Wild Lettuce - Remicade (Infliximab) Interaction
Herbal: Wild Lettuce
Also Known As: Lactuca virosa, Acrid Lettuce, Allubbyne, Bitter Lettuce, German Lactucarium, Green Endive, Lactucarium, Laitue Amère, Laitue à Opium, Laitue Sauvage, Laitue Scariole, Laitue Serriole, Laitue Vireuse, Lechuga Silvestre, Lettuce Opium, Poison Lettuce
Drug: Infliximab
Brand names:
Remicade
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
There were no interactions found between Infliximab and Wild Lettuce. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Pharmacist Analysis
Studies are few and far between, but the only reported interactions with wild lettuce are with sedative drugs as wild lettuce is purported to have sedative effects.
This would include drugs like antihistamines, opioids, and benzodiazepines. These are detailed on our individual drug interaction pages.
Additionally, as wild lettuce may contain hyoscyamine, an anticholinergic drug, it should be used cautiously with other anticholinergic drugs due to the increased risk of side effects.
Wild Lettuce Overview
Wild lettuce (Lactuca virosa) is a plant species in the lettuce family that is native to Europe and parts of Asia. It is a tall, annual plant with small, yellow flowers and leaves that resemble the leaves of cultivated lettuce. Wild lettuce is sometimes called "opium lettuce" due to the milky sap it contains that has been purported to have sedative and analgesic effects.
Wild lettuce has a long history of use in traditional medicine. It is thought to have various medicinal properties, including sedative, analgesic, and antispasmodic effects. It is used to treat a variety of conditions, including insomnia, anxiety, and pain.
Infliximab Overview
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Infliximab injection products are used to relieve the symptoms of certain autoimmune disorders (conditions in which the immune system attacks healthy parts of the body and causes pain, swelling, and damage) including:
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rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function) that is also being treated with methotrexate (Rheumatrex, Trexall),
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Crohn's disease (a condition in which the body attacks the lining of the digestive tract, causing pain, diarrhea, weight loss, and fever) in adults and children 6 years of age or older that has not improved when treated with other medications,
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ulcerative colitis (condition that causes swelling and sores in the lining of the large intestine) in adults and children 6 years of age or older that has not improved when treated with other medications,
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ankylosing spondylitis (a condition in which the body attacks the joints of the spine and other areas causing pain and joint damage),
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plaque psoriasis (a skin disease in which red, scaly patches form on some areas of the body) in adults when other treatments are less appropriate,
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and psoriatic arthritis (a condition that causes joint pain and swelling and scales on the skin).
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Infliximab injection products are in a class of medications called tumor necrosis factor-alpha (TNF-alpha) inhibitors. They work by blocking the action of TNF-alpha, a substance in the body that causes inflammation.
Wild Lettuce - More Interactions
Wild Lettuce interacts with 390 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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