Acacia Fiber Ingredients & Drug Interactions
by NOW
What is this page for?
First and foremost: checking Acacia Fiber against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Acacia Fiber is a dietary supplement by NOW with 4 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,025 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Acacia Gum Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Acacia Fiber by NOW
Ask about any prescription or over-the-counter medication and we check it for interactions with Acacia Fiber by NOW — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Acacia Fiber by NOW
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains just one active ingredient: acacia gum powder, a soluble fiber sourced from the acacia tree. It's used in foods and supplements as a thickener and fiber source.
Does it work?
Strong evidence
The evidence for acacia gum isn't established in our data for the conditions tested — metabolic syndrome, kidney failure, sickle cell disease, obesity, gingivitis, and peristomal lesions all show insufficient reliable evidence to rate it as effective.
How safe is it?
Well-documented data
Acacia gum is generally recognized as safe as a food additive. At supplemental doses, though, it hasn't been well studied, so it's worth checking with your doctor before you start.
Side effects in the digestive tract are common when you first take it. Most people report abdominal bloating, flatulence, mild diarrhea, nausea, and sometimes vomiting — one study found these in a significant number of participants — but they often settle down within 2 weeks of continued use.
There isn't enough information on the safety of supplement doses while breastfeeding; talk to your doctor or pharmacist for personalized guidance.
Meds to double-check
Moderate interaction found
Separate this supplement from amoxicillin and other oral antibiotics by at least 2 hours — acacia gum can reduce their absorption and make them less effective. More broadly, avoid taking any oral medication within 30 minutes before or 2 hours after your acacia fiber dose to protect drug absorption.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
NOW Acacia Fiber is a plain soluble fiber supplement with no proven benefits in our data for the conditions studied. It does interact with several medications, especially antibiotics.
If you take any oral drugs, check them against this product's interaction tool before you start, and space doses apart by at least 2 hours. A pharmacist can help you time it right.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 24, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Acacia Fiber, straight from the product label.
| Brand | NOW |
|---|---|
| Barcode (UPC) | 733739059062 |
| Net contents | 12 oz.; 340 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Dec 24, 2013 |
| DSLD ID | 28630 |
| Product type | Botanical With Nutrients |
| Supplement form | Powder |
| Dietary claims / uses | Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Acacia Fiber by NOW, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 5 {Calories} | -- |
| Total Carbohydrates | 6 Gram(s) | 2% |
| Sugar | 0 Gram(s) | -- |
| Dietary Fiber | 6 Gram(s) | 24% |
| Protein | 0 Gram(s) | -- |
| Total Fat | 0 Gram(s) | -- |
| Acacia Gum Powder | 6.5 Gram(s) | -- |
Other ingredients: None
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
SUGGESTED USAGE: As a dietary supplement, mix 1 level tablespoon per day into at least 8 oz. of water or juice. Due to fiber content, be sure to drink plenty of additional fluids throughout the day. For those sensitive to fiber, start with 1 teaspoon daily, and gradually increase to 1 tablespoon. Consider taking these other NOW(R) products: Gr8-Dophilus(TM), Triphala and Detox Support(TM).
Brand IP Statement(s)
NOW(R) Acacia Fiber Powder is a natural, pure, soluble dietary fiber produced from the gum of the Acacia tree.
General
CODE 5906 V1
General Statements
INTESTINAL HEALTH*
Pure Powder - Highly Soluble, Mixes Instantly - Gentle Fiber
For more product information visit www.nowfoods.com/5906
100% Pure.
This product is sold by weight not volume.
Please Recycle.
Scientific studies have shown that as part of the diet, soluble fiber can help to encourage intestinal regularity. Acacia Powder is also known to be an excellent prebiotic, as it supports healthy gut flora. Because it actually slows fermentation and decreases gas and bloating, Acacia Powder is well tolerated.*
FDA Statement of Identity
A Dietary Supplement
Formulation
Vegetarian/Vegan
Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.
NOW(R) Acacia Fiber Powder can be used daily and contains no GI irritants or stimulants.
Seals/Symbols
GMP QUALITY ASSURED
Precautions
Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Storage
Store in a cool, dry place after opening.
FDA Disclaimer Statement
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Acacia Fiber by NOW label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Acacia Fiber by NOW
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size0.33 Tbsp Dosage formPowder Servings per container52 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sugar
Dietary Fiber
Interacts with2,025 drugs
Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...
Dietary Fiber monograph & interactionsProtein
Acacia Gum Powder
Interacts with2,022 drugs
Gum arabic is a soluble dietary fiber from the acacia tree that is widely used as a safe food additive and is sometimes taken as a supplement for dige...
Acacia Gum Powder monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
Acacia Fiber by NOW Drug Interactions
HelloPharmacist Interaction Report
NOW Acacia Fiber is a single-ingredient powder made from acacia gum, and it does interact with some medications — most notably antibiotics like amoxicillin.
Gum arabic can reduce how much amoxicillin your body absorbs, which may make the antibiotic less effective. A small study in healthy volunteers found that taking them together significantly lowered amoxicillin absorption; separate your doses by at least 2 hours if you take this supplement.
Read the full breakdown — every affected drug type, severity by severity
Beyond amoxicillin, acacia gum can theoretically alter how your body absorbs oral drugs more broadly due to its fiber content. It may improve absorption of certain water-insoluble drugs but reduce it for others like polar medications.
To be safe, take any oral medication 30 minutes before or 2 hours after your acacia fiber dose. Altogether, these interactions span 2,003 individual medications.
If you take any prescription oral medications — especially antibiotics — run them through the interaction checker below before you start this supplement.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Acacia Fiber?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Acacia Fiber interact with 2,025 drugs. Click any drug to see the details.
2 of the 4 ingredients in Acacia Fiber interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Acacia Gum Powder
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Caffeine, Pyrilamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Chlorpheniramine, Phenylephrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, ChlorzoxazoneAcetazone Forte, Extra Strength Tylenol Aches & Strains, Parafon Forte
How Acetaminophen, Chlorzoxazone interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Chlorzoxazone interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorzoxazone interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Chlorzoxazone, Codeine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Codeine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Codeine, Doxylamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Codeine, Methocarbamol interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, Dexbrompheniramine, PseudoephedrineSinadrin Plus
How Acetaminophen, Dexbrompheniramine, Pseudoephedrine interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Dextromethorphan interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
How Acetaminophen, Dextromethorphan, Pseudoephedrine interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine
How Acetaminophen, Dichloralantipyrine, Isometheptene interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Dichloralantipyrine, Isometheptene interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dichloralantipyrine, Isometheptene interactionAcetaminophen, Dichloralphenazone, IsomethepteneMidrin
How Acetaminophen, Dichloralphenazone, Isometheptene interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Dichloralphenazone, Isometheptene interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dichloralphenazone, Isometheptene interactionAcetaminophen, Dichlorophenazone, IsometheptaneIsocom
How Acetaminophen, Dichlorophenazone, Isometheptane interacts with Acacia Fiber — through 2 ingredients. Tap an ingredient for the detail:
Acacia Gum PowderOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Acacia Gum Powder + Acetaminophen, Dichlorophenazone, Isometheptane interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dichlorophenazone, Isometheptane interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Acacia Fiber with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Dietary Fiber
Carbamazepine (Tegretol)
Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.
Lithium
Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.
Metformin (Glucophage)
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.
Olanzapine (Zyprexa)
Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.
Digoxin (Lanoxin)
Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.
Ethinyl Estradiol
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.
Oral Drugs
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.
Acacia Gum Powder
Amoxicillin (Amoxil, Trimox)
Gum arabic can reduce the absorption of amoxicillin.
A small study in healthy volunteers shows that taking amoxicillin and gum arabic concurrently significantly reduces the absorption of amoxicillin. Separate doses of amoxicillin from gum arabic by at least 2 hours.
Oral Drugs
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Gum arabic has been used as a suspending osmotic agent in drug formulations. It might improve bioavailability of water-insoluble drugs like naproxen, but reduce absorption of polar drugs like amoxicillin. To avoid changes in absorption, take gum arabic 30-60 minutes after oral medications.
Brand information
Manufacturer and brand details for Acacia Fiber, from the product label.
Acacia Fiber by NOW: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Acacia Fiber’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Black Psyllium
Interacts with 2,025 drugsBlack psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...
Read the full Black Psyllium monograph → Herb & supplement monographGum Arabic
Interacts with 2,022 drugsGum arabic is a soluble dietary fiber from the acacia tree that is widely used as a safe food additive and is sometimes taken as a supplement for digestive health and as a prebiotic. Early s...
Read the full Gum Arabic monograph →Sources & How We Checked
Acacia Fiber's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Black Psyllium 18 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
- Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
- Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
- Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
- Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
- Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
- Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
- Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
- Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
- Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
- Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
- Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
- Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
- Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
- Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed
Gum Arabic 8 references
- Jensen CD, Spiller GA, Gates JE, et al. The effect of acacia gum and a water-soluble dietary fiber mixture on blood lipids in humans. J Am Coll Nutr 1993;12:147-54. PubMed
- Eltayeb IB, Awad AI, Elderbi MA, Shadad SA. Effect of gum arabic on the absorption of a single oral dose of amoxicillin in healthy Sudanese volunteers. J Antimicrob Chemother 2004;54:577-8. PubMed
- Babiker R, Merghani TH, Elmusharaf K, et al. Effects of gum Arabic ingestion on body mass index and body fat percentage in healthy adult females: two-arm randomized, placebo controlled, double-blind trial. Nutr J 2012;11:111. PubMed
- Babiker R, Elmusharaf K, Keogh MB, Banaga AS, Saeed AM. Metabolic effect of gum Arabic (Acacia senegal) in patients with type 2 diabetes mellitus (T2DM): randomized, placebo controlled double blind trial. Functional Foods in Health and Disease. 2017;7(3): DOI
- Beneke CE, Viljoen AM, Hamman JH. Polymeric plant-derived excipients in drug delivery. Molecules. 2009;14(7):2602-20. PubMed
- Ali NE, Kaddam LA, Alkarib SY, et al. Gum Arabic (Acacia Senegal) Augmented Total Antioxidant Capacity and Reduced C-Reactive Protein among Haemodialysis Patients in Phase II Trial. Int J Nephrol. 2020;2020:7214673.
- Mortensen A, Aguilar F, Crebelli R, et al. Re-evaluation of acacia gum (E 414) as a food additive. EFSA J. 2017;15(4):e04741. PubMed
- Larson R, Nelson C, Korczak R, et al. Acacia Gum Is Well Tolerated While Increasing Satiety and Lowering Peak Blood Glucose Response in Healthy Human Subjects. Nutrients 2021;13(2):618. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC