Drug & supplement interaction

Sweet Cicely + Tafenoquine

Tafenoquine brand names: Krintafel, Arakoda.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Sweet Cicely and Tafenoquine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tafenoquine states a food rule worth keeping to.

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Interaction report

Sweet Cicely and Tafenoquine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tafenoquine and Sweet Cicely in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Sweet Cicely at all — not against Tafenoquine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sweet Cicely safety at a glance

Sweet Cicely overall Use caution Likely safe in small culinary amounts, but medicinal use is poorly studied.
Pregnancy Avoid Not enough safety data, so it is best avoided in medicinal amounts during pregnancy.
Breastfeeding Avoid Safety has not been studied, so avoid medicinal use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tafenoquine and Sweet Cicely? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Tafenoquine’s Own FDA Label Lists

This is not an interaction — none of it involves Sweet Cicely. These are the most notable effects listed in the ADVERSE REACTIONS section of Tafenoquine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Low mood Worth acting on mentioned in 28.6% of FDA reports for Tafenoquine
  • Loss of vision Worth acting on
  • Memory problems Worth acting on
  • Unsteadiness Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Fainting Worth acting on
  • A low platelet count Worth acting on
  • Kidney problems Worth acting on
  • Anemia Worth acting on
  • Hives Worth acting on

Showing the 10 most notable of 24 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Tafenoquine. Read the label on DailyMed › Where a percentage is shown, it is the share of 70 voluntary FDA FAERS reports for Tafenoquine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Sweet Cicely’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Sweet Cicely side to compare — that is a limit of the record, not a statement that Sweet Cicely has no side effects.

How to take them

Some Tafenoquine Products Have a Food Rule — Sweet Cicely Should Not Break It

At least one FDA label for a product containing Tafenoquine says to take it with food. If you take Sweet Cicely on an empty stomach out of habit, keep them separate — and take Tafenoquine with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tafenoquine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.1 ) Regimen Name Timing Dosage Loading regimen For each of the 3 days before travel to a malarious area 200 mg (2 of the 100 mg tablets) once daily for 3 days Maintenance regimen While in the malarious area 200 mg (2 of the 100 mg tablets) once weekly – start 7 days after the last loading regimen dose Terminal prophylaxis regimen In the week following exit from the malarious area 200 mg (2 of

From the Dosage and Administration section of the FDA label we read for Tafenoquine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Tafenoquine

This page covers Sweet Cicely only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tafenoquine page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Tafenoquine page

“Tafenoquine (Krintafel, Arakoda) protects against malaria, including the relapsing kind that hides in the liver, and every supplement known to interact with it threatens the same thing, how much of the pill actually reaches your blood. That deserves genuine care, since a partly absorbed antimalarial can let parasites survive and resurf…”

Reviewed by 2 · Jul 18, 2026

Open the Tafenoquine interaction page

How much people look this up

Where Sweet Cicely and Tafenoquine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sweet Cicely
Steady interest

#1,255 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tafenoquine
Steady interest

#2,240 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources.
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Sweet Cicely and Tafenoquine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Sweet Cicely

What is Sweet Cicely?

  • Digestive upset and gas
  • Mild cough and chest complaints
  • As a natural sweetener for tart foods
  • Loss of appetite
  • General tonic

Sweet Cicely is a mild, anise-flavored garden herb traditionally used in cooking and folk remedies for digestion and coughs. There is very little modern scientific research to confirm any health benefits, but it is generally considered safe in food amounts. Talk to a pharmacist or doctor before using it as a medicine, especially if you are pregnant or breastfeeding.

Myrrhis odorata · Apiaceae · Leaves, seeds, and roots · Fresh or dried herb, tea, culinary herb, occasionally tincture

An interaction check asks whether these two react with each other — it does not ask whether Sweet Cicely is a good idea for someone in your situation. Here is what our Sweet Cicely record says about it on its own.

Sweet Cicely: dosing

There is no established, standardized medicinal dose for Sweet Cicely. Most use is culinary, where the fresh or dried leaves and seeds are added to food or steeped as a mild tea.If you choose to use a commercial Sweet Cicely product, follow the directions on the product label and do not exceed the recommended amount.

From our Sweet Cicely monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sweet Cicely monograph & all interactions
Medication

About Tafenoquine

What Is Tafenoquine Used For?

Brand names: Krintafel, Arakoda

Tafenoquine is used for two distinct purposes depending on the product. Arakoda and Kodatef are used for malaria prophylaxis — that is, preventing malaria in adults 18 and older who are traveling to or living in areas where malaria is present.

Krintafel is used for the radical cure of Plasmodium vivax malaria — meaning it prevents the malaria parasite from coming back (relapsing) in patients 16 and older who are already being treated with chloroquine for an active P. vivax infection. Krintafel is not used to treat an active malaria attack on its own, and it should only be used alongside chloroquine, not other antimalarials.

Most-Reported Side Effects for Tafenoquine

From FAERS, the FDA’s public side-effect reporting system (70 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Depression 20 reports
Anxiety 18 reports
Post-traumatic stress disorder 15 reports
Anger 14 reports
Nausea 14 reports
See full Tafenoquine drug information
Keep checking

Other Drugs & Sweet Cicely

Browse every other medication we’ve checked against Sweet Cicely — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Sweet Cicely against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Sweet Cicely list.

See the full Sweet Cicely interactions page
See every supplement checked against Tafenoquine, ranked by severity
Sources

Sources & How We Checked

We checked Sweet Cicely against Tafenoquine in the Natural Medicines interaction database and found no documented interaction on file. The medication overview comes from MedlinePlus, and supplement label details from the NIH Dietary Supplement Label Database.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Sweet Cicely monograph › Uses, safety, and every drug interaction in one place Tafenoquine supplement interactions › Every supplement checked against Tafenoquine, ranked by severity Tafenoquine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Sweet Cicely and Tafenoquine Together: Common Questions

Is it safe to take Sweet Cicely with Tafenoquine?
We do not list a known interaction between Sweet Cicely and Tafenoquine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Sweet Cicely and Tafenoquine at the same time of day?
At least one FDA label for a product containing Tafenoquine says to take it with food. If you take Sweet Cicely on an empty stomach out of habit, keep them separate and take Tafenoquine with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Tafenoquine products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Tafenoquine interact with any supplements?
Yes. Tafenoquine has documented interactions with 17 supplements in our database — Sweet Cicely is not one of them. The Tafenoquine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Tafenoquine and Sweet Cicely?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.