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Dietary supplement

Bilberry Plus 6000 mg Ingredients & Drug Interactions

by SimplySupplements

Bilberry Plus 6000 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bilberry Plus 6000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bilberry Plus 6000 mg is a dietary supplement by SimplySupplements with 1 active ingredient. Its ingredients are commonly taken for eye and vision health, antioxidant support, diarrhea and digestive upset.Based on those ingredients, 275 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bilberry Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bilberry Plus 6000 mg by SimplySupplements

Ask about any prescription or over-the-counter medication and we check it for interactions with Bilberry Plus 6000 mg by SimplySupplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bilberry Plus 6000 mg by SimplySupplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Bilberry Plus 6000 mg contains one active ingredient: bilberry extract, a concentrate from bilberry fruit. The tablet also contains microcrystalline cellulose, magnesium stearate, and silicon dioxide as inactive ingredients (binders and flow agents that help hold the tablet together).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Bilberry's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: antioxidant support for eyes and body health.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Chronic venous insufficiency (CVI), Diabetic retinopathy, Dry eye — and 4 related terms.
  • The closest evidence on file: Bilberry is rated "Possibly Ineffective" for Night vision (Natural Medicines).
  • Also on file: Bilberry is rated "Insufficient Reliable Evidence To Rate" for Age-related macular degeneration (AMD), Cataracts, Chronic venous insufficiency (CVI), Diabetic retinopathy, and more.

The evidence for bilberry extract is mixed and often limited. For night vision, the data suggests it's possibly ineffective.

For age-related cognitive decline, age-related macular degeneration, atherosclerosis, high cholesterol, and chronic venous insufficiency (poor circulation in the legs), we don't have enough reliable evidence to say whether it works. The facts we hold don't establish a clear benefit for any of these conditions.

The evidence, ingredient by ingredient Bilberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bilberry fruit in food amounts is generally well tolerated, but the safety data for concentrated supplements is sparse and long-term safety isn't well studied. The safety notes advise caution — supplement doses are used without enough reliable safety information.

The most common side effects from bilberry are dark-colored stools, flatulence, and mild stomach discomfort. In some trials, around a third of participants reported mild-to-moderate gas, and temporary stomach upset occurred in a smaller number.

You may also notice dark discoloration of your stools, tongue, or even teeth — this is harmless staining from the extract's natural color.

Side effects, ingredient by ingredient Bilberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bilberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 275 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Bilberry Plus, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin, clopidogrel, or aspirin) — bilberry may increase bleeding risk. Also double-check if you take diabetes medications, since bilberry may lower blood sugar further.

If you're on erlotinib (a cancer drug) or any medication metabolized by the liver enzyme CYP2E1, mention this product too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Bilberry extract is not well proven for any of the conditions it's marketed for, and concentrated supplement forms lack solid long-term safety data. If you take blood thinners, diabetes medications, or erlotinib, this product is worth discussing with your doctor or pharmacist first.

For most others, the main caution is limited evidence of benefit and the lack of robust safety testing in supplement form.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bilberry Plus 6000 mg, straight from the product label.

Brand SimplySupplements
Barcode (UPC) 5060208418217
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Jul 25, 2013
DSLD ID 22397
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bilberry Plus 6000 mg by SimplySupplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
5060208418217
IngredientAmount% DV
Bilberry Extract600 mg--

Other ingredients: Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

SimplySupplements(TM)

QUALITY ASSURED

V

General Statements

MAX STRENGTH

Natural source of powerful antioxidants

Product Information Bilberry is increasingly recommended by medical practitioners as its antioxidant properties may help to support the maintenance of the body's natural free radical defences throughout the body and the eyes.

Image is for illustration purposes only.

AutoDespatch SAVE 10% and get FREE P&P on all repeat orders by having your favourite supplements conveniently scheduled and delivered automatically with our unique AutoDespatch system. Same Day Despatch We will ensure your order is despatched on the day of receipt (when placed before 12.30pm) and that all orders placed after 12.30pm are despatched on the next working day. All sent 1st class! PriceMatch Guarantee! If you buy from us and then see the same product cheaper elsewhere we will refund the difference plus 10%!

Suggested/Recommended/Usage/Directions

Suggested Daily Intake Take one tablet daily as a food supplement or as directed by a healthcare professional.

Precautions

Important Information If you are taking any prescription medication, you have a medical condition or you have specific concerns about the suitability of our products, always consult your GP or Pharmacist prior to taking supplements.

Do not exceed stated dose.

Keep away from children at all times.

Do not use if seal is broken.

Pregnant or lactating women should consult a Doctor before using this product.

Food supplement: This product should not be used as a substitute for a varied diet.

Storage

Store in a cool dry place.

Formulation

Suitable for Vegetarians.

General

S499

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bilberry Plus 6000 mg by SimplySupplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bilberry Plus 6000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bilberry Plus 6000 mg by SimplySupplements

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Bilberry Extract

Interacts with
275 drugs
600 mg per serving

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye healt...

Bilberry Extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bilberry Plus 6000 mg by SimplySupplements Drug Interactions

Want to check YOUR meds against Bilberry Plus 6000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
275Drugs
275 Moderate

Ingredients driving the most interactions

Bilberry Extract 275

Individual Drug Interactions

The ingredients in Bilberry Plus 6000 mg interact with 275 drugs. Click any drug to see the details.

1 of the 1 ingredient in Bilberry Plus 6000 mg interact with drugs. Each result below shows which ingredient is responsible. Bilberry Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Bilberry Plus 6000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bilberry Extract4 drug types · 275 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Erlotinib (Tarceva)

Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Bilberry Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bilberry Plus 6000 mg, from the product label.

SimplySupplements

See all SimplySupplements products
Phone Number
0800 988 0292
Pharmacist Counseling Corner

Bilberry Plus 6000 mg by SimplySupplements: Common Questions

Does Bilberry Plus 6000 mg by SimplySupplements interact with any medications?
Yes. Based on its ingredients, Bilberry Plus 6000 mg has a known interaction with 275 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bilberry Plus 6000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does bilberry really help with eyesight or night vision?
For night vision, the evidence suggests it's not effective. For other eye conditions like age-related macular degeneration, we don't have enough reliable data to know if it works. The hype around bilberry and vision is stronger than what the research actually shows.
Is bilberry safe to take while I'm pregnant or breastfeeding?
Bilberry is rated as likely safe in pregnancy and lactation. That said, the safety data on concentrated supplements is limited, so it's worth talking to your doctor or midwife before starting.
What are the side effects?
Bilberry is generally well tolerated. The most common side effects are dark stools, gas, and mild stomach discomfort. You may also notice dark staining of your tongue, teeth, or stools — that's just the berry's natural color and isn't harmful.
Will bilberry turn my stool black or dark?
Yes, it can. The dark pigments in bilberry extract may stain your stools dark blue, green, or black, and occasionally your tongue or teeth too. This is harmless and temporary — it stops when you stop taking the supplement.
Can I take this if I'm on blood thinners or aspirin?
Bilberry may theoretically increase bleeding risk when combined with blood thinners or antiplatelet drugs. Check with your doctor or pharmacist before adding this product to your routine if you take any of these medications.
Will this lower my blood sugar if I'm diabetic?
Bilberry extract may theoretically increase the risk of low blood sugar when taken alongside diabetes medications. If you take diabetes drugs, mention this product to your pharmacist or doctor before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bilberry Plus 6000 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bilberry Plus 6000 mg label
Go deeper

The Full Monographs Behind Bilberry Plus 6000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bilberry

Interacts with 275 drugs

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While...

Read the full Bilberry monograph →
Sources

Sources & How We Checked

Bilberry Plus 6000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bilberry 14 references
  1. Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
  2. Morazzoni P, Magistretti MJ. Activity of Myrtocyan, an anthosyanoside complex from Vaccinium myrtillus (VMA), on platelet aggregation and adhesiveness. Fitoterapia 1990;61:13-21.
  3. Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., and Jula, A. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008;87(2):323-331. PubMed
  4. Hawrelak, J. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. J Altern Complement Med 2010;16(10):1065-1071. PubMed
  5. Morazzoni P and Magistretti MJ. Effects of Vaccinium myrtillus anthocyanosides on prostacyclin-like activity in rat arterial issue. Fitoterapia 1986;57:11-14.
  6. Pulliero G, Montin S, Bettini V, and et al. Ex vivo study of the inhibitory effects of Vaccinium myrtillus anthocyanosides on human platelet aggregation. Fitoterapia 1989;60:69-75.
  7. Bottecchia D. Preliminary report on the inhibitory effect of vaccinium myrtillus anthocyanosides on platelet aggregation and clot retraction. Fitoterapia 1987;48:3-8.
  8. Fdez, M., Zaragoza, F., and Alvarez, P. In vitro platelet aggregation effects of anthocyanosides of vaccinium myrtilus L. Anales de la Real Academia de Farmacia 1983;49:79-90.
  9. Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis-an open pilot study. 2013 May;7(4):271-9. PubMed
  10. Hoggard N, Cruickshank M, Moar KM, Bestwick C, Holst J, Russell W, et al. A single supplement of a standardized bilberry (Vaccinium myrtillus L.) extract (36% wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes control
  11. Aichinger G, Pahlke G, Nagel LJ, Berger W, Marko D. Bilberry extract, its major phenolic compounds, and soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells. Food Funct 2016;7(8):3628-36.
  12. Prokop J, Lněničková K, Cibicek N, et al. Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. Food Chem Toxicol 2019;129:382-90. PubMed
  13. Chan SW, Chu TTW, Choi SW, Benzie IFF, Tomlinson B. Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytother Res 2021. Online ahead o PubMed
  14. Bøhn SK, Myhrstad MCW, Thoresen M, et al. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial. BMC Nutr 2021;7(1):75. PubMed

See these in context on the Bilberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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