Tree Turmeric - Ethinyl Estradiol, Norethindrone Interaction
Herbal: Tree Turmeric
Drug: Ethinyl Estradiol, Norethindrone
Brand names:
Femhrt, Loestrin 21, Ovcon 35 21, Ovcon 50 28, Necon 0.5 35 21, Tri Norinyl 21 Day, Brevicon 21 Day, Ortho-Novum 7/7/7 28, Jenest-28, Necon 1 35 21, Norinyl 1 35 21 Day, Ortho Novum 1 Plus 35, Modicon, Nelova 10/11, Norethin 1/35E, Norethin 1/35, Nelova 1/35, Norlestrin, Brevicon, Nelova 0.5/35 E, Synphasic 21 day, Synphasic 28 day, Brevicon .5/35 21 day, Brevicon .5/35 28 day, Select 1/35 21 day, Brevicon 1/35 28 day, Select 1/35 28 day, Brevicon 1/35 21 day, Demulen, Ortho-Novum, Junel 1/20, Junel Fe 1/20, Junel 1.5/30, Loestrin 21 1/20, Microgestin 1/20, Microgestin 1.5/30, Ovcon-35, Ovcon-35 Chewable, Necon 0.5/35, Necon 1/35, Necon 10/11, Necon 7/7/7, Nortrel 0.5/35, Norinyl 1+35, Nortrel 1/35, Nortrel 7/7/7, Ortho-Novum 1/35, Ortho-Novum 10/11, Ortho-Novum 7/7/7, Ovcon-50, Gencept 10/11, Aranelle, Leena, Tri-Norinyl, Loestrin 20, Loestrin 21 1.5/30
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 18, 2025
Interaction Details
Ethinyl Estradiol, Norethindrone is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of tree turmeric, moderately inhibits CYP3A4.
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
References
- Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72.
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82.
- Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217.
- Hermann, R. and von, Richter O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med 2012;78(13):1458-1477.
Tree Turmeric - More Interactions
Tree Turmeric interacts with 1134 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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