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Dietary supplement

Agmatine Sulfate 650 mg Ingredients & Drug Interactions

by Swanson

Agmatine Sulfate 650 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Agmatine Sulfate 650 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Agmatine Sulfate 650 mg is a dietary supplement by Swanson with 1 active ingredient. Its ingredients are commonly taken for pre- and post-workout support, muscle pumps and exercise performance, cognitive support and mood.Based on those ingredients, 258 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Agmatine Sulfate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Agmatine Sulfate 650 mg by Swanson

Ask about any prescription or over-the-counter medication and we check it for interactions with Agmatine Sulfate 650 mg by Swanson — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Agmatine Sulfate 650 mg by Swanson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: agmatine sulfate 650 mg per capsule. Agmatine is a compound produced naturally in your body from the amino acid arginine.

The capsule also contains several inactive ingredients—hypromellose, rice bran, rice extract blend, and rice concentrate—which serve as fillers and capsule material.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Agmatine's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: promotes nitric oxide and blood circulation.
  • We looked for evidence on: Athletic performance, Muscle strength, Endothelial function, Vasodilation.
  • The closest evidence on file: Agmatine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Agmatine is rated "Insufficient Reliable Evidence To Rate" for Muscle strength.

The evidence for agmatine sulfate isn't established yet. The data we hold shows insufficient reliable evidence to rate its effectiveness for alcohol use disorder, Alzheimer disease, anxiety, athletic performance, autism spectrum disorder, and bipolar disorder.

If you're considering this supplement for any of those purposes, we'd recommend talking with your pharmacist or doctor about what the current research actually supports.

The evidence, ingredient by ingredient Agmatine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use of agmatine appears generally well tolerated. The most common side effects in clinical studies were diarrhea, indigestion (dyspepsia), and nausea—and they appeared within a few days of starting.

In one small study, mild-to-moderate diarrhea and nausea were reported in 3 out of 24 people taking 3.56 grams daily, and both resolved once they stopped. Long-term safety in humans hasn't been well studied, so use caution if you're thinking about taking this for an extended period.

The safety data during pregnancy and breastfeeding isn't sufficient, so it's best to avoid use in both situations—talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Agmatine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Agmatine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 258 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your blood pressure medications and diabetes medications before taking this product. Both carry a Moderate-severity risk of agmatine lowering your blood pressure or blood sugar too far.

Use the medication checker below to verify your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Agmatine sulfate is a single-ingredient supplement that's been shown to be generally well tolerated in the short term, though some people experience digestive side effects. It carries moderate-risk interactions with blood pressure and diabetes medications, so check your exact drugs before starting.

Long-term safety and effectiveness aren't well established, so a conversation with your pharmacist is a good idea.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Agmatine Sulfate 650 mg, straight from the product label.

Brand Swanson
Barcode (UPC) 087614430027
Net contents 60 Veggie Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2019
DSLD ID 193318
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Agmatine Sulfate 650 mg by Swanson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
UPC/BARCODE
087614430027
IngredientAmount% DV
Agmatine Sulfate650 mg--

Other ingredients: Hypromellose, Rice Bran, Rice extract Blend, Rice concentrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Promotes nitric oxide production Maintains healthy blood circulation Supports increased energy and enhanced mental and physical wellbeing Science-Backed Quality Since 1969

Cardiovascular Health and Energy

650 mg per capsule

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take one veggie capsule one to two times per day with water.

Precautions

Warning: For adults only.

Do not take this product if you are pregnant or nursing. Consult your healthcare provider before use if you are taking any prescription medications or have a medical condition.

Not intended for use by persons under the age of 18.

Keep out of reach of children.

Do not use if seal is broken.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General

SWRJ002 Rev 0 09 24 18

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Agmatine Sulfate 650 mg by Swanson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Agmatine Sulfate 650 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Agmatine Sulfate 650 mg by Swanson

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Amounts shown are per serving.

Agmatine Sulfate

Interacts with
258 drugs
650 mg per serving

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...

Agmatine Sulfate monograph & interactions

Other (inactive) ingredients: Hypromellose, Rice Bran, Rice extract Blend, Rice concentrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Agmatine Sulfate 650 mg by Swanson Drug Interactions

Want to check YOUR meds against Agmatine Sulfate 650 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
258Drugs
258 Moderate

Ingredients driving the most interactions

Agmatine Sulfate 258

Individual Drug Interactions

The ingredients in Agmatine Sulfate 650 mg interact with 258 drugs. Click any drug to see the details.

1 of the 1 ingredient in Agmatine Sulfate 650 mg interact with drugs. Each result below shows which ingredient is responsible. Agmatine Sulfate

Each ingredient & the kinds of drugs it affects

For each ingredient in Agmatine Sulfate 650 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Agmatine Sulfate2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine Sulfate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Agmatine Sulfate 650 mg, from the product label.

Swanson

See all Swanson products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
swanson.com
Pharmacist Counseling Corner

Agmatine Sulfate 650 mg by Swanson: Common Questions

Does Agmatine Sulfate 650 mg by Swanson interact with any medications?
Yes. Based on its ingredients, Agmatine Sulfate 650 mg has a known interaction with 258 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Agmatine Sulfate 650 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is agmatine, and what does it do in the body?
Agmatine is a compound your body naturally makes from the amino acid arginine. It's found in small amounts in foods and has been studied for various effects, though the evidence for most health claims is still limited.
Can I take this if I'm pregnant or breastfeeding?
The safety data isn't strong enough yet, so it's best to avoid agmatine during pregnancy and while breastfeeding. Talk with your doctor or pharmacist for guidance specific to your situation.
What side effects might I experience?
The most common are diarrhea, indigestion, and nausea. In one small study, these showed up within a couple of days and went away when people stopped taking it. Most people tolerate short-term use without trouble.
How long has agmatine been studied in humans?
Short-term studies show it's generally well tolerated, but long-term safety in humans hasn't been well researched. If you're planning to take it for weeks or months, that's worth discussing with your pharmacist.
Does this supplement actually work for any condition?
The evidence we hold doesn't establish effectiveness for the conditions it's typically marketed for—things like anxiety, mood, or athletic performance. The data is still being gathered.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Agmatine Sulfate 650 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Agmatine Sulfate 650 mg label
Go deeper

The Full Monographs Behind Agmatine Sulfate 650 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph →
Sources

Sources & How We Checked

Agmatine Sulfate 650 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Agmatine 3 references
  1. Piletz JE, Aricioglu F, Cheng JT, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today 2013;18(17-18):880-93. PubMed
  2. Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 201 PubMed
  3. Shopsin B. The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr 2013;25(2):113-8. PubMed

See these in context on the Agmatine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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