Betaine Plus Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Betaine Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Betaine Plus is a dietary supplement by Douglas Laboratories with 2 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Betaine Plus by Douglas Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Betaine Plus contains 2 active ingredients: Pepsin and Betaine. Pepsin is a digestive enzyme (protease) that helps break down proteins in food.
Betaine is a compound involved in various metabolic processes in the body. The capsule also contains inactive ingredients — hydroxypropyl methylcellulose, vegetable stearate, silica, and microcrystalline cellulose — that serve as the capsule shell and flow agents.
Does it work?
Couldn't assess
We don't have effectiveness data on file for either Pepsin or Betaine in this product. The facts available to us don't establish a rating for how well they work for any particular purpose.
If you're considering this product for a specific health goal, your doctor or pharmacist can give you the best guidance on whether the evidence supports its use.
How safe is it?
Well-documented data
Pepsin is generally well tolerated in most adults, though some people report digestive upset or allergic reactions. In rare cases, occupational exposure to airborne pepsin has triggered allergic rhinitis or asthma — a concern mainly in workplace settings, not typical use of a supplement.
During pregnancy, safety hasn't been established, so it's best avoided unless your doctor prescribes it. During breastfeeding, there's little safety data, so medical advice is needed before use.
We have no safety data on file for Betaine.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredient we could check. We hold no interaction data for Betaine, so use the search tool on this page to verify your specific medications, and confirm with your doctor or pharmacist before you start.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. No medication interactions are currently documented, and safety information is well characterized.
Betaine Plus may be worth considering if your doctor or pharmacist recommends it for digestive enzyme or betaine supplementation. Because we couldn't check Betaine for interactions and safety data is incomplete, talk with your own healthcare provider before starting, especially if you're pregnant, breastfeeding, or taking any medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Betaine Plus, straight from the product label.
| Brand | Douglas Laboratories |
|---|---|
| Barcode (UPC) | 310539017715 |
| Net contents | 250 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 25, 2021 |
| DSLD ID | 244604 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Betaine Plus by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Pepsin | 140 mg | -- |
| Betaine | 496 mg | -- |
Other ingredients: Hydroxypropyl Methylcellulose, Vegetable Stearate, Silica, Microcrystalline Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Usage: As a dietary supplement, adults take 1 capsule with each meal or as directed by your health professional.
Precautions
Warning: If you are pregnant, nursing, have any health condition or taking any medication, consult your health professional before using this product.
Discontinue immediately if a burning sensation occurs. Not recommended for people with ulcers.
Keep out of the reach of children.
Use only if safety seal is intact.
Storage
Store in a cool dry place.
Formulation
Gluten-free, Non-GMO
Healthy digestive function
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
Scan to learn about our manufacturing excellence Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Betaine Plus by Douglas Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Betaine Plus by Douglas Laboratories
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container250 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Pepsin
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
Pepsin monograph & interactionsBetaine
Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Vegetable Stearate, Silica, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.
Betaine Plus by Douglas Laboratories Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Betaine Plus. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Betaine Plus, from the product label.
Douglas Laboratories
See all Douglas Laboratories products- Name
- Douglas Laboratories
- Street Address
- 600 Boyce Road
- City
- Pittsburgh
- State
- PA
- ZipCode
- 15205
- Phone Number
- 1.800.245.4440
- Web Address
- www.douglaslabs.com
Betaine Plus by Douglas Laboratories: Common Questions
Does Betaine Plus by Douglas Laboratories interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Betaine Plus while pregnant?
Is it safe to use while breastfeeding?
What is pepsin and what does it do?
Can pepsin cause allergic reactions?
Does this product have any fillers?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Betaine Plus is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Betaine Plus’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Betaine Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 3 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC