Advanced Digestive Enzymes Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Advanced Digestive Enzymes against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Advanced Digestive Enzymes is a dietary supplement by Totally Products with 3 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Advanced Digestive Enzymes by Totally Products
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains three digestive enzymes: amylase, protease, and lipase. These are the active ingredients—proteins your pancreas naturally makes to break down carbohydrates, proteins, and fats in food.
The capsule also includes inactive ingredients: microcrystalline cellulose, gelatin, magnesium stearate, and silicon dioxide, which help hold the capsule together and keep the powder moving smoothly.
Does it work?
Not established
The evidence for these enzymes in digestive health isn't well established in our data. Lipase—one of the three actives—has been studied for inflammatory bowel disease (IBD) and dyspepsia (indigestion), but the evidence is rated insufficient to say whether it works.
That doesn't mean it's ineffective; it means the studies we have don't prove it yet. Talk with your pharmacist about whether a digestive enzyme might fit your situation.
How safe is it?
Well-documented data
All three ingredients are generally well tolerated in adults, though protease and lipase may occasionally cause digestive upset. Protease rarely causes allergic reactions; some occupational reports link airborne protease to allergic rhinitis (nasal allergies) or asthma, but that's from inhaled exposure in industrial settings, not from taking a capsule by mouth.
For pregnancy, protease safety has not been established—it's best avoided unless prescribed. Lipase has little safety data in pregnancy; use only if advised by your doctor.
During breastfeeding, there isn't enough data on either protease or lipase to recommend them without medical advice. Lipase should be used cautiously in people with serious digestive conditions; check with your doctor first.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. Still, it's smart to use the medication checker below with any prescriptions you're taking, just to be thorough.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.
This product may be worth trying if you have general digestive troubles and want enzyme support, though the evidence for how well it works isn't solid yet. If you're pregnant or breastfeeding, or if you have a serious digestive disease, talk to your doctor or pharmacist before starting.
And do run any prescription medications you take through the checker on this page.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Advanced Digestive Enzymes, straight from the product label.
| Brand | Totally Products |
|---|---|
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 18, 2023 |
| DSLD ID | 294221 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Advanced Digestive Enzymes by Totally Products, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Pancreatin | 325 mg | -- |
Other ingredients: Microcrystalline Cellulose, Gelatin, Magnesium Stearate, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
How to use: 1 to 2 capsules before each meal or as directed by a healthcare professional. Do not exceed 6 capsules daily.
Precautions
Caution: This product is manufactured and packaged in a facility which may also process milk, soy, wheat, egg, peanuts, fish and crustacean shellfish.
Do not exceed recommended dose.
Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
Keep out of the reach of children.
Do not use if safety seal is damaged or missing.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
Please recycle.
Seals/Symbols
Made in USA GMP Good Manufacturing Practice Consistent Quality
Formulation
GMO Free
Supports healthy digestion Supports digestion of fats, carbs, protein & more All natural Optimizes nutrient availability
Non-GMO Formula!
Formula
Quadruple strength pancreatin (4X)
FDA Statement of Identity
Dietary Supplement
Storage
Store in a cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Advanced Digestive Enzymes by Totally Products label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Advanced Digestive Enzymes by Totally Products
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: Microcrystalline Cellulose, Gelatin, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Advanced Digestive Enzymes by Totally Products Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Advanced Digestive Enzymes. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Advanced Digestive Enzymes, from the product label.
Totally Products
See all Totally Products products- Name
- Totally Products LLC
- Street Address
- 1835 E Hallandale Bch Blvd suite 425
- City
- Hallandale
- State
- FL
- ZipCode
- 33009
- Phone Number
- 800-924-0710
Advanced Digestive Enzymes by Totally Products: Common Questions
Does Advanced Digestive Enzymes by Totally Products interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What exactly do these enzymes do?
Can I take this if I'm pregnant?
What about while breastfeeding?
Does this product have a lot of fillers?
Could this cause any side effects?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Advanced Digestive Enzymes is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Advanced Digestive Enzymes’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph →Sources & How We Checked
Advanced Digestive Enzymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC