Drug & supplement interaction

Salvia Divinorum + Risedronate

Risedronate brand name: Actonel DR.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Salvia Divinorum and Risedronate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Salvia Divinorum and Risedronate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Risedronate and Salvia Divinorum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Salvia Divinorum at all — not against Risedronate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Salvia Divinorum safety at a glance

Salvia Divinorum overall Avoid It is a potent hallucinogen with no established medical use and limited safety data; it is also restricted or illegal in many areas.
Pregnancy Avoid There is no safety data, and a hallucinogen should not be used during pregnancy.
Breastfeeding Avoid There is no safety data, so it should be avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Risedronate and Salvia Divinorum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Salvia Divinorum and Risedronate May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Tiredness / Dizziness Additional detail

    Salvia Divinorum

    “Orally or by inhalation, Salvia divinorum can cause hallucinogenic effects. These include restlessness, hyperactivity, disorientation, loss of coordination, dizziness, slurred speech, altered perceptions, changes in perception of body temperature, personal detachment or distorted body ownership, fatigue, severe mood changes, and psychosis. Most of these effects resolve within 20 minutes;”

    Salvia Divinorum · Natural Medicines adverse-effect record, reported in fatigue.

    6 sources cited
    1. 7350. Valdes LJ 3rd, Diaz JL, Paul AG. Ethnopharmacology of ska Maria Pastora (Salvia divinorum, Epling and Jativa-M.). J Ethnopharmacol 1983;7:287-312.
    2. 7351. Valdes LJ 3rd. Salvia divinorum and the unique diterpene hallucinogen, Salvinorin (divinorin) A. J Psychoactive Drugs 1994;26:277-83.
    3. 15820. Gonzalez D, Riba J, Bouso JC, et al. Pattern of use and subjective effects of Salvia divinorum among recreational users. Drug Alcohol Depend 2006;85:157-62. PubMed
    4. 72901. Bucheler, R., Gleiter, C. H., Schwoerer, P., and Gaertner, I. Use of nonprohibited hallucinogenic plants: increasing relevance for public health? A case report and literature review on the consumption of Salvia divinorum (Diviner's Sage). Pharmacopsychia
    5. 100001. Addy PH, Garcia-Romeu A, Metzger M, Wade J. The subjective experience of acute, experimentally-induced Salvia divinorum inebriation. J Psychopharmacol. 2015;29(4):426-35.
    6. 100002. El-Khoury J, Sahakian N. The association of Salvia divinorum and psychotic disorders: A review of the literature and case series. J Psychoactive Drugs. 2015;47(4):286-92.

    “Neurologic changes caused by Salvia divinorum are rapid, intense, and short-lived. Most evidence suggests a peak effect within 2 minutes following consumption by smoking, with a slower peak when consumed orally. Most symptoms cease within 20 minutes; however, the 'high' can last as long as 2 hours.”

    Salvia Divinorum · Natural Medicines adverse-effect record, reported in cluster headache.

    5 sources cited
    1. 7350. Valdes LJ 3rd, Diaz JL, Paul AG. Ethnopharmacology of ska Maria Pastora (Salvia divinorum, Epling and Jativa-M.). J Ethnopharmacol 1983;7:287-312.
    2. 7351. Valdes LJ 3rd. Salvia divinorum and the unique diterpene hallucinogen, Salvinorin (divinorin) A. J Psychoactive Drugs 1994;26:277-83.
    3. 15820. Gonzalez D, Riba J, Bouso JC, et al. Pattern of use and subjective effects of Salvia divinorum among recreational users. Drug Alcohol Depend 2006;85:157-62. PubMed
    4. 100001. Addy PH, Garcia-Romeu A, Metzger M, Wade J. The subjective experience of acute, experimentally-induced Salvia divinorum inebriation. J Psychopharmacol. 2015;29(4):426-35.
    5. 100002. El-Khoury J, Sahakian N. The association of Salvia divinorum and psychotic disorders: A review of the literature and case series. J Psychoactive Drugs. 2015;47(4):286-92.

    Risedronate

    Listed in the ADVERSE REACTIONS section of the FDA label for Risedronate. Read the label on DailyMed ›

  • Headache Additional detail

    Salvia Divinorum

    Recorded for Salvia Divinorum in the same Natural Medicines adverse-effect record shown under Tiredness / Dizziness above.

    Risedronate

    Listed in the ADVERSE REACTIONS section of the FDA label for Risedronate. Read the label on DailyMed ›

  • Nausea Additional detail

    Salvia Divinorum

    “Orally, Salvia divinorum can cause nausea.”

    Salvia Divinorum · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 7350. Valdes LJ 3rd, Diaz JL, Paul AG. Ethnopharmacology of ska Maria Pastora (Salvia divinorum, Epling and Jativa-M.). J Ethnopharmacol 1983;7:287-312.

    Risedronate

    Listed in the ADVERSE REACTIONS section of the FDA label for Risedronate. Read the label on DailyMed ›

Reported for Salvia Divinorum but not commonly for Risedronate: unsteadiness, confusion, hallucinations and anxiety or restlessness.

Effects for Risedronate come from the ADVERSE REACTIONS section of its FDA label; effects for Salvia Divinorum come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Risedronate

This page covers Salvia Divinorum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Risedronate page lists 23 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Calcium (moderate), Coffee Charcoal (moderate), Dolomite (moderate) and European Mandrake (moderate).

By severity: 1 major · 13 moderate · 9 minor.

From our pharmacist’s overview on the Risedronate page

“Risedronate (Actonel DR) is an osteoporosis medicine with an Achilles heel, poor absorption. Only a small fraction of each dose ever reaches the bone, and the 23 supplements on this page deserve genuine wariness because nearly all of them attack that weak point by binding or blunting the drug in the gut.”

Reviewed by 2 · Jul 18, 2026

Open the Risedronate interaction page

How much people look this up

Where Salvia Divinorum and Risedronate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Salvia Divinorum
Steady interest

#929 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Risedronate
Top half

#1,247 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Salvia Divinorum reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Salvia Divinorum and Risedronate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Salvia Divinorum

What is Salvia Divinorum?

  • Hallucinogenic or psychedelic experiences
  • Spiritual or ritual practices
  • Recreational use
  • Traditional Mazatec healing ceremonies

Salvia divinorum is a powerful hallucinogenic plant traditionally used by the Mazatec people of Mexico and now used recreationally for its short but intense mind-altering effects. There is no proven medical use, the safety is poorly studied, and it is illegal or restricted in many places. Because its effects can be unpredictable and disorienting, we do not recommend using it.

Salvia divinorum · Lamiaceae · Leaves · Dried leaves (smoked), chewed fresh leaves, leaf extracts, tinctures

An interaction check asks whether these two react with each other — it does not ask whether Salvia Divinorum is a good idea for someone in your situation. Here is what our Salvia Divinorum record says about it on its own.

Salvia Divinorum: dosing

There is no established or recommended safe dose for Salvia divinorum. The strength of leaves and extracts varies widely, and concentrated products can be far more potent than plain leaves, making effects hard to predict.Because it is not a proven medicine and is restricted in many areas, we cannot recommend any specific amount.

From our Salvia Divinorum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Salvia Divinorum monograph & all interactions
Medication

About Risedronate

What Is Risedronate Used For?

Brand name: Actonel DR

Risedronate sodium tablets are used to treat and prevent osteoporosis in postmenopausal women, treat osteoporosis in men to increase bone mass, and treat and prevent osteoporosis caused by long-term steroid (glucocorticoid) use in both men and women. They are also used to treat Paget's disease of bone — a condition where bones break down and rebuild abnormally, becoming enlarged and weakened.

Risedronate sodium delayed-release tablets (brands Atelvia and Risedronate Sodium delayed-release) are approved specifically for the treatment of postmenopausal osteoporosis only — not for the other uses listed above.

See full Risedronate drug information
Keep checking

Other Drugs & Salvia Divinorum

Browse every other medication we’ve checked against Salvia Divinorum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Salvia Divinorum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Salvia Divinorum list.

See the full Salvia Divinorum interactions page
See every supplement checked against Risedronate, ranked by severity
Evidence & sources

Salvia Divinorum References

The 6 references that drive our Salvia Divinorum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Valdes LJ 3rd, Diaz JL, Paul AG. Ethnopharmacology of ska Maria Pastora (Salvia divinorum, Epling and Jativa-M.). J Ethnopharmacol 1983;7:287-312.
  2. Valdes LJ 3rd. Salvia divinorum and the unique diterpene hallucinogen, Salvinorin (divinorin) A. J Psychoactive Drugs 1994;26:277-83.
  3. Gonzalez D, Riba J, Bouso JC, et al. Pattern of use and subjective effects of Salvia divinorum among recreational users. Drug Alcohol Depend 2006;85:157-62. PubMed
  4. Bucheler, R., Gleiter, C. H., Schwoerer, P., and Gaertner, I. Use of nonprohibited hallucinogenic plants: increasing relevance for public health? A case report and literature review on the consumption of Salvia divinorum (Diviner's Sage). Pharmacopsychia
  5. Addy PH, Garcia-Romeu A, Metzger M, Wade J. The subjective experience of acute, experimentally-induced Salvia divinorum inebriation. J Psychopharmacol. 2015;29(4):426-35.
  6. El-Khoury J, Sahakian N. The association of Salvia divinorum and psychotic disorders: A review of the literature and case series. J Psychoactive Drugs. 2015;47(4):286-92.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Salvia Divinorum and Risedronate Together: Common Questions

Is it safe to take Salvia Divinorum with Risedronate?
We do not list a known interaction between Salvia Divinorum and Risedronate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Salvia Divinorum and Risedronate have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Risedronate interact with any supplements?
Yes. Risedronate has documented interactions with 23 supplements in our database — Salvia Divinorum is not one of them. The Risedronate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Salvia Divinorum monograph Uses, safety profile, and every drug interaction in one place Risedronate drug information The full plain-English guide to this medication Risedronate supplement interactions Every supplement checked against Risedronate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Risedronate and Salvia Divinorum?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.