Quercetin Interactions Overview

Check For Interactions With Quercetin

Quercetin

Also known as
  • 7-Pentahydroxyflavone
  • Bioflavonoid
  • Bioflavonoid Complex
  • Bioflavonoid Concentrate
  • Bioflavonoid Extract
  • Bioflavonoïde
  • Bioflavonoïde de Citron
  • Bioflavonoïdes de Citron
  • Citrus Bioflavones
  • Citrus Bioflavonoid
  • Citrus Bioflavonoids
  • Citrus Flavones
Quercetin Quercetin is a type of flavonoid, which is a class of compounds found in a wide variety of plants and foods. It is purported to have a number of health benefits such as anti-inflammatory, antioxidant, and immune-boosting effects. Studies suggest it may also help to reduce the risk of certain chronic diseases, such as heart disease. In addition, quercetin may have anti-allergic properties and may be helpful in the treatment of allergies and asthma. It is a popular dietary supplement worldwide and is often included in products that contain antioxidants or various vitamins/minerals. Its wide range of potential health benefits mean that it could potentiate the effects of other drugs (e.g., anti-hypertensives), which is why there are an abundant number of potential interactions listed for quercetin.
There are 1133 drugs known to interact with Quercetin

Additional Details

Is Quercetin Safe? Are There Any Warnings?

Quercetin is generally considered safe for short-term oral and intravenous use when taken in appropriate doses. Oral doses of up to 1 gram per day for up to 12 weeks have been used safely. Intravenous use in doses less than 945 mg/m2 has also been deemed safe. However, higher intravenous doses may cause nephrotoxicity, a condition that affects the kidneys. It is important to note that there is insufficient reliable information available about the safety of topical use of quercetin. Due to the lack of reliable data, it is recommended to avoid using quercetin during pregnancy and lactation. Overall, quercetin is well tolerated when used within appropriate dosage limits, but more comprehensive safety evaluations are needed.

How Is Quercetin Thought To Work?

Quercetin is a flavonoid that exerts various biological effects in the body. It is known for its antioxidant and anti-inflammatory properties, which contribute to its potential health benefits. Quercetin works by scavenging harmful free radicals and reducing oxidative stress, which can damage cells and contribute to various diseases. It also inhibits the activity of certain enzymes involved in inflammation, thereby reducing inflammation in the body. Additionally, quercetin has been found to modulate the expression of genes and proteins involved in cell signaling pathways, which may contribute to its therapeutic effects. Its ability to interact with different molecular targets in the body makes quercetin a versatile compound with potential applications in various health conditions.

Pharmacokinetics

Quercetin is absorbed from the gastrointestinal tract after oral administration. Its absorption can be enhanced by the presence of certain nutrients, such as vitamin C. Once absorbed, quercetin undergoes metabolism in the liver, where it is converted into various metabolites. These metabolites are then distributed throughout the body and can be detected in various tissues and organs. Quercetin is eliminated from the body primarily through the bile and feces. The exact pharmacokinetic profile of quercetin, including its absorption, distribution, metabolism, and excretion, can vary depending on factors such as the dose, formulation, and individual characteristics of the person consuming it.

Interaction Overview (See Below For Full List)

Quercetin may interact with certain medications, and caution should be exercised when using it in combination with specific drugs. Some notable interactions include: Antidiabetes drugs: Quercetin might increase the risk of hypoglycemia when used with antidiabetes medications. Antihypertensive drugs: Combining quercetin with antihypertensive drugs may increase the risk of hypotension. Cyclosporine: Concomitant use of quercetin and cyclosporine may increase the levels and adverse effects of cyclosporine. Cytochrome P450 substrates: Quercetin might affect the levels and adverse effects of certain drugs metabolized by cytochrome P450 enzymes. Other interactions with specific drugs are also possible and should be considered.

Common Side Effects To Watch For

Quercetin is generally well tolerated when used in appropriate doses. Common side effects are rare but may include gastrointestinal discomfort, such as nausea, vomiting, or diarrhea. However, these side effects are usually mild and temporary. It is important to note that a thorough evaluation of safety outcomes for quercetin has not been conducted, and more research is needed to fully understand its potential side effects.

Are Supplements Standardized?

Quercetin can be found in different food items. A review of foods rich in quercetin indicates that 750 mL of red wine contains approximately 14 mg of quercetin, while 50 grams of yellow onions provide a range of 5-26 mg of quercetin. Similarly, 375 mL of black tea contains about 2-14 mg of quercetin, and one liter of either black currant or apple juice contains around 6.4 mg of quercetin.

Drugs that interact with Quercetin

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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