Shark Liver Oil + Sodium Oxybate
Sodium Oxybate brand name: Xyrem.
We found no known interaction between Shark Liver Oil and Sodium Oxybate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sodium Oxybate states a food rule worth keeping to.
Shark Liver Oil and Sodium Oxybate
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Sodium Oxybate and Shark Liver Oil in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Shark Liver Oil at all — not against Sodium Oxybate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Shark Liver Oil safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Sodium Oxybate Products Have a Food Rule — Shark Liver Oil Should Not Break It
At least one FDA label for a product containing Sodium Oxybate says to take it with food. If you take Shark Liver Oil on an empty stomach out of habit, keep them separate — and take Sodium Oxybate with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sodium Oxybate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
• Allow 2 hours after eating before dosing ( 2.3 ).
From the Dosage and Administration section of the FDA label we read for Sodium Oxybate — where that label names a specific product, the instruction is that product's. See the Sodium Oxybate drug page ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
Questions About Shark Liver Oil or Sodium Oxybate
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Shark Liver Oil or Sodium Oxybate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Sodium Oxybate
This page covers Shark Liver Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sodium Oxybate page lists 25 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Biofeedback (moderate), Coffee Charcoal (moderate), Dendrobium (moderate) and European Mandrake (moderate).
By severity: 1 major · 15 moderate · 9 minor.
From our pharmacist’s overview on the Sodium Oxybate page
“Activated charcoal is the single major-rated interaction with sodium oxybate (Xyrem), and it earns that rating because the drug only works if each dose is fully absorbed; charcoal can bind it in the gut and weaken the nighttime control it provides for narcolepsy. Treat this list with genuine care, since 17 of the 25 ingredients on file…”
Reviewed by 2 · Jul 18, 2026
Taking Shark Liver Oil as Part of a Dietary Supplement Product? Check It for Interactions
We hold 20 real supplement products containing Shark Liver Oil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Shark Liver Oil. Even though Shark Liver Oil itself has no known interaction with Sodium Oxybate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Shark Liver Oil and Sodium Oxybate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,025 of 1,452 supplements looked up here in the last 7 days
#486 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Shark Liver Oil reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Shark Liver Oil and Sodium Oxybate records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Shark Liver Oil
What is Shark Liver Oil?
- Immune support
- Skin conditions and wound healing
- Cancer support (unproven)
- Hemorrhoid relief (topical)
- Cold and flu prevention
- General wellness tonic
Shark liver oil is taken from the livers of deep-sea sharks and is rich in compounds called alkylglycerols and squalene. People use it for immune support, skin healing, and other conditions, but strong human evidence is largely lacking. Talk to your pharmacist or doctor before using it, especially since sustainability and contamination are concerns.
Liver oil from deep-sea sharks · Capsules, softgels, liquid oil, topical creams and ointments
An interaction check asks whether these two react with each other — it does not ask whether Shark Liver Oil is a good idea for someone in your situation. Here is what our Shark Liver Oil record says about it on its own.
Shark Liver Oil: dosing
There is no official or well-established dose for shark liver oil. Products differ in how much alkylglycerol or squalene they contain, so amounts on labels vary.The safest approach is to follow the directions on the product label and not take more than recommended.
From our Shark Liver Oil monograph — the full record covers uses, side effects and every documented interaction.
About Sodium Oxybate
What Is Sodium Oxybate Used For?
Brand name: Xyrem
Sodium oxybate treats two major symptoms of narcolepsy: cataplexy (sudden muscle weakness triggered by emotion) and excessive daytime sleepiness (EDS). It is available in several products, each approved for these uses.
Xyrem (oral solution) and the generic sodium oxybate oral solution are approved for cataplexy or EDS in patients with narcolepsy. Lumryz (extended-release oral suspension) is specifically approved for cataplexy or EDS in patients 7 years of age and older with narcolepsy. The generic sodium oxybate oral solution label does not include the pediatric indication due to marketing exclusivity held by Xyrem.
Most-Reported Side Effects for Sodium Oxybate
From FAERS, the FDA’s public side-effect reporting system (65,536 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Shark Liver Oil
Browse every other medication we’ve checked against Shark Liver Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Shark Liver Oil against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Rivaroxaban ›
- Aspirin ›
- Acetaminophen ›
- Rosuvastatin ›
- Escitalopram ›
- Abemaciclib ›
- Clopidogrel ›
- Tadalafil ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Ibuprofen ›
- Tirzepatide ›
- Methamphetamine ›
- Hydroxyurea ›
- Semaglutide ›
- Warfarin Sodium ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Amitriptyline ›
- Methotrexate ›
- Bendamustine ›
- Acyclovir ›
- Doxycycline ›
- Fluoxetine ›
- Amphetamine ›
- Pregabalin ›
- Lamotrigine ›
- Azithromycin ›
- Acetaminophen, Codeine ›
- Isotretinoin ›
- Gabapentin ›
- Dextroamphetamine ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Clonazepam ›
- Omeprazole ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Shark Liver Oil list.
Shark Liver Oil References
The 6 references that drive our Shark Liver Oil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Lee JY, Lee KS, Kim TS, et al. Squalene-induced extrinsic lipoid pneumonia: serial radiologic findings in nine patients. J Comput Assist Tomogr 1999;23:730-5. PubMed
- Lee JS, Im JG, Song KS, et al. Exogenous lipoid pneumonia: high-resolution CT findings. Eur Radiol 1999;9:287-91. PubMed
- Asnis DS, Saltzman HP, Melchert A. Shark oil pneumonia. An overlooked entity. Chest 1993;103:976-7.
- Deniau AL, Mosset P, Pédrono F, Mitre R, Le Bot D, Legrand AB. Multiple beneficial health effects of natural alkylglycerols from shark liver oil. Mar Drugs. 2010 Jul 19;8(7):2175-84. PubMed
- Kilincalp S, Deveci M, Basar O, Ekiz F, Coban S, Yuksel O. Shark liver oil: hidden dangers. Ann Hepatol. 2012 Sep-Oct;11(5):728-30. DOI
- Hamadate N, Matsumoto Y, Seto K, Yamamoto T, Yamaguchi H, Nakagawa T, Yamamoto E, Fukagawa M, Yazawa K. Vascular effects and safety of supplementation with shark liver oil in middle-aged and elderly males. Exp Ther Med. 2015 Aug;10(2):641-646. Epub 2015 J PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Shark Liver Oil and Sodium Oxybate Together: Common Questions
Is it safe to take Shark Liver Oil with Sodium Oxybate?
Should I take Shark Liver Oil and Sodium Oxybate at the same time of day?
Does Sodium Oxybate interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.