Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Blood Sugar Balance 335 mg Ingredients & Drug Interactions

by Eclectic Herb

Blood Sugar Balance 335 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Blood Sugar Balance 335 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Blood Sugar Balance 335 mg is a dietary supplement by Eclectic Herb with 5 active ingredients. Its ingredients are commonly taken for blood sugar support, diabetes, digestive complaints.Based on those ingredients, 465 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bitter Melon Fruit Concentrate, Freeze-Dried, Huckleberry Leaf Concentrate, Freeze-Dried, Prickly Pear Leaf Pad Concentrate, Freeze-Dried. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Blood Sugar Balance 335 mg by Eclectic Herb

Ask about any prescription or over-the-counter medication and we check it for interactions with Blood Sugar Balance 335 mg by Eclectic Herb — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Blood Sugar Balance 335 mg by Eclectic Herb

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Proprietary Blend Of Freeze-Dried Concentrated” is a proprietary blend — the label gives one combined amount (670 mg) without saying how much of each component you get.

This product contains five active ingredients: bitter melon fruit, green bean pod, huckleberry leaf (which is bilberry), prickly pear cactus leaf pad, and devil's club root bark — all in freeze-dried concentrated form. These are traditional botanicals historically used to support blood sugar levels.

The product also contains hypromellose (a capsule material).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Blood sugar balance and support.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), Hypercholesterolemia, Hyperlipidemia, Metabolic syndrome, Glycemic control — and 1 related terms.
  • The strongest evidence on file: Prickly Pear Cactus is rated "Possibly Effective" for Diabetes (Natural Medicines).
  • Also on file: Bilberry is rated "Insufficient Reliable Evidence To Rate" for Diabetes, Hyperlipidemia, Impaired glucose tolerance (prediabetes), Metabolic syndrome.
  • Also on file: Bitter Melon is rated "Insufficient Reliable Evidence To Rate" for Diabetes, Impaired glucose tolerance (prediabetes).

The evidence for bitter melon in diabetes is insufficient — we hold no reliable data showing it works for blood sugar control. Prickly pear cactus is rated possibly effective for diabetes based on available research, but the other ingredients lack established effectiveness ratings in our data.

If blood sugar support is your goal, the evidence for this specific blend is limited, and you should talk with your doctor about proven options.

The evidence, ingredient by ingredient Bitter Melon Bilberry Prickly Pear Cactus Devil's Club

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bitter melon is generally well tolerated as food, but supplement doses may lower blood sugar and cause stomach upset, and high doses or seeds are traditionally avoided in pregnancy. The most common side effects in studies are gastrointestinal — heartburn, nausea, vomiting, diarrhea, constipation, and abdominal discomfort occurred in about 3 to 16 percent of people taking bitter melon.

Bilberry fruit is likely safe during pregnancy and lactation in normal food amounts, but concentrated supplements lack long-term safety data, so they should be avoided at high doses in pregnancy and while nursing. Prickly pear cactus is generally well tolerated; the most common side effects are mild and gastrointestinal (mild diarrhea, nausea, dyspepsia, abdominal fullness).

Devil's club has limited human safety data and should be used cautiously — reported side effects include diarrhea, nausea, vomiting, and lightheadedness. Avoid devil's club during pregnancy and breastfeeding due to lack of safety information.

Altogether, these interactions span 464 individual medications.

Side effects, ingredient by ingredient Bitter Melon Bilberry Prickly Pear Cactus Devil's Club

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Bilberry, Bitter Melon, Prickly Pear Cactus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 465 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking if you use diabetes medications (blood sugar drugs) — bitter melon, bilberry, and prickly pear all lower blood sugar and may cause dangerously low levels when combined. Tell your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin or aspirin), because bilberry may increase bleeding risk.

If you take any P-glycoprotein substrate drugs, pazopanib (a cancer medication), erlotinib (another cancer drug), or drugs metabolized by the liver enzyme CYP2E1, check with your pharmacist first — bitter melon and bilberry may affect how these work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is aimed at people looking for traditional herbal support for blood sugar, but the evidence for most of its ingredients is limited or absent. If you take any diabetes medication, blood thinner, cancer drug, or any prescription at all, check with your doctor or pharmacist before starting — the ingredient list carries documented interactions that could affect how your medicines work or increase your risk of low blood sugar.

Devil's club and bilberry at concentrated doses also lack solid long-term safety data, so talk this over with your pharmacist or doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Blood Sugar Balance 335 mg, straight from the product label.

