Noni Interactions Overview

Check For Interactions With Noni

Noni

Also known as
  • Morinda citrifolia
  • Ba Ji Tian
  • Bois Douleur
  • Canarywood
  • Cheese Fruit
  • Hawaiian Noni
  • Hog Apple
  • Indian Mulberry
  • Indian Noni
  • Luoling
  • Mengkudu
  • Morinda
  • Mulberry
  • Nhau
  • Noni Juice
  • Nono
  • Nonu
  • Rotten Cheese Fruit
  • Ura
  • Wild Pine
Noni Noni (Morinda citrifolia) is a tropical fruit that is native to Southeast Asia and the Pacific Islands. It is also known by a variety of other names, including Indian mulberry, beach mulberry, and cheese fruit. Noni fruit is typically not eaten fresh due to its strong flavor and smell. Regardless, many parts of the plant, including the roots, fruit, stem, bark, leaves, and flowers are used to make juice, supplements, and other products. Noni has a long history of use in traditional medicine. Some studies have suggested that noni may have potential health benefits, including the ability to reduce inflammation, improve immune function, and lower blood pressure. It is also thought to have antioxidant and anti-tumor effects.
There are 515 drugs known to interact with Noni

Additional Details

Is Noni Safe? Are There Any Warnings?

Caution is advised with Noni, a small evergreen tree found in the Pacific Islands and Southeast Asia. While it's generally considered safe when used orally and appropriately, the FDA has issued warnings to manufacturers about unverified medical claims. Some reports link certain Noni products to increased liver enzymes, so caution is advised, and more research is needed.

How Does Noni Work? What Is the Mechanism of Action?

Noni, utilized for centuries in traditional medicine, contains various components like potassium, vitamins, and anthraquinones. It exhibits diverse effects, such as analgesic, anthelmintic, antibacterial, antihypertensive, anti-inflammatory, and antioxidant properties. Some compounds in Noni may also have potential anticancer and antiviral effects. The mechanism involves complex interactions with enzymes, immune cells, and biochemical pathways.

Pharmacokinetics

When consumed, Noni is absorbed quickly, with components like scopoletin detected in the blood. It is distributed in various tissues and eliminated, with a half-life of about four hours. Human studies show the presence of scopoletin in urine after Noni use, indicating systemic absorption and excretion.

Interaction Overview

Noni may interact with drugs like ACE inhibitors, ARBs, antihypertensive medications, hepatotoxic drugs, phenytoin, potassium-sparing diuretics, ranitidine, and warfarin. Caution is advised due to potential effects on potassium levels, liver function, and drug efficacy.

Common Side Effects to Watch For

Generally well-tolerated, Noni may cause abdominal discomfort and nausea when taken orally. Rare but serious side effects include hepatotoxicity, especially with specific Noni juice brands. However, comprehensive studies on adverse effects are lacking.

Are Supplements Standardized?

Research often involves Tahitian Noni Juice, containing 89% pureed Noni in grapefruit and blackberry juices. Other formulations include dehydrated Noni fruit capsules and topical ointments with Noni stem extract. Standardization practices vary, and product purity may impact effectiveness.

What Is Noni Typically Used For?

Noni has been explored for various conditions, including pain relief, antiparasitic effects, blood pressure management, anti-inflammatory properties, and potential benefits in cancer, diabetes, and cardiovascular health. However, conclusive evidence supporting these uses is currently insufficient, and more research is needed for accurate assessments.

Drugs that interact with Noni

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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