Major interaction on record — check this product against your medications before combining. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

ArthroMax Advanced With UC-II & AprèsFlex Ingredients & Drug Interactions

by Life Extension

ArthroMax Advanced With UC-II & AprèsFlex label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ArthroMax Advanced With UC-II & AprèsFlex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

ArthroMax Advanced With UC-II & AprèsFlex is a dietary supplement by Life Extension with 4 active ingredients. Its ingredients are commonly taken for bone health, joint and arthritis support, hormone (testosterone/estrogen) support.Based on those ingredients, 1,029 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are ApresFlex Indian Frankincense (Boswellia serrata) extract, Glucosamine Sulfate 2KCI. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against ArthroMax Advanced With UC-II & AprèsFlex by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with ArthroMax Advanced With UC-II & AprèsFlex by Life Extension — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of ArthroMax Advanced With UC-II & AprèsFlex by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “UC-II standardized Cartilage” is listed as a grouped ingredient — the label gives one combined amount (40 mg) without saying how much of each component you get.

ArthroMax Advanced contains four active ingredients. Glucosamine sulfate 2KCI is included to support joint health and cartilage structure.

Boron is a mineral that plays a role in bone and joint function. The product also contains UC-II standardized cartilage (a type of collagen) and ApresFlex, an extract from Indian frankincense (Boswellia serrata), both used traditionally for joint support.

Additionally, the capsules contain inactive ingredients including vegetable cellulose, potassium chloride, microcrystalline cellulose, vegetable stearate, and silica.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: joint health and cartilage support.
  • We looked for evidence on: Joint pain, Knee pain, Osteoarthritis, Back pain, Rheumatoid arthritis (RA), Kashin-Beck Disease — and 3 related terms.
  • The strongest evidence on file: Glucosamine is rated "Likely Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Boswellia Serrata is rated "Possibly Effective" for Osteoarthritis.
  • Also on file: Boswellia Serrata is rated "Insufficient Reliable Evidence To Rate" for Rheumatoid arthritis (RA), Knee pain.

Glucosamine sulfate is likely effective for osteoarthritis, meaning research supports its use for joint pain and function in that condition. Its effectiveness for other uses—aging skin, back pain, cancer, and fatty liver disease—lacks sufficient reliable evidence in our data.

Boron is likely effective for treating boron deficiency and possibly effective for vaginal yeast infections and radiation-related skin damage. Evidence on athletic performance suggests boron is possibly ineffective for that purpose.

The evidence supporting UC-II cartilage and ApresFlex frankincense for arthritis is not established in the data we hold.

The evidence, ingredient by ingredient Boron Glucosamine Boswellia Serrata

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glucosamine is generally well tolerated by most adults when taken by mouth. The most common side effects are mild and digestive—bloating, constipation, cramps, diarrhea, heartburn, and nausea.

Rare reports of allergic reactions exist, ranging from mild (itching, hives) to severe (difficulty breathing, low blood pressure), and a very small number of anaphylaxis cases have been documented. There have also been rare reports of asthma flare-ups with glucosamine-chondroitin products.

Boron is generally safe in small amounts from food and low-dose supplements, but high doses can be toxic. The most common side effects from oral boron at normal doses are loss of appetite, skin inflammation, and indigestion.

The safety data advises against boron supplements in pregnancy and while breastfeeding due to potential harm to the fetus and insufficient safety information for nursing mothers. For glucosamine, there is not enough safety information to recommend it during pregnancy, and not enough is known about breastfeeding safety either—talk with your doctor or pharmacist if you are or plan to become pregnant or nurse.

Side effects, ingredient by ingredient Boron Glucosamine Boswellia Serrata

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Boswellia Serrata, Glucosamine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,030 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take warfarin or any other blood thinner—glucosamine may increase bleeding risk. If you're on chemotherapy (particularly topoisomerase II inhibitors like etoposide or doxorubicin), diabetes medications, or regular acetaminophen for pain, confirm it's okay to add this product to your routine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is used for osteoarthritis and general joint support, and glucosamine sulfate has evidence backing that use. If you take warfarin or any blood thinner, are on chemotherapy, manage diabetes with medication, or are pregnant or breastfeeding, you should talk with your doctor or pharmacist before starting it.

Run your complete medication list through the checker on this page to be sure.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ArthroMax Advanced With UC-II & AprèsFlex, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870161868
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD May 22, 2016
DSLD ID 59533
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ArthroMax Advanced With UC-II & AprèsFlex by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
737870161868
IngredientAmount% DV
Total Collagen10 mg--
Boron1.5 mg--
Glucosamine Sulfate 2KCI1500 mg--
ApresFlex Indian Frankincense (Boswellia serrata) extract20 mg--
UC-II standardized Cartilage40 mg--

Other ingredients: Vegetable Cellulose, Potassium Chloride, Microcrystalline Cellulose, Vegetable Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Scan for product info

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Suggested/Recommended/Usage/Directions

Read the entire label and follow directions carefully prior to use. DIRECTIONS: Take two (2) capsules daily with food, or as recommended by a healthcare practitioner.

Formula

^3-O-acetyl-11-keto-{Beta}-boswellic acid

Clinical Strength Ingredients Convenient Dose

Precautions

WARNINGS: - KEEP OUT OF REACH OF CHILDREN.

- DO NOT EXCEED RECOMMENDED DOSE. - Do not purchase if outer seal is broken or damaged.

- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Brand IP Statement(s)

UC-II is a registered trademark of InterHealth N.I. (U.S. Patents 7,846,487, 7,083,820 and EPO Patent EP1435906B1; Canadian Patent CA 2459981C; and Japanese Patent JP 4800574B2).

ApresFlex is a registered trademark of Laila Nutraceuticals exclusively licensed to PL Thomas - Laila NUTRA LLC. U.S. Patent No. 8,551,496 and other patents pending. FruitX B and OsteoBoron are registered trademarks of VDF FutureCeuticals, Inc. U.S. Patent No. 5,962,049.

General

Q01618I

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store tightly closed in a cool, dry place.

Formulation

Non-GMO

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ArthroMax Advanced With UC-II & AprèsFlex by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ArthroMax Advanced With UC-II & AprèsFlex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ArthroMax Advanced With UC-II & AprèsFlex by Life Extension

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Boron

No known
interactions
1.5 mg per serving Form: Calcium Fructoborate

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence f...

Boron monograph & interactions

Glucosamine Sulfate 2KCI

Interacts with
170 drugs
1500 mg per serving Form: Corn

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of...

Glucosamine Sulfate 2KCI monograph & interactions

ApresFlex Indian Frankincense (Boswellia serrata) extract

Interacts with
952 drugs
20 mg per serving Form: 3-O-Acetyl-11-Keto-{Beta}-Boswellic Acid

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoart...

ApresFlex Indian Frankincense (Boswellia serrata) extract monograph & interactions

UC-II standardized Cartilage

40 mg per serving
  • › Total Collagen

Other (inactive) ingredients: Vegetable Cellulose, Potassium Chloride, Microcrystalline Cellulose, Vegetable Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

ArthroMax Advanced With UC-II & AprèsFlex by Life Extension Drug Interactions

Want to check YOUR meds against ArthroMax Advanced With UC-II & AprèsFlex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,029Drugs
2 Major 958 Moderate 69 Minor

Ingredients driving the most interactions

ApresFlex Indian Frankincense (Boswellia serrata) extract 952
Glucosamine Sulfate 2KCI 170

Individual Drug Interactions

The ingredients in ArthroMax Advanced With UC-II & AprèsFlex interact with 1,029 drugs. Click any drug to see the details.

2 of the 4 ingredients in ArthroMax Advanced With UC-II & AprèsFlex interact with drugs. Each result below shows which ingredient is responsible. ApresFlex Indian Frankincense (Boswellia serrata) extract Glucosamine Sulfate 2KCI

Each ingredient & the kinds of drugs it affects

For each ingredient in ArthroMax Advanced With UC-II & AprèsFlex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

ApresFlex Indian Frankincense (Boswellia serrata) extract6 drug types · 952 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C19 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C9 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2D6 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Some in vitro research suggests that Boswellia serrata extracts might inhibit mediators of autoimmune disorders such as leukotrienes and reduce production of antibodies and cell-mediated immunity. However, other in vitro research suggests that, when coupled with calcium ions, boswellic acids containing the keto group have immunostimulant properties within specific cell signaling pathways.

Likelihood Possible Evidence D
ApresFlex Indian Frankincense (Boswellia serrata) extract full monograph & interactions

Glucosamine Sulfate 2KCI4 drug types · 170 drugs

Warfarin (Coumadin)

Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in international normalized ratio (INR) in patients previously stabilized on warfarin. In one case, the increase in INR occurred only after tripling the dose of a glucosamine/chondroitin supplement from 500 mg/400 mg daily to 1500/1200 mg daily. Additionally, 20 voluntary case reports to the U.S. Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone to increased INR in patients taking warfarin. The mechanism of this interaction is unclear. Glucosamine is a small component of heparin, but is not thought to have anticoagulant activity; however, animal research suggests that it might have antiplatelet activity.

Likelihood Probable Evidence D
Topoisomerase Ii Inhibitors

Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
In vitro research suggests that glucosamine might induce resistance to etoposide (VP16, VePesid) and doxorubicin (Adriamycin) by reducing inhibition of topoisomerase II, an enzyme required for DNA replication in tumor cells. This effect has not been reported in humans.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Acetaminophen might interfere with the activity of glucosamine sulfate by interacting with the sulfate portion.
Anecdotal reports suggest that adding glucosamine to an acetaminophen regimen might decrease pain control in patients with osteoarthritis. Some research suggests that the sulfate portion of glucosamine sulfate might contribute to its effect in osteoarthritis. Since acetaminophen metabolism requires sulfur and reduces serum sulfate concentrations, acetaminophen could theoretically interfere with the action of glucosamine sulfate. Conversely, the administration of sulfate could theoretically decrease the effectiveness of acetaminophen in sulfate-deficient people by increasing its clearance.

Likelihood Possible Evidence B
Antidiabetes Drugs

Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.
In vitro and animal research has suggested that glucosamine might increase insulin resistance or decrease insulin production. This has raised concerns that taking glucosamine might worsen diabetes and decrease the effectiveness of diabetes drugs. However, clinical research suggests that glucosamine does not have adverse effects on blood glucose or glycated hemoglobin (HbA1C) in healthy, obese, or type 2 diabetes patients.

Likelihood Unlikely Evidence B
Glucosamine Sulfate 2KCI full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ArthroMax Advanced With UC-II & AprèsFlex, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

ArthroMax Advanced With UC-II & AprèsFlex by Life Extension: Common Questions

Does ArthroMax Advanced With UC-II & AprèsFlex by Life Extension interact with any medications?
Yes. Based on its ingredients, ArthroMax Advanced With UC-II & AprèsFlex has a known interaction with 1,029 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ArthroMax Advanced With UC-II & AprèsFlex contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is glucosamine sulfate, and why is it in this product?
Glucosamine sulfate is a compound that supports cartilage structure and is likely effective for osteoarthritis pain and joint function. It's one of the main active ingredients in ArthroMax.
Can I take this if I'm on warfarin or another blood thinner?
Glucosamine in this product may increase how much warfarin thins your blood and raise your risk of bruising and bleeding. Talk with your doctor or pharmacist before starting—they can monitor you if it's right for you.
What are the most common side effects?
From glucosamine, the most common are digestive: bloating, constipation, diarrhea, heartburn, and nausea. Most people tolerate it well. Boron at the dose in this product is generally well tolerated, though at very high doses it can cause loss of appetite or skin irritation.
Is this safe during pregnancy or breastfeeding?
There isn't enough safety information on glucosamine to recommend it during pregnancy or while breastfeeding. Boron supplements should be avoided in pregnancy and during nursing. Talk with your doctor or pharmacist about whether this product is right for you.
Does glucosamine work for back pain or other joint problems besides osteoarthritis?
Glucosamine is likely effective for osteoarthritis. For back pain and other uses, the evidence in our data is insufficient—we don't have enough reliable research to say one way or the other.
Can I take this with acetaminophen (Tylenol)?
Acetaminophen may slightly reduce how well glucosamine works for pain relief. If you regularly take acetaminophen, mention it to your doctor or pharmacist when considering this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if ArthroMax Advanced With UC-II & AprèsFlex is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ArthroMax Advanced With UC-II & AprèsFlex label
Go deeper

The Full Monographs Behind ArthroMax Advanced With UC-II & AprèsFlex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Boron

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence for most of these uses is limited or prel...

Read the full Boron monograph → Herb & supplement monograph

Glucosamine

Interacts with 170 drugs

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of the knee. The evidence is mixed, with so...

Read the full Glucosamine monograph → Herb & supplement monograph

Boswellia Serrata

Interacts with 952 drugs

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidenc...

Read the full Boswellia Serrata monograph →
Sources

Sources & How We Checked

ArthroMax Advanced With UC-II & AprèsFlex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 80 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boron 6 references
  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Thai L, Hart LL. Boric acid vaginal suppositories. Ann Pharmacother 1993;27:1355-7.
  4. Acs N, Banhidy F, Puho E, Czeizel AE. Teratogenic effects of vaginal boric acid treatment during pregnancy. Int J Gynaecol Obstet 2006;93:55-6. PubMed
  5. Garabrant, D. H., Bernstein, L., Peters, J. M., and Smith, T. J. Respiratory and eye irritation from boron oxide and boric acid dusts. J Occup Med 1984;26(8):584-586. PubMed
  6. Hjelm C, Harari F, Vahter M. Pre- and postnatal environmental boron exposure and infant growth: results from a mother-child cohort in northern Argentina. Environ Res 2019;171:60-8. PubMed

See these in context on the Boron monograph →

Glucosamine 58 references
  1. Adams ME. Hype about glucosamine. Lancet 1999;354:353-4. PubMed
  2. Balkan B, Dunning BE. Glucosamine inhibits glucokinase in vitro and produces a glucose-specific impairment of in vivo insulin secretion in rats. Diabetes 1994;43:1173-9. PubMed
  3. Giaccari A, Morviducci L, Zorretta D, et al. In vivo effects of glucosamine on insulin secretion and insulin sensitivity in the rat: possible relevance to the maladaptive responses to chronic hyperglycaemia. Diabetologia 1995;38:518-24. PubMed
  4. Holmang A, Nilsson C, Niklasson M, et al. Induction of insulin resistance by glucosamine reduces blood flow but not interstitial levels of either glucose or insulin. Diabetes 1999;48:106-11. PubMed
  5. Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol 1999;26:2423-30.
  6. Barclay TS, Tsourounis C, McCart GM. Glucosamine. Ann Pharmacother 1998;32:574-9.
  7. Shankar RR, Zhu JS, Baron AD. Glucosamine infusion in rats mimics the beta-cell dysfunction of non-insulin-dependent diabetes mellitus. Metabolism 1998;47:573-7.
  8. Almada A, Harvey P, Platt K. Effects of chronic oral glucosamine sulfate on fasting insulin resistance index (FIRI) in non-diabetic individuals. FASEB J 2000;14:A750.
  9. Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulfate on osteoarthritis progression: a randomised, placebo-controlled trial. Lancet 2001;357:251-6.
  10. Does glucosamine increase serum lipid levels and blood pressure? Pharmacist's Letter/Prescriber's Letter 2001;17(11):171115.
  11. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  12. Monauni T, Zenti MG, Cretti A, et al. Effects of glucosamine infusion on insulin secretion and insulin action in humans. Diabetes 2000;49:926-35. PubMed
  13. Pouwels MJ, Jacobs JR, Span PN, et al. Short-term glucosamine infusion does not affect insulin sensitivity in humans. J Clin Endocrinol Metab 2001;86:2099-103. DOI
  14. Yun J, Tomida A, Nagata K, Tsuruo T. Glucose-regulated stresses confer resistance to VP-16 in human cancer cells through a decreased expression of DNA topoisomerase II. Oncol Res 1995;7:583-90.
  15. Pavelka K, Gatterova J, Olejarova M, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: A 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med 2002;162:2113-23. PubMed
  16. Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam Pract 2002;15:481-4..
  17. Scroggie DA, Albright A, Harris MD. The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial. Arch Intern Med 2003; PubMed
  18. Hoffer LJ, Kaplan LN, Hamadeh MJ, et al. Sulfate could mediate the therapeutic effect of glucosamine sulfate. Metabolism 2001;50:767-70.. PubMed
  19. Yu JG, Boies SM, Olefsky JM. The effect of oral glucosamine sulfate on insulin sensitivity in human subjects. Diabetes Care 2003;26:1941-2. PubMed
  20. Danao-Camara T. Potential side effects of treatment with glucosamine and chondroitin. Arthritis Rheum 2000;43:2853. PubMed
  21. Guillaume MP, Peretz A. Possible association between glucosamine treatment and renal toxicity: comment on the letter by Danao-Camara. Arthritis Rheum 2001;44:2943-4. PubMed
  22. Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. Am J Health Syst Pharm 2004;61:306-307. PubMed
  23. Tannis AJ, Barban J, Conquer JA. Effect of glucosamine supplementation on fasting and non-fasting plasma glucose and serum insulin concentrations in healthy individuals. Osteoarthritis Cartilage 2004;12:506-11. PubMed
  24. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  25. Stumpf JL, Lin SW. Effect of glucosamine on glucose control. Ann Pharmacother 2006;40:694-8. PubMed
  26. Pham T, Cornea A, Blick KE, et al. Oral glucosamine in doses used to treat osteoarthritis worsens insulin resistance. Am J Med Sci 2007;333:333-9. PubMed
  27. Muniyappa R, Karne RJ, Hall G, et al. Oral glucosamine for 6 weeks at standard doses does not cause or worsen insulin resistance or endothelial dysfunction in lean or obese subjects. Diabetes 2006;55:3142-50. PubMed
  28. Knudsen J, Sokol GH. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: Case report and review of the literature and MedWatch database. Pharmacotherapy 2008;28:540-8. PubMed
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Boswellia Serrata 16 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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