Bromelain Interactions Overview
Check For Interactions With Bromelain
Bromelain

Additional Details
Is Bromelain Safe? Are There Any Warnings?
Bromelain is generally safe for oral and topical use when taken appropriately. Oral doses of up to 240 mg daily for up to a year have been used safely. Short-term use of up to 3200 mg daily has also been deemed safe.When used topically, bromelain has been used safely as a debriding agent for up to 4 hours. However, there is insufficient reliable information available regarding the safety of using bromelain during pregnancy and lactation.
The most common adverse effects include diarrhea and gastric upset when taken orally, and pruritus and urticaria when used topically.
How Does Bromelain Work? What is the Mechanism of Action?
Bromelain is a proteolytic enzyme derived from pineapples. It exerts its effects through various mechanisms.The anti-inflammatory effects of bromelain are thought to be due to its ability to alter leukocyte activation, inhibit prostaglandin and bradykinin synthesis, and increase the release of reactive oxygen species.
Bromelain has also been found to have cytotoxic effects and can suppress the growth of leukemia cancer cells. In dermatology, bromelain is commonly used for wound debridement due to its ability to break down proteins and promote healing. It may also have antiviral and immunomodulating effects.
Additionally, bromelain can prevent gastrointestinal fluid secretion induced by certain toxins and may help prevent diarrhea caused by Escherichia coli. It can also inhibit platelet aggregation and possess fibrinolytic activity, which can have anticancer effects.
Pharmacokinetics
When taken orally, bromelain is absorbed slowly and reaches peak concentrations between 24 and 51 hours.It has a low bioavailability in humans (2-4%) but can have higher bioavailability in some animals (up to 40%).
Bromelain is distributed in plasma and blood and has an elimination half-life of 6-9 hours. It may increase the permeability of the intestinal mucosal epithelium, facilitating its own absorption by self-enhanced paracellular diffusion.
Interaction Overview
Bromelain may interact with certain medications and supplements. It may increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs. There is also a potential for bromelain to increase the levels of tetracycline antibiotics. Additionally, bromelain may have interactions with certain herbs and supplements, such as those with anticoagulant/antiplatelet effects or zinc.Common Side Effects to Watch For
The most common side effects of bromelain include diarrhea and gastric upset when taken orally, and pruritus and urticaria when used topically. These side effects are generally well-tolerated.Are Bromelain Supplements Standardized?
Bromelain products are typically standardized based on their enzymatic activity. The enzymatic activity of bromelain is measured using various units such as Rorer units, FIP units, CDU, MCU, or GDU. Standardization ensures that the product contains a consistent level of enzymatic activity, allowing users to know the potency of the bromelain supplement they are taking.Drugs that interact with Bromelain
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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