpene hallucinogen, Salvinorin (divinorin) A. J Psychoactive Drugs 1994;26:277-83.
    3. 15820. Gonzalez D, Riba J, Bouso JC, et al. Pattern of use and subjective effects of Salvia divinorum among recreational users. Drug Alcohol Depend 2006;85:157-62. PubMed
    4. 72901. Bucheler, R., Gleiter, C. H., Schwoerer, P., and Gaertner, I. Use of nonprohibited hallucinogenic plants: increasing relevance for public health? A case report and literature review on the consumption of Salvia divinorum (Diviner's Sage). Pharmacopsychia
    5. 100001. Addy PH, Garcia-Romeu A, Metzger M, Wade J. The subjective experience of acute, experimentally-induced Salvia divinorum inebriation. J Psychopharmacol. 2015;29(4):426-35.
    6. 100002. El-Khoury J, Sahakian N. The association of Salvia divinorum and psychotic disorders: A review of the literature and case series. J Psychoactive Drugs. 2015;47(4):286-92.

    “Neurologic changes caused by Salvia divinorum are rapid, intense, and short-lived. Most evidence suggests a peak effect within 2 minutes following consumption by smoking, with a slower peak when consumed orally. Most symptoms cease within 20 minutes; however, the 'high' can last as long as 2 hours.”

    Salvia Divinorum · Natural Medicines adverse-effect record, reported in cluster headache.

    5 sources cited
    1. 7350. Valdes LJ 3rd, Diaz JL, Paul AG. Ethnopharmacology of ska Maria Pastora (Salvia divinorum, Epling and Jativa-M.). J Ethnopharmacol 1983;7:287-312.
    2. 7351. Valdes LJ 3rd. Salvia divinorum and the unique diterpene hallucinogen, Salvinorin (divinorin) A. J Psychoactive Drugs 1994;26:277-83.
    3. 15820. Gonzalez D, Riba J, Bouso JC, et al. Pattern of use and subjective effects of Salvia divinorum among recreational users. Drug Alcohol Depend 2006;85:157-62. PubMed
    4. 100001. Addy PH, Garcia-Romeu A, Metzger M, Wade J. The subjective experience of acute, experimentally-induced Salvia divinorum inebriation. J Psychopharmacol. 2015;29(4):426-35.
    5. 100002. El-Khoury J, Sahakian N. The association of Salvia divinorum and psychotic disorders: A review of the literature and case series. J Psychoactive Drugs. 2015;47(4):286-92.
  • Mood changes or irritability / Anxiety or restlessness Additional detail

    “Psychiatric changes caused by Salvia divinorum are rapid, intense, and short-lived. Most evidence suggests a peak effect within 2 minutes following consumption by smoking, with a slower peak when consumed orally. Most symptoms cease within 20 minutes; however, the 'high' can last as long as 2 hours.”

    Salvia Divinorum · Natural Medicines adverse-effect record, reported in anxiety.

    3 sources cited
    1. 72901. Bucheler, R., Gleiter, C. H., Schwoerer, P., and Gaertner, I. Use of nonprohibited hallucinogenic plants: increasing relevance for public health? A case report and literature review on the consumption of Salvia divinorum (Diviner's Sage). Pharmacopsychia
    2. 100001. Addy PH, Garcia-Romeu A, Metzger M, Wade J. The subjective experience of acute, experimentally-induced Salvia divinorum inebriation. J Psychopharmacol. 2015;29(4):426-35.
    3. 100002. El-Khoury J, Sahakian N. The association of Salvia divinorum and psychotic disorders: A review of the literature and case series. J Psychoactive Drugs. 2015;47(4):286-92.
  • Tiredness / Dizziness Additional detail

    Recorded for Salvia Divinorum in the same Natural Medicines adverse-effect record shown under Unsteadiness / Hallucinations / Confusion above.

  • Headache Additional detail

    Recorded for Salvia Divinorum in the same Natural Medicines adverse-effect record shown under Unsteadiness / Hallucinations / Confusion above.

  • Nausea Additional detail

    “Orally, Salvia divinorum can cause nausea.”

    Salvia Divinorum · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 7350. Valdes LJ 3rd, Diaz JL, Paul AG. Ethnopharmacology of ska Maria Pastora (Salvia divinorum, Epling and Jativa-M.). J Ethnopharmacol 1983;7:287-312.

Everything above comes from the Natural Medicines adverse-effect record for Salvia Divinorum — expand a row for the licensed statement it rests on. We haven’t matched Interferon Beta-1a to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Interferon Beta-1a.

Everything else you take

See Every Supplement That Interacts With Interferon Beta-1a

This page covers Salvia Divinorum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Interferon Beta-1a page lists 57 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (major), Siberian Cocklebur (major), Wine (major), Alfalfa (moderate) and Angelica Archangelica (moderate).

By severity: 3 major · 53 moderate · 1 minor.

From our pharmacist’s overview on the Interferon Beta-1a page

“Siberian cocklebur, an herb tied to documented cases of liver failure, is the first name to know for anyone injecting interferon beta-1a (Rebif, Avonex) for multiple sclerosis. Interferon beta-1a can strain the liver on its own, which is why prescribers order routine liver blood tests, and 38 of the 57 supplements on file carry that sa…”

Reviewed by 2 · Jul 18, 2026

Open the Interferon Beta-1a interaction page

How much people look this up

Where Salvia Divinorum and Interferon Beta-1a Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Salvia Divinorum
Steady interest

#1,188 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Interferon Beta-1a
Steady interest

#2,614 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Salvia Divinorum reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Salvia Divinorum and Interferon Beta-1a records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Salvia Divinorum

What is Salvia Divinorum?

  • Hallucinogenic or psychedelic experiences
  • Spiritual or ritual practices
  • Recreational use
  • Traditional Mazatec healing ceremonies

Salvia divinorum is a powerful hallucinogenic plant traditionally used by the Mazatec people of Mexico and now used recreationally for its short but intense mind-altering effects. There is no proven medical use, the safety is poorly studied, and it is illegal or restricted in many places. Because its effects can be unpredictable and disorienting, we do not recommend using it.

Salvia divinorum · Lamiaceae · Leaves · Dried leaves (smoked), chewed fresh leaves, leaf extracts, tinctures

An interaction check asks whether these two react with each other — it does not ask whether Salvia Divinorum is a good idea for someone in your situation. Here is what our Salvia Divinorum record says about it on its own.

Salvia Divinorum: dosing

There is no established or recommended safe dose for Salvia divinorum. The strength of leaves and extracts varies widely, and concentrated products can be far more potent than plain leaves, making effects hard to predict.Because it is not a proven medicine and is restricted in many areas, we cannot recommend any specific amount.

From our Salvia Divinorum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Salvia Divinorum monograph & all interactions
Medication

About Interferon Beta-1a Intramuscular Injection

What Is Interferon Beta-1a Intramuscular Injection Used For?

Brand names: Rebif, Avonex

  • Interferon beta-1a intramuscular injection is used to treat adults with various forms of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control) including:

    • clinically isolated syndrome (CIS; nerve symptom episodes that last at least 24 hours),

    • relapsing-remitting forms (course of disease where symptoms flare up from time to time), or

    • secondary progressive forms (course of disease where relapses occur more often).

  • Interferon beta-1a is in a class of medications called immunomodulators. It works by decreasing inflammation and preventing nerve damage that may cause symptoms of multiple sclerosis.

Most-Reported Side Effects for Interferon Beta-1a

From FAERS, the FDA’s public side-effect reporting system (192,069 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Multiple sclerosis relapse 15,851 reports
Influenza like illness 13,253 reports
Fatigue 11,554 reports
Fall 10,604 reports
Multiple sclerosis 9,358 reports
See full Interferon Beta-1a Intramuscular Injection drug information
Keep checking

Other Drugs & Salvia Divinorum

Browse every other medication we’ve checked against Salvia Divinorum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Salvia Divinorum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Salvia Divinorum list.

See the full Salvia Divinorum interactions page
See every supplement checked against Interferon Beta-1a, ranked by severity
Evidence & sources

Salvia Divinorum References

The 6 references that drive our Salvia Divinorum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Valdes LJ 3rd, Diaz JL, Paul AG. Ethnopharmacology of ska Maria Pastora (Salvia divinorum, Epling and Jativa-M.). J Ethnopharmacol 1983;7:287-312.
  2. Valdes LJ 3rd. Salvia divinorum and the unique diterpene hallucinogen, Salvinorin (divinorin) A. J Psychoactive Drugs 1994;26:277-83.
  3. Gonzalez D, Riba J, Bouso JC, et al. Pattern of use and subjective effects of Salvia divinorum among recreational users. Drug Alcohol Depend 2006;85:157-62. PubMed
  4. Bucheler, R., Gleiter, C. H., Schwoerer, P., and Gaertner, I. Use of nonprohibited hallucinogenic plants: increasing relevance for public health? A case report and literature review on the consumption of Salvia divinorum (Diviner's Sage). Pharmacopsychia
  5. Addy PH, Garcia-Romeu A, Metzger M, Wade J. The subjective experience of acute, experimentally-induced Salvia divinorum inebriation. J Psychopharmacol. 2015;29(4):426-35.
  6. El-Khoury J, Sahakian N. The association of Salvia divinorum and psychotic disorders: A review of the literature and case series. J Psychoactive Drugs. 2015;47(4):286-92.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Salvia Divinorum and Interferon Beta-1a Together: Common Questions

Is it safe to take Salvia Divinorum with Interferon Beta-1a?
We do not list a known interaction between Salvia Divinorum and Interferon Beta-1a. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Interferon Beta-1a interact with any supplements?
Yes. Interferon Beta-1a has documented interactions with 57 supplements in our database — Salvia Divinorum is not one of them. The Interferon Beta-1a interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Salvia Divinorum monograph Uses, safety profile, and every drug interaction in one place Interferon Beta-1a Intramuscular Injection drug information The full plain-English guide to this medication Interferon Beta-1a supplement interactions Every supplement checked against Interferon Beta-1a, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Interferon Beta-1a and Salvia Divinorum?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.