Alchemilla Interactions Overview

Alchemilla, a perennial herb found throughout Europe, is traditionally used orally for gastrointestinal issues, inflammation, and as a diuretic. Its above-ground parts are also used topically for their astringent properties. Alchemilla contains 6-16% tannins (ellagic and gallic acids) and 2.22% flavonoids (quercetin, luteolin, and proanthocyanidins). Studies show that alchemilla's aqueous extracts have antioxidant effects, countering lipid peroxidation and scavenging superoxide anions. In dermatology, alchemilla extracts inhibit proteolytic enzymes and promote fibroblast migration, potentially aiding in wound healing. A small human study suggests that alchemilla extract in gels improves skin moisturization, particularly when skin is pre-treated with drying agents like sodium laurel sulfate, although the exact mechanism is unclear. Most dietary supplements that contain Alchemilla refer to it solely as 'Lady's Mantle'.