No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Betaine Powder Ingredients & Drug Interactions

by NOW Sports

Betaine Powder label
See full label image
Powder Category: Non-nutrient/non-botanical
No known interaction
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Betaine Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Betaine Powder is a dietary supplement by NOW Sports with 1 active ingredient. Its ingredients are commonly taken for high homocysteine levels, liver health (fatty liver), exercise performance and strength.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

Jump to a section

HelloPharmacist Scorecard of Betaine Powder by NOW Sports

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: betaine anhydrous. Betaine is a compound your body makes naturally, and it plays a role in metabolic processes and supporting overall cellular function.

The powder form lets you mix it into liquid or food.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Betaine Anhydrous's overall clinical evidence instead.

Strong

Strong clinical evidence supports Betaine Anhydrous for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Homocystinuria — rated "Effective" (Natural Medicines).
  • On file: Hyperhomocysteinemia — rated "Possibly Effective" (Natural Medicines).

Betaine anhydrous is effective for homocystinuria, a rare genetic condition that causes elevated homocysteine levels. It's possibly effective for hyperhomocysteinemia (elevated homocysteine in the blood).

For nonalcoholic fatty liver disease (NASH), colorectal polyp prevention, depression, and acid reflux, the evidence we have isn't strong enough to rate it either way.

The evidence, ingredient by ingredient Betaine Anhydrous

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Betaine anhydrous is generally well tolerated at studied doses. The most common side effects are body odor, diarrhea, nausea, vomiting, and general GI upset.

Cerebral edema (swelling in the brain) has been reported rarely. There isn't enough safety data to recommend this product during pregnancy unless a doctor advises it, and safety while breastfeeding isn't well established — talk with your doctor or pharmacist before use if you're nursing or pregnant.

Side effects, ingredient by ingredient Betaine Anhydrous

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the medications we could check. Still, run your medications through the tool on this page before you begin.

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.

This product makes sense if you've been diagnosed with homocystinuria or your doctor has suggested betaine for elevated homocysteine. If you're considering it for other reasons, the evidence isn't there yet.

Check with your pharmacist before starting, especially if you're pregnant, nursing, or have any GI sensitivity.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Betaine Powder, straight from the product label.

Brand NOW Sports
Barcode (UPC) 733739022264
Net contents 6 Ounce(s); 170 Gram(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 292044
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Betaine Powder by NOW Sports, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.6 Gram(s)
Maximum serving Sizes:
1.6 Gram(s)
Servings per container
106
UPC/BARCODE
733739022264
IngredientAmount% DV
Betaine Anhydrous1.6 Gram(s)--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Mix 1/2 level teaspoon into water or your favorite beverage twice daily.

Formula

Betaine (trimethylglycine) is a modified amino acid that normally participates as a cofactor in many reactions essential for normal cell function, including the synthesis of creatine, carnitine, and epinephrine, as well as the detoxification of homocysteine. Betaine also helps to preserve cell volume and function during the stress of intense exercise. Clinical studies show that Betaine may help to promote endurance and optimize muscle output and performance during exercise. Betaine may also help to support a healthy body composition when used along with a healthy diet and exercise program.

Pure powder

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: for adults only.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out reach of children.

Do not eat freshness packets enclosed.

Packaged and quality tested in the USA.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, tree nut or sesame ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Seals/Symbols

Quality GMP Assured

Formulation

Endurance Enhances performance Maintains muscle

Steroid tested

Vegan

Non-gmo

Product of Finland.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, tree nut or sesame ingredients.

Natural color variation may occur in this product.

FDA Statement of Identity

A Dietary Supplement

General Statements

This product is sold by weight not volume.

Storage

Store in a cool, dry, dark place after opening.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Betaine Powder by NOW Sports label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Betaine Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Betaine Powder by NOW Sports

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1.6 Gram(s) Dosage formPowder Servings per container106 Amounts shown are per serving.

Betaine Anhydrous

No known
interactions
1.6 Gram(s) per serving

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...

Betaine Anhydrous monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Betaine Powder by NOW Sports Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Betaine Powder. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Betaine Powder, from the product label.

NOW Sports

See all NOW Sports products
Name
NOW FOODS
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowsportsproducts.com
Pharmacist Counseling Corner

Betaine Powder by NOW Sports: Common Questions

Does Betaine Powder by NOW Sports interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Betaine Powder. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Betaine Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is betaine and what does it do?
Betaine is a naturally occurring compound in your body that's involved in metabolism and cellular function. It's most well-studied for helping people with homocystinuria, a rare genetic condition where homocysteine builds up in the blood and urine.
Can I take this if I'm pregnant?
There isn't enough safety data to know either way. Talk with your doctor before using this product during pregnancy — only take it if your doctor specifically advises it.
Can I take this while breastfeeding?
Safety while breastfeeding isn't well established. Because of that uncertainty, caution is advised — check with your doctor or pharmacist for personalized guidance before you start.
What side effects should I watch for?
The most common ones are body odor, diarrhea, nausea, vomiting, and stomach upset. Cerebral edema (brain swelling) is rare but serious. If you experience any unusual symptoms, stop and contact your doctor.
Will this help my cholesterol?
Elevated cholesterol levels are listed as a possible side effect of betaine, not a benefit. Talk with your doctor about whether this product is right for you if cholesterol is a concern.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Betaine Powder is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Betaine Powder label
Go deeper

The Full Monographs Behind Betaine Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph →
Sources

Sources & How We Checked

Betaine Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Betaine Anhydrous 11 references
  1. Cystadane (betaine anhydrous for oral solution) Package insert. Orphan Medical, Inc. Minnetonka, MN. November 2005.
  2. Abdelmalek MF, Angulo P, Jorgensen RA, et al. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol 2001;96:2711-7.. PubMed
  3. Schwab U, Torronen A, Toppinen L, et al. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr 2002;76:961-7. PubMed
  4. McGregor DO, Dellow WJ, Robson RA, et al. Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure. Kidney Int 2002;61:1040-6. PubMed
  5. Olthof MR, van Vliet T, Verhoef P, et al. Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans. PloS Med 2005;2:e135. PubMed
  6. Knopman, D. and Patterson, M. An open-label, 24-week pilot study of the methyl donor betaine in Alzheimer disease patients. Alzheimer Dis.Assoc.Disord. 2001;15(3):162-165. PubMed
  7. Moat, S. J., Madhavan, A., Taylor, S. Y., Payne, N., Allen, R. H., Stabler, S. P., Goodfellow, J., McDowell, I. F., Lewis, M. J., and Lang, D. High- but not low-dose folic acid improves endothelial function in coronary artery disease. Eur J Clin Invest 2 PubMed
  8. Abdelmalek, M. F., Sanderson, S. O., Angulo, P., Soldevila-Pico, C., Liu, C., Peter, J., Keach, J., Cave, M., Chen, T., McClain, C. J., and Lindor, K. D. Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. Hepa PubMed
  9. Ashtary-Larky D, Bagheri R, Ghanavati M, et al. Effects of betaine supplementation on cardiovascular markers: a systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2021 Mar 25:1-18. PubMed
  10. Zawieja EE, Zawieja B, Chmurzynska A. Betaine supplementation moderately increases total cholesterol levels: a systematic review and meta-analysis. J Diet Suppl. 2021;18(1):105-117. PubMed
  11. Imbard A, Toumazi A, Magréault S, et al. Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial. Orphanet J Rare Dis 2022;17(1):417. PubMed

See these in context on the Betaine Anhydrous monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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