Sodium Bicarbonate - Amphotericin, Tetracycline Interaction

Interaction Details

Amphotericin, Tetracycline is classified as belonging to the following category: Amphotericin-B (Abelcet, Others)

Theoretically, sodium bicarbonate may increase the risk for hypokalemia in patients receiving amphotericin B.
Orally, use of excessive sodium bicarbonate (such as the intake of "tablespoons" of sodium bicarbonate daily or up to one box of baking soda weekly) has been associated with cases of hypokalemia. Furthermore, when administered intravenously, the most common complication of sodium bicarbonate is hypokalemia. Amphotericin B increases urinary potassium losses due to toxic effects on renal tubular epithelium. Hypokalemia can occur in up to 50% of patients.

Interaction Rating

Likelihood of Occurrence

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

• Isaac G, Holland OB. Drug-induced hypokalamia: A cause for concern. Drugs & Aging 1992;2:35-41.
• Proudfoot, A. T., Krenzelok, E. P., and Vale, J. A. Position Paper on urine alkalinization. J Toxicol Clin Toxicol 2004;42(1):1-26.
• Fitzgibbons, L. J. and Snoey, E. R. Severe metabolic alkalosis due to baking soda ingestion: case reports of two patients with unsuspected antacid overdose. J Emerg Med 1999;17(1):57-61.

Sodium Bicarbonate - More Interactions

Sodium Bicarbonate interacts with 257 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.