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Dietary supplement

Bilberry Extra Strength Ingredients & Drug Interactions

by Yerba Prima

Bilberry Extra Strength label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bilberry Extra Strength against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bilberry Extra Strength is a dietary supplement by Yerba Prima with 1 active ingredient. Its ingredients are commonly taken for eye and vision health, antioxidant support, diarrhea and digestive upset.Based on those ingredients, 275 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bilberry fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bilberry Extra Strength by Yerba Prima

Ask about any prescription or over-the-counter medication and we check it for interactions with Bilberry Extra Strength by Yerba Prima — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bilberry Extra Strength by Yerba Prima

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: bilberry fruit extract. Bilberry is a dark berry rich in anthocyanidins, the pigments that give it its deep color and most of its studied effects.

The capsule also contains inactive ingredients — black pepper extract (which may help absorption), cellulose, and gelatin — but the active work comes from the bilberry itself.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: eye and vision health.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Diabetic retinopathy, Dry eye, Glaucoma — and 4 related terms.
  • The closest evidence on file: Bilberry is rated "Possibly Ineffective" for Night vision (Natural Medicines).
  • Also on file: Bilberry is rated "Insufficient Reliable Evidence To Rate" for Age-related macular degeneration (AMD), Cataracts, Diabetic retinopathy, Dry eye, and more.

The evidence for bilberry is limited and mixed. For night vision, the research suggests it's possibly ineffective — don't count on it to sharpen your sight.

For age-related cognitive decline, age-related macular degeneration, atherosclerosis, high cholesterol, and chronic venous insufficiency, we don't have enough reliable evidence to say whether it works or not. If you're considering this supplement for one of those purposes, talk it over with your doctor about whether the current evidence supports a trial.

The evidence, ingredient by ingredient Bilberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bilberry fruit as a food is well tolerated, but the safety data for concentrated supplements — like this extract — is limited and we lack long-term studies. The most common side effects are gastrointestinal: dark-colored stools, flatulence, and stomach discomfort.

In small trials, about a third of people reported flatulence, and some experienced temporary GI upset. You may also notice your stools, tongue, and even teeth turning dark blue or black — this is harmless staining from the bilberry pigment, not a sign of trouble.

Because safety evidence is thin, it's best to avoid supplement doses unless your doctor or pharmacist has cleared it for you.

Side effects, ingredient by ingredient Bilberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bilberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 275 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel, and others) — bilberry may increase bleeding risk. Also check if you're on diabetes medications, as bilberry might lower blood sugar further.

If you take erlotinib (Tarceva) for cancer, or any drug metabolized by the CYP2E1 enzyme, flag this product with your healthcare provider before adding it.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Bilberry Extra Strength may appeal to you if you're interested in antioxidant support, but the evidence that it works for any specific condition is weak or missing. If you take blood thinners, diabetes medications, or erlotinib, you'll need to check with your doctor or pharmacist before starting this supplement — the interaction risk is real.

Even if you're on no medications, the long-term safety isn't well established, so this is worth a quick conversation with your pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bilberry Extra Strength, straight from the product label.

Brand Yerba Prima
Barcode (UPC) 046352004563
Net contents 50 Capsule(s)
Market status On market
Date entered into DSLD Dec 26, 2020
DSLD ID 241537
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bilberry Extra Strength by Yerba Prima, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
UPC/BARCODE
046352004563
IngredientAmount% DV
Bilberry fruit extract160 mg--

Other ingredients: Bioperine Black Pepper extract, Cellulose, USP Kosher Gelatin Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Adult Usage: Normal use: 1 or 2 capsules daily, with or between meals. Intensive use: 3 capsules daily. Best used every day.

Just once daily

Storage

Store at room temperature. Keep lid tightly closed to protect from humidity.

General Statements

Note: Most herbal products, and most agricultural products, contain some chemicals that the plants absorb from the soil.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

BioPerine is a trademark of Sabinsa Corporation.

Yerba Prima 2013

Formulation

Made in U.S.A.

Promotes Eye Health

FDA Statement of Identity

Herbal Supplement

Formula

Yerba Prima Bilberry Extra Strength for the strongest Bilberry benefits. Yerba Prima Bilberry supports proper function of the eyes and helps maintain strength and flexibility of capillaries throughout the body. Contains Bioperine for maximum absorption.

Precautions

Safety Sealed: Do not use this product if printed band around cap or seal under cap is broken or missing. Caution: Do not take capsules if you have difficulty in swallowing.

If you are taking medication or are under a doctor’s care, consult a health professional before use.

California residents only: Proposition 65 Warning: This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. For more information about Prop 65, see www.yerbaprima.com.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bilberry Extra Strength by Yerba Prima label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bilberry Extra Strength label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bilberry Extra Strength by Yerba Prima

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Bilberry fruit extract

Interacts with
275 drugs
160 mg per serving Form: Anthocyanosides

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye healt...

Bilberry fruit extract monograph & interactions

Other (inactive) ingredients: Bioperine Black Pepper extract, Cellulose, USP Kosher Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bilberry Extra Strength by Yerba Prima Drug Interactions

Want to check YOUR meds against Bilberry Extra Strength?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
275Drugs
275 Moderate

Ingredients driving the most interactions

Bilberry fruit extract 275

Individual Drug Interactions

The ingredients in Bilberry Extra Strength interact with 275 drugs. Click any drug to see the details.

1 of the 1 ingredient in Bilberry Extra Strength interact with drugs. Each result below shows which ingredient is responsible. Bilberry fruit extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Bilberry Extra Strength with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bilberry fruit extract4 drug types · 275 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Erlotinib (Tarceva)

Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Bilberry fruit extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bilberry Extra Strength, from the product label.

Yerba Prima

See all Yerba Prima products
Name
Yerba Prima, Inc.
Street Address
740 Jefferson Ave.
City
Ashland
State
OR
ZipCode
97520
Web Address
www.yerbaprima.com
Pharmacist Counseling Corner

Bilberry Extra Strength by Yerba Prima: Common Questions

Does Bilberry Extra Strength by Yerba Prima interact with any medications?
Yes. Based on its ingredients, Bilberry Extra Strength has a known interaction with 275 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bilberry Extra Strength contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does bilberry actually help your eyesight?
The research says it's possibly ineffective for night vision. We don't have enough solid evidence to recommend it for improving eyesight, so don't expect it to sharpen your vision based on current studies.
What are the side effects?
Most people tolerate it well. The common ones are gastrointestinal — dark stools, gas, and mild stomach discomfort. You may also notice your stools and tongue turning dark blue or black from the bilberry pigment, which is harmless staining.
Is it safe to take if I'm pregnant or breastfeeding?
Bilberry is rated as likely safe during pregnancy and lactation. That said, supplement safety data is limited overall, so talk with your doctor or midwife about whether it's right for your situation before taking it.
What's the black pepper extract in here for?
Black pepper extract (bioperine) is included to help your body absorb the bilberry better. It's an inactive ingredient that enhances the active ingredient's delivery.
Can I take this with food?
The facts don't address how to time it with food, so ask your pharmacist or the manufacturer for their recommendation on when to take it for best results.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bilberry Extra Strength is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bilberry Extra Strength label
Go deeper

The Full Monographs Behind Bilberry Extra Strength’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bilberry

Interacts with 275 drugs

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While...

Read the full Bilberry monograph →
Sources

Sources & How We Checked

Bilberry Extra Strength's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bilberry 14 references
  1. Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
  2. Morazzoni P, Magistretti MJ. Activity of Myrtocyan, an anthosyanoside complex from Vaccinium myrtillus (VMA), on platelet aggregation and adhesiveness. Fitoterapia 1990;61:13-21.
  3. Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., and Jula, A. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008;87(2):323-331. PubMed
  4. Hawrelak, J. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. J Altern Complement Med 2010;16(10):1065-1071. PubMed
  5. Morazzoni P and Magistretti MJ. Effects of Vaccinium myrtillus anthocyanosides on prostacyclin-like activity in rat arterial issue. Fitoterapia 1986;57:11-14.
  6. Pulliero G, Montin S, Bettini V, and et al. Ex vivo study of the inhibitory effects of Vaccinium myrtillus anthocyanosides on human platelet aggregation. Fitoterapia 1989;60:69-75.
  7. Bottecchia D. Preliminary report on the inhibitory effect of vaccinium myrtillus anthocyanosides on platelet aggregation and clot retraction. Fitoterapia 1987;48:3-8.
  8. Fdez, M., Zaragoza, F., and Alvarez, P. In vitro platelet aggregation effects of anthocyanosides of vaccinium myrtilus L. Anales de la Real Academia de Farmacia 1983;49:79-90.
  9. Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis-an open pilot study. 2013 May;7(4):271-9. PubMed
  10. Hoggard N, Cruickshank M, Moar KM, Bestwick C, Holst J, Russell W, et al. A single supplement of a standardized bilberry (Vaccinium myrtillus L.) extract (36% wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes control
  11. Aichinger G, Pahlke G, Nagel LJ, Berger W, Marko D. Bilberry extract, its major phenolic compounds, and soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells. Food Funct 2016;7(8):3628-36.
  12. Prokop J, Lněničková K, Cibicek N, et al. Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. Food Chem Toxicol 2019;129:382-90. PubMed
  13. Chan SW, Chu TTW, Choi SW, Benzie IFF, Tomlinson B. Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytother Res 2021. Online ahead o PubMed
  14. Bøhn SK, Myhrstad MCW, Thoresen M, et al. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial. BMC Nutr 2021;7(1):75. PubMed

See these in context on the Bilberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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