Brand Eclectic Herb
Barcode (UPC) 023363324149
Net contents 45 Veg Cap(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 316746
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Blood Sugar Balance 335 mg by Eclectic Herb, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veg Cap(s)
Maximum serving Sizes:
2 Veg Cap(s)
Servings per container
22
UPC/BARCODE
023363324149
IngredientAmount% DV
Proprietary Blend Of Freeze-Dried Concentrated670 mg--
Bitter Melon Fruit Concentrate, Freeze-Dried0 NP--
Green Bean Pod Concentrate, Freeze-dried0 NP--
Huckleberry Leaf Concentrate, Freeze-Dried0 NP--
Prickly Pear Leaf Pad Concentrate, Freeze-Dried0 NP--
Devil's Club Root Bark Concentrate, Freeze-Dried0 NP--

Other ingredients: Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Concentrated 3 1/2 X through freeze-drying Freeze dried for peak plant power

100% Kosher

Created by a naturopathic physician, our formulas deliver the concentrated benefits of multiple botanicals in a single capsule. Using only traditional processes of juicing, decocting and freeze-drying, we combine whole herbs with plant compounds. From farm to bottle, we use naturopathic wisdom and innovative processes to create exceptional products.

Formulation

No fillers Non GMO Gluten free

Whole herb Naturopathic formulated Naturally concentrated

Vegan

Metabolism support Small batch freeze dried

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent disease.

General Statements

@Eclecticherb

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Take 2 capsules as needed.

Precautions

Keep away from children. Consult your doctor about herbs with pregnancy, infants or prescription drugs.

Consult your doctor about herbs with pregnancy, infants or prescription drugs. Warning: Do not use if insulin-dependant

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Blood Sugar Balance 335 mg by Eclectic Herb label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Blood Sugar Balance 335 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Blood Sugar Balance 335 mg by Eclectic Herb

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Veg Cap(s) Dosage formCapsule Servings per container22 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend Of Freeze-Dried Concentrated

670 mg per serving

Other (inactive) ingredients: Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Blood Sugar Balance 335 mg by Eclectic Herb Drug Interactions

Want to check YOUR meds against Blood Sugar Balance 335 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
465Drugs
465 Moderate

Ingredients driving the most interactions

Bitter Melon Fruit Concentrate, Freeze-Dried 283
Huckleberry Leaf Concentrate, Freeze-Dried 275
Prickly Pear Leaf Pad Concentrate, Freeze-Dried 86

Individual Drug Interactions

The ingredients in Blood Sugar Balance 335 mg interact with 465 drugs. Click any drug to see the details.

3 of the 5 ingredients in Blood Sugar Balance 335 mg interact with drugs. Each result below shows which ingredient is responsible. Bitter Melon Fruit Concentrate, Freeze-Dried Huckleberry Leaf Concentrate, Freeze-Dried Prickly Pear Leaf Pad Concentrate, Freeze-Dried

Each ingredient & the kinds of drugs it affects

For each ingredient in Blood Sugar Balance 335 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bitter Melon Fruit Concentrate, Freeze-Dried3 drug types · 283 drugs

Antidiabetes Drugs

Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Bitter melon can lower blood glucose levels and might have additive effects when used with antidiabetes drugs. This might increase the risk of hypoglycemia in some patients. Monitor blood glucose levels closely.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Bitter melon might inhibit the p-glycoprotein (P-gp) intestinal pump and increase intracellular levels of P-gp substrates. In vitro research in intestinal cells shows that 1-monopalmitin, a constituent of bitter melon, increases levels of daunomycin, a P-gp substrate. Additionally, drinking bitter melon juice has been associated with a case of acute pancreatitis in a patient who had been taking pazopanib, a P-gp substrate, for 8 years. Researchers theorize that inhibition of P-gp led to increased levels of pazopanib, resulting in pazopanib-induced pancreatitis.

Likelihood Possible Evidence D
Pazopanib (Votrient)

Theoretically, bitter melon might increase levels of pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 8 years for renal cell carcinoma experienced signs and symptoms consistent with acute pancreatitis 4 days after drinking bitter melon juice at a dose of 100-150 mL daily. The patient's symptoms, amylase levels, and lipase levels improved upon discontinuation of bitter melon and pazopanib. Pazopanib treatment was re-initiated with no further evidence of pancreatitis. Researchers theorize that inhibition of P-glycoprotein by bitter melon led to increased levels of pazopanib, a P-glycoprotein substrate, resulting in pazopanib-induced pancreatitis.

Likelihood Possible Evidence D
Bitter Melon Fruit Concentrate, Freeze-Dried full monograph & interactions

Huckleberry Leaf Concentrate, Freeze-Dried4 drug types · 275 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Erlotinib (Tarceva)

Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Huckleberry Leaf Concentrate, Freeze-Dried full monograph & interactions

Prickly Pear Leaf Pad Concentrate, Freeze-Dried1 drug type · 86 drugs

Antidiabetes Drugs

Combining prickly pear cactus with antidiabetes drugs might increase the risk of hypoglycemia.
Case reports show that combining prickly pear cactus with antidiabetes drugs such as chlorpropamide, glyburide, glipizide, and metformin can increase the risk of hypoglycemia in patients with type 2 diabetes. Advise patients to monitor glucose levels closely. Dose adjustments may be necessary.

Likelihood Probable Evidence D
Prickly Pear Leaf Pad Concentrate, Freeze-Dried full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Blood Sugar Balance 335 mg, from the product label.

Eclectic Herb

See all Eclectic Herb products
Name
Eclectic Herb
Street Address
755 NE 6th St.
City
Gresham
State
Oregon
ZipCode
97030
Phone Number
503.668.4120
Web Address
www.eclecticherb.com
Pharmacist Counseling Corner

Blood Sugar Balance 335 mg by Eclectic Herb: Common Questions

Does Blood Sugar Balance 335 mg by Eclectic Herb interact with any medications?
Yes. Based on its ingredients, Blood Sugar Balance 335 mg has a known interaction with 465 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Blood Sugar Balance 335 mg contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Bitter melon and prickly pear should be avoided at supplement doses during pregnancy and while nursing — there isn't enough safety data. Bilberry fruit is likely safe in normal food amounts during both, but concentrated supplements are best avoided. Devil's club has not been studied in pregnancy or lactation, so it should be avoided. Talk with your doctor or pharmacist about what's right for you.
What are the most common side effects?
The most common are gastrointestinal: heartburn, nausea, vomiting, diarrhea, constipation, and stomach discomfort. Bilberry may also cause dark-colored or dark-green stools and flatulence. These occurred in about 3 to 16 percent of people taking bitter melon in studies, and in about 33 percent taking bilberry in one small trial, though that study had limitations.
Does this actually work for blood sugar?
Prickly pear cactus is rated possibly effective for diabetes based on the evidence we have. Bitter melon is not rated — the evidence is insufficient to say whether it works. The other ingredients have no effectiveness ratings in our data. Talk with your doctor about proven options for managing your blood sugar.
Why is there such a big number of medication interactions?
That total spans 464 individual medications across all the ingredients combined. Most come from P-glycoprotein substrates and CYP2E1 substrates — these are broad categories that include many different drugs your liver processes or your intestines absorb in specific ways. The main actionable concerns are diabetes drugs, blood thinners, and cancer medications — check those specifically with your pharmacist.
What if I'm taking a diabetes medication?
All three main ingredients in this blend — bitter melon, bilberry, and prickly pear — can lower blood sugar on their own. Combined with a diabetes drug, they increase your risk of hypoglycemia (dangerously low blood sugar). Check with your doctor or pharmacist before starting, and if you do take it, monitor your blood sugar closely.
Is green bean pod safe?
We have no interaction data on file for green bean pod concentrate, so we could not check it. Ask your pharmacist if you have concerns about that specific ingredient.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Blood Sugar Balance 335 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Blood Sugar Balance 335 mg label
Go deeper

The Full Monographs Behind Blood Sugar Balance 335 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bitter Melon

Interacts with 283 drugs

Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control. While some small studies hint it may modestly lower blood sugar, the evid...

Read the full Bitter Melon monograph → Herb & supplement monograph

Bilberry

Interacts with 275 drugs

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While...

Read the full Bilberry monograph → Herb & supplement monograph

Prickly Pear Cactus

Interacts with 86 drugs

Prickly pear cactus is a desert plant whose pads and fruit are eaten as food and taken as a supplement, mainly for blood sugar, cholesterol, and hangover symptoms. Some small studies suggest...

Read the full Prickly Pear Cactus monograph → Herb & supplement monograph

Devil's Club

Devil's Club is a thorny shrub from the Pacific Northwest of North America that has long been used in Indigenous traditional medicine, especially for blood sugar and respiratory complaints....

Read the full Devil's Club monograph →
Sources

Sources & How We Checked

Blood Sugar Balance 335 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 43 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bitter Melon 18 references
  1. Leatherdale B, Panesar RK, Singh G, et al. Improvement in glucose tolerance due to Momordica charantia. Br Med J (Clin Res Ed) 1981;282:1823-4.
  2. Welihinda J, et al. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol 1986;17:277-82. PubMed
  3. Srivastava Y, Venkatakrishna-Bhatt H, Verma Y, et al. Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation. Phytother Res 1993;7:285-9.
  4. Baldwa VS, Bhandari CM, Pangaria A, Goyal RK. Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant sources. Ups J Med Sci 1977;82:39-41. PubMