Drug & supplement interaction

Tylophora + Methylene Blue

Methylene Blue brand names: Urolene Blue, Provayblue.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Tylophora and Methylene Blue in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Tylophora and Methylene Blue

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Methylene Blue and Tylophora in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Tylophora at all — not against Methylene Blue, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tylophora safety at a glance

Tylophora overall Use caution Evidence is limited and the plant can cause nausea, vomiting, and other side effects.
Pregnancy Avoid Not enough safety data, and traditional concerns suggest it should be avoided in pregnancy.
Breastfeeding Avoid Safety during breastfeeding is unknown, so it is best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Methylene Blue and Tylophora? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Tylophora and Methylene Blue May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea Additional detail

    Tylophora

    “Orally, Tylophora might cause nausea, vomiting, change in taste, and mouth soreness.”

    Tylophora · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    5 sources cited
    1. 29118. Mathew KK, Shivpuri DN. Treatment of asthma with alkaloids of Tylophora indica - a double blind study. Aspects of Allergy Appl Immunol 1974;7:166-179.
    2. 29119. Gupta S, George P, Gupta V, et al. Tylophora indica in bronchial asthma--a double blind study. Indian J Med Res 1979;69:981-989.
    3. 29120. Shivpuri DN, Menon MP, Prakash D. A crossover double-blind study on Tylophora indica in the treatment of asthma and allergic rhinitis. J Allergy 1969;43(3):145-150.
    4. 29121. Shivpuri DN, Menon MP, Parkash D. Preliminary studies in Tylophora indica in the treatment of asthma and allergic rhinitis. J Assoc Physicians India 1968;16(1):9-15.
    5. 29122. Shivpuri DN, Singhal SC, Parkash D. Treatment of asthma with an alcoholic extract of tylophora indica: a cross-over, double-blind study. Ann Allergy 1972;30(7):407-412.

    “Orally, Tylophora leaf has been reported to cause nausea in up to 10.8% of patients, vomiting in up to 16.6% of patients, mild upper abdominal pain in up to 5.6% of patients, and soreness of the mouth or loss of taste in up to 1.4% of patients in clinical research.”

    Tylophora · Natural Medicines adverse-effect record, reported in hypogeusia.

    5 sources cited
    1. 29118. Mathew KK, Shivpuri DN. Treatment of asthma with alkaloids of Tylophora indica - a double blind study. Aspects of Allergy Appl Immunol 1974;7:166-179.
    2. 29119. Gupta S, George P, Gupta V, et al. Tylophora indica in bronchial asthma--a double blind study. Indian J Med Res 1979;69:981-989.
    3. 29120. Shivpuri DN, Menon MP, Prakash D. A crossover double-blind study on Tylophora indica in the treatment of asthma and allergic rhinitis. J Allergy 1969;43(3):145-150.
    4. 29121. Shivpuri DN, Menon MP, Parkash D. Preliminary studies in Tylophora indica in the treatment of asthma and allergic rhinitis. J Assoc Physicians India 1968;16(1):9-15.
    5. 29122. Shivpuri DN, Singhal SC, Parkash D. Treatment of asthma with an alcoholic extract of tylophora indica: a cross-over, double-blind study. Ann Allergy 1972;30(7):407-412.

    Methylene Blue

    Listed in the ADVERSE REACTIONS section of the FDA label for Methylene Blue. Read the label on DailyMed ›

Reported for Tylophora but not commonly for Methylene Blue: stomach pain, a change in taste, mouth irritation or sores and vomiting.

Effects for Methylene Blue come from the ADVERSE REACTIONS section of its FDA label; effects for Tylophora come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Methylene Blue

This page covers Tylophora only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methylene Blue page lists 38 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Lithium (major), 5-htp (moderate), Acetyl-l-carnitine (moderate) and Ayahuasca (moderate).

By severity: 2 major · 25 moderate · 11 minor.

From our pharmacist’s overview on the Methylene Blue page

“The pairing I would worry about first with methylene blue (Urolene Blue, Provayblue) is anything that raises serotonin, and lithium heads that group with a major rating. Methylene blue inhibits monoamine oxidase A, the enzyme that breaks serotonin down, so combining it with serotonin-boosting supplements can tip someone into serotonin…”

Reviewed by 2 · Jul 18, 2026

Open the Methylene Blue interaction page

How much people look this up

Where Tylophora and Methylene Blue Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tylophora
Steady interest

#1,159 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Methylene Blue
Top 5%

#53 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tylophora reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Tylophora and Methylene Blue records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tylophora

What is Tylophora?

  • Asthma
  • Allergies and hay fever
  • Bronchitis and respiratory complaints
  • Inflammatory conditions
  • Digestive upset

Tylophora is a climbing plant used in traditional Indian (Ayurvedic) medicine, most often for asthma and breathing problems. Some older, small studies suggested possible benefit for asthma, but the evidence is weak and limited, and the plant can cause notable side effects. Talk to your pharmacist or doctor before trying it, and never use it to replace proven asthma treatments.

Tylophora indica · Apocynaceae · Leaves and roots · Capsules, dried leaf powder, tinctures, and traditional leaf preparations

An interaction check asks whether these two react with each other — it does not ask whether Tylophora is a good idea for someone in your situation. Here is what our Tylophora record says about it on its own.

Tylophora: dosing

There is no well-established or standardized dose for Tylophora. Older studies used small amounts of dried leaf for short periods, but these doses have not been confirmed as safe or effective.If you choose to use a product, follow the directions on the label and do not exceed them.

From our Tylophora monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tylophora monograph & all interactions
Keep checking

Other Drugs & Tylophora

Browse every other medication we’ve checked against Tylophora — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Tylophora against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Tylophora list.

See the full Tylophora interactions page
See every supplement checked against Methylene Blue, ranked by severity
Evidence & sources

Tylophora References

The 6 references that drive our Tylophora monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Thiruvengadam KV, Haranath K, Sudarsan S, et al. Tylophora indica in bronchial asthma (a controlled comparison with a standard anti-asthmatic drug). J Indian Med Assoc 1978;71(7):172-176.
  2. Mathew KK, Shivpuri DN. Treatment of asthma with alkaloids of Tylophora indica - a double blind study. Aspects of Allergy Appl Immunol 1974;7:166-179.
  3. Gupta S, George P, Gupta V, et al. Tylophora indica in bronchial asthma--a double blind study. Indian J Med Res 1979;69:981-989.
  4. Shivpuri DN, Menon MP, Prakash D. A crossover double-blind study on Tylophora indica in the treatment of asthma and allergic rhinitis. J Allergy 1969;43(3):145-150.
  5. Shivpuri DN, Menon MP, Parkash D. Preliminary studies in Tylophora indica in the treatment of asthma and allergic rhinitis. J Assoc Physicians India 1968;16(1):9-15.
  6. Shivpuri DN, Singhal SC, Parkash D. Treatment of asthma with an alcoholic extract of tylophora indica: a cross-over, double-blind study. Ann Allergy 1972;30(7):407-412.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tylophora and Methylene Blue Together: Common Questions

Is it safe to take Tylophora with Methylene Blue?
We do not list a known interaction between Tylophora and Methylene Blue. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Tylophora and Methylene Blue have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Methylene Blue interact with any supplements?
Yes. Methylene Blue has documented interactions with 38 supplements in our database — Tylophora is not one of them. The Methylene Blue interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tylophora monograph Uses, safety profile, and every drug interaction in one place Methylene Blue supplement interactions Every supplement checked against Methylene Blue, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Methylene Blue and Tylophora?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.