Drug & supplement interaction

Sweet Cherry + Letrozole

Letrozole brand name: Femara.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Sweet Cherry and Letrozole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Sweet Cherry and Letrozole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Letrozole and Sweet Cherry in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Sweet Cherry at all — not against Letrozole, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sweet Cherry safety at a glance

Sweet Cherry overall Generally safe Sweet cherry is widely eaten as food and is generally well tolerated for most people.
Pregnancy Likely Safe When the fruit is consumed in amounts commonly found in foods. There is insufficient reliable information available about the safety of sweet cherry when used i... Read the full pregnancy detail
Breastfeeding Likely Safe When the fruit is consumed in amounts commonly found in foods. There is insufficient reliable information available about the safety of sweet cherry when used i... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Letrozole and Sweet Cherry? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Sweet Cherry Itself Has Been Linked To

This is not an interaction — nothing below involves Letrozole. It is the side-effect record for Sweet Cherry on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Sweet Cherry, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Shortness of breath / A severe allergic reaction / Hives / An allergic reaction Worth acting on Additional detail

    “Orally, sweet cherry can cause allergic reactions in sensitive patients. These reactions can range from mucosal irritation to urticaria, angioedema, dyspnea, cough, and gastrointestinal symptoms.”

    Sweet Cherry · Natural Medicines adverse-effect record, reported in cough.

    1 source cited
    1. 14057. Ballmer-Weber BK, Scheurer S, Fritsche P, et al. Component-resolved diagnosis with recombinant allergens in patients with cherry allergy. J Allergy Clin Immunol 2002;110:167-73. PubMed
  • Cough Additional detail

    Recorded for Sweet Cherry in the same Natural Medicines adverse-effect record shown under Shortness of breath / A severe allergic reaction / Hives / An allergic reaction above.

Everything above comes from the Natural Medicines adverse-effect record for Sweet Cherry — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Letrozole’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Letrozole column appears here.

Special populations

Sweet Cherry in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When the fruit is consumed in amounts commonly found in foods. There is insufficient reliable information available about the safety of sweet cherry when used in medicinal amounts during pregnancy or lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Sweet Cherry or Letrozole

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Sweet Cherry or Letrozole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Letrozole

This page covers Sweet Cherry only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Letrozole page lists 142 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), 7-methoxyflavone (moderate) and Acacia Rigidula (moderate).

By severity: 3 major · 99 moderate · 40 minor.

From our pharmacist’s overview on the Letrozole page

“Letrozole (Femara) is prescribed to keep hormone-driven breast cancer from returning, so a supplement that shifts its blood level can quietly undercut treatment. Give this list of 142 ingredients genuine respect, and learn the three major entries first.”

Reviewed by 2 · Jul 18, 2026

Open the Letrozole interaction page

One more smart check

Taking Sweet Cherry as Part of a Dietary Supplement Product? Check It for Interactions

We hold 493 real supplement products containing Sweet Cherry, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sweet Cherry. Even though Sweet Cherry itself has no known interaction with Letrozole, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Sweet Cherry and Letrozole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sweet Cherry
Top half

#722 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Letrozole
Top 5%

#51 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sweet Cherry reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Sweet Cherry and Letrozole records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Sweet Cherry

What is Sweet Cherry?

  • Joint pain and gout
  • Exercise recovery and muscle soreness
  • Sleep support
  • General antioxidant support
  • Inflammation

Sweet cherry (Prunus avium) is a popular fruit rich in antioxidants and natural plant pigments, and it is sometimes used as a supplement for gout, sore muscles, and sleep. The research that exists is mostly small or uses tart cherry rather than sweet cherry, so benefits are not well proven. Eaten as food, cherries are very safe, but talk to your pharmacist or doctor before using concentrated supplements.

Prunus avium · Rosaceae · Fruit (and fruit juice or extract); stems are used traditionally · Fresh or dried fruit, juice, juice concentrate, capsules, powders, and extracts

An interaction check asks whether these two react with each other — it does not ask whether Sweet Cherry is a good idea for someone in your situation. Here is what our Sweet Cherry record says about it on its own.

Sweet Cherry: dosing

There is no official or standardized dose for sweet cherry as a supplement. Studies have used different forms and amounts, and most used tart cherry, so the right dose for sweet cherry is not established.If you use a cherry juice, concentrate, powder, or capsule, follow the directions on the product label. Do not assume more is better.

From our Sweet Cherry monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sweet Cherry monograph & all interactions
Medication

About Letrozole

What Is Letrozole Used For?

Brand name: Femara

Letrozole (brand name Femara) is used to treat breast cancer in postmenopausal women whose tumors are driven by estrogen. It is used in three settings: as adjuvant (after-surgery) treatment for hormone receptor positive early breast cancer; as extended adjuvant treatment for women who have already completed about five years of tamoxifen therapy; and as first- or second-line treatment for locally advanced or metastatic (spread) breast cancer.

Femara is specifically indicated for first-line treatment of hormone receptor positive or receptor-unknown locally advanced or metastatic breast cancer, and for advanced breast cancer in women whose disease has progressed after antiestrogen therapy.

See full Letrozole drug information
Keep checking

Other Drugs & Sweet Cherry

Browse every other medication we’ve checked against Sweet Cherry — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Sweet Cherry against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Sweet Cherry list.

See the full Sweet Cherry interactions page
See every supplement checked against Letrozole, ranked by severity
Evidence & sources

Sweet Cherry References

The 3 references that drive our Sweet Cherry monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Serrano M, Guillen F, Martinez-Romero D, et al. Chemical constiuents and antioxidant activity of sweet cherry at different ripening stages. J Agric Food Chem 2005;53:2741-5.
  2. Ballmer-Weber BK, Scheurer S, Fritsche P, et al. Component-resolved diagnosis with recombinant allergens in patients with cherry allergy. J Allergy Clin Immunol 2002;110:167-73. PubMed
  3. Goncalves B, Landbo AK, Knudsen D, et al. Effect of ripeness and postharvest storage on the phenolic profiles of Cherries (Prunus avium L.). J Agric Food Chem 2004;52:523-30.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sweet Cherry and Letrozole Together: Common Questions

Is it safe to take Sweet Cherry with Letrozole?
We do not list a known interaction between Sweet Cherry and Letrozole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Letrozole interact with any supplements?
Yes. Letrozole has documented interactions with 142 supplements in our database — Sweet Cherry is not one of them. The Letrozole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sweet Cherry monograph Uses, safety profile, and every drug interaction in one place Letrozole drug information The full plain-English guide to this medication Letrozole supplement interactions Every supplement checked against Letrozole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Letrozole and Sweet Cherry?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.