Mangosteen Interactions Overview
Check For Interactions With Mangosteen
Mangosteen
- Garcinia mangostana
- Amibiasine
- Fruit des Rois
- Jus de Xango
- Mang Cut
- Manggis
- Manggistan
- Mangosta
- Mangostan
- Mangostán
- Mangostana
- Mangostanier
- Mangostao
- Mangostier
- Mangoustan
- Mangoustanier
- Mangouste
- Mangoustier
- Manguita
- Meseter
- Queen of Fruit
- Queen of Fruits

Additional Details
Is Mangosteen Safe? Are There Any Warnings?
Mangosteen, a fruit from Southeast Asia, is considered generally safe when taken orally or applied topically. It has been used without apparent issues at recommended doses for up to 12 weeks. However, caution is advised during pregnancy and lactation due to insufficient reliable information.
How Does Mangosteen Work? What is the Mechanism of Action?
Mangosteen's medicinal properties are linked to xanthones, compounds found in the fruit's pericarp. These xanthones, including alpha- and gamma-mangostin, possess anti-allergy, antibacterial, anti-inflammatory, antioxidant, and anti-proliferative properties. They work by blocking histamine receptors, inhibiting inflammatory responses, and inducing apoptosis in cancer cells, among other mechanisms.
Pharmacokinetics
When consumed, mangosteen is absorbed into the body, and its xanthones undergo glucuronidation and sulfation during metabolism. The compounds are primarily excreted through feces, with a minimal amount excreted through urine. The bioavailability of mangosteen depends on its incorporation into bile salt micelles.
Interaction Overview
Mangosteen may interact with anticoagulant/antiplatelet drugs, potentially increasing the risk of bleeding. Additionally, caution is advised when using mangosteen with medications like donepezil (Aricept) as it might enhance their effects.
Common Side Effects to Watch For
Generally, mangosteen is well-tolerated orally and topically, with no reported adverse effects. However, serious adverse effects like lactic acidosis are rare. Individuals should remain vigilant for any unexpected reactions.
Are Supplements Standardized?
Mangosteen supplements may vary in composition and concentration. Some clinical studies have used specific formulations with standardized levels of alpha-mangostin and hydroxycitric acid, ensuring consistency in their effects.
What Is Mangosteen Typically Used For?
Mangosteen is used for various purposes, including improving gum health (periodontitis) and potentially aiding in conditions like Alzheimer's disease, atopic dermatitis (eczema), muscle fatigue, muscle strength, obesity, osteoarthritis, and schizophrenia. However, more research is needed to establish its effectiveness for these uses.
Drugs that interact with Mangosteen
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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