Herb & supplement monograph

Heart's Ease Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with Heart's Ease

0 medications have a known interaction with Heart's Ease, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Heart's Ease. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Heart's Ease combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Heart's Ease: Uses, Safety & Side Effects

The bottom line

Heart's Ease (Viola tricolor) is a traditional European herb used mostly for skin problems and mild coughs. Modern human evidence for these uses is very limited, so it should be seen as a gentle traditional remedy rather than a proven treatment. Talk to your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or giving it to a child.

Scientific name
Viola tricolor
Family
Violaceae
Part used
Above-ground flowering parts (herb)
Common forms
Tea, dried herb, tincture, topical preparations, capsules
People commonly use it for
  • Skin conditions like eczema and cradle cap
  • Mild respiratory complaints (cough)
  • Mild inflammation
  • Diuretic (increasing urine flow)
  • General 'blood cleansing' tonic

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally considered low-risk in traditional use, but high-quality safety data are limited.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Heart's Ease is the common name for Viola tricolor, a small flowering plant in the violet family. It is also sometimes called wild pansy. It grows across Europe and parts of Asia and is now found in many other temperate regions, often in fields, gardens, and along roadsides.

The above-ground flowering parts of the plant have a long history in European folk medicine. People have traditionally used it as a tea or in skin preparations. Today it is sold as a dried herb, tea, tincture, and in some topical products.

How it works

Heart's Ease contains several plant compounds, including flavonoids (such as rutin), mucilage (a slippery, soothing substance), salicylates, and small ring-shaped peptides called cyclotides.

Researchers think the mucilage may help soothe irritated tissue, while flavonoids and other compounds may have mild antioxidant or anti-inflammatory effects. It is important to know that most of these ideas come from laboratory or test-tube research, not from well-designed human studies. The way it might work in people is still not well understood.

Effectiveness

Does Heart's Ease work?

Evidence overview · 2 uses evaluated
2 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Heart's Ease, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 2 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Atopic dermatitis (eczema)
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research shows that applying an ointment containing 5% each of the extracts of heart's ease, gotu kola, and Oregon grape twice daily for 4 weeks does not improve eczema when compared with a base cream. However, patients with eczema on skin exposed to cold weather might experience some improvement.

Sources Ref 67372
Insufficient Reliable Evidence To Rate Chronic obstructive pulmonary disease (COPD)
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research in men aged 40-70 years with a history of smoking and stage 2 COPD shows that taking a combination of heart's ease 165 mg, calendula flowers 165 mg, and elderberry 165 mg (Inflaminat, INAT-Farma), 3 capsules daily for 6 months, modestly improves the score on the 5-point breathlessness, cough, and sputum scale (BCSS) and the mean forced expiratory volume in 1 second (FEV1), compared with no changes in the placebo group. However, the number of COPD exacerbations per month does not seem to be affected. It is unclear if these effects are due to heart's ease, other ingredients, or the combination.

Sources Ref 103629

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

In traditional use, Heart's Ease is generally regarded as gentle and low-risk when used short-term in normal amounts. However, modern, high-quality safety studies are limited, so we cannot be certain about all situations.

People with known allergies to plants in the violet family should be cautious. Because it may act as a mild diuretic, people with kidney problems or those taking medicines that affect fluid balance should check with a healthcare provider first.

Pregnancy and breastfeeding: There is not enough reliable safety information, so Heart's Ease is best avoided during pregnancy and while breastfeeding. Before giving it to a child (for example for cradle cap), talk to a pediatrician or pharmacist.

Side effects

Heart's Ease is usually well tolerated in traditional amounts, and reported side effects are uncommon. Possible effects include mild stomach upset and, rarely, allergic skin reactions when used on the skin.

Stop using it and seek medical care if you notice signs of an allergic reaction, such as a spreading rash, swelling, or trouble breathing. As with any supplement, quality and purity can vary between products.

Heart's Ease: Reported Adverse Effects

Documented safety reports on Heart's Ease from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, heart's ease seems to be generally well tolerated. It has caused hemolysis in a nine-month-old infant with glucose-6-phosphate-dehydrogenase (G6PD) deficiency.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Behmanesh Y, Abdollahi M. Hemolysis after consumption of Viola tricolor. WHO Drug Inf (Iran) 2002;16:15-16.
Reports by condition
Glucose-6-phosphate dehydrogenase (G6PD) deficiency Hematologic

Orally, heart's ease boiled extract has caused hemolysis in a nine-month-old infant with glucose-6-phosphate-dehydrogenase (G6PD) deficiency. The methyl ester of salicylic acid, a constituent of heart's ease, is hypothesized to be responsible for this effect.

  1. Behmanesh Y, Abdollahi M. Hemolysis after consumption of Viola tricolor. WHO Drug Inf (Iran) 2002;16:15-16.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no well-established, standardized dose for Heart's Ease. Traditional use varies widely depending on whether it is taken as a tea, tincture, or applied to the skin.

The safest approach is to follow the directions on the product label and to start with the lowest suggested amount. Because products differ in strength, talk to a pharmacist or doctor before using it, and do not use it for long periods without professional advice.

Pregnancy & Breastfeeding

Heart's Ease & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Heart's Ease & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 4 references that drive our Heart's Ease monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Behmanesh Y, Abdollahi M. Hemolysis after consumption of Viola tricolor. WHO Drug Inf (Iran) 2002;16:15-16.
  3. Klovekorn, W., Tepe, A., and Danesch, U. A randomized, double-blind, vehicle-controlled, half-side comparison with a herbal ointment containing Mahonia aquifolium, Viola tricolor and Centella asiatica for the treatment of mild-to-moderate atopic dermatit
  4. Kirichenko TV, Sobenin IA, Markina YV, et al. Clinical effectiveness of a combination of black elder berries, violet herb, and calendula flowers in chronic obstructive pulmonary disease: the results of a double-blinded placebo-controlled study. Biology (B PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Heart's Ease: Common Questions

What is Heart's Ease used for, and does it work?
People use Heart's Ease for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Heart's Ease interact with prescription medications?
We do not currently list any known drug interactions for Heart's Ease. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Heart's Ease interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Heart's Ease with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Heart's Ease interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Heart's Ease used for?
It is traditionally used for mild skin problems like eczema and cradle cap, for mild coughs, and as a gentle diuretic. Strong human evidence for these uses is lacking.
Is Heart's Ease safe to take?
It is generally considered gentle in traditional, short-term use, but good-quality safety data are limited. Check with a pharmacist or doctor before using it, especially if you have a health condition.
Can I use Heart's Ease during pregnancy or while breastfeeding?
It is best avoided during pregnancy and breastfeeding because there is not enough reliable information to confirm it is safe.
Can I put Heart's Ease on my child's skin?
It has been used traditionally for cradle cap, but you should talk to a pediatrician or pharmacist before using it on a baby or child.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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