Black Pepper Interactions Overview

Check For Interactions With Black Pepper

Black Pepper

Also known as
  • Piper nigrum
  • Black Peppercorn
  • Extrait de Poivre
  • Grain de Poivre
  • Hu Jiao
  • Kali Mirchi
  • Kosho
  • Marich
  • Maricha
  • Miris
  • Peber
  • Peper
  • Pepe
  • Peppar
  • Pepper
  • Pepper Extract
  • Peppercorn
  • Pfeffer
  • Pimenta
  • Pimienta
  • Pimienta Negra
  • Pipar
  • Piper
  • Piperine
  • Pippuri
  • Poivre
Black Pepper Black pepper is a spice made from the dried, unripe fruit of the Piper nigrum plant, which is native to the southwestern coast of India. It is one of the most widely used spices in the world, and it is often utilized to add flavor and heat to a wide variety of dishes. In traditional medicine, black pepper is purported to have a number of health benefits. It is a good source of antioxidants and is thought to have anti-inflammatory properties, which may make it useful in reducing inflammation and swelling in the body. Black pepper is also used as a natural remedy for digestive problems, such as indigestion and bloating, and to boost the immune system. Black pepper is widely used in dietary supplements, specifically, an extract from black pepper known as piperine. Piperine can affect the absorption of many drugs, which is why it has a large number of reported interactions. Oftentimes, these 'interactions' are purposeful, such as when piperine is used with turmeric, to increase its absorption.
There are 949 drugs known to interact with Black Pepper

Additional Details

Is Black Pepper Safe? Are There Any Warnings?

Black pepper is generally considered safe when used in cooking. However, excessive consumption can be harmful, particularly in children. There have been cases of accidental overdose leading to serious respiratory issues and, in rare cases, death. Moderation is crucial, especially around young children.

How Does Black Pepper Work? What's the Mechanism of Action?

Black pepper offers various potential health benefits:

  • Antibacterial Effects: Compounds in black pepper can combat certain bacteria, acting as a natural antimicrobial agent.
  • Antidiabetic Effects: Specific components may help lower blood sugar levels, making it relevant for diabetes management.
  • Antioxidant Effects: Rich in antioxidants, black pepper defends cells against damage from free radicals.
  • Cancer Protection: Evidence suggests it may protect against certain cancers, especially colon cancer, though conflicting studies exist.
  • Enhancing Cognitive Function: Piperine, found in black pepper, is being researched for potential cognitive improvement.
  • Skin Benefits: Black pepper extract may promote skin pigmentation and wound healing, while black pepper oil could have positive effects on skin cancer cells.
  • Enhancing Drug Absorption: Piperine enhances the absorption of certain medications and substances.
  • Gastrointestinal and Metabolic Effects: Black pepper may stimulate gastric secretions, aid digestion, and influence metabolism.
  • Insecticidal Properties: Black pepper essential oil displays insecticidal effects against various pests.
  • Weight Management: Some studies suggest black pepper components might moderately affect satiety and metabolism, potentially aiding weight management.

Pharmacokinetics

Limited information exists regarding how black pepper is absorbed, metabolized, and excreted. More research is required for a comprehensive understanding of its pharmacokinetics.

Interaction Overview (Full List Below)

Black pepper may interact with certain herbs, supplements, and medical conditions. It might impact blood clotting and blood sugar levels. Consultation with a healthcare provider is advisable before using black pepper supplements, especially when taking medications or having specific health conditions.

Common Side Effects to Watch For

Usual culinary amounts of black pepper are well-tolerated. However, excessive consumption could lead to discomfort or gastrointestinal issues. Rare cases of severe respiratory problems resulting from excessive consumption, particularly in children, have been reported.

Are Supplements Standardized?

Black pepper supplements vary in content and quality. Some products offer standardized amounts of compounds like piperine, while others might not. Choose reputable brands and seek advice from a healthcare professional before incorporating black pepper supplements.

What Is Black Pepper Typically Used For?

Black pepper is a common spice in cooking. Beyond its culinary use, ongoing research explores its potential health benefits. These encompass potential antimicrobial, antioxidant, antidiabetic, and cognitive-enhancing properties. Some studies also suggest roles in weight management and skin health. 

Drugs that interact with Black Pepper

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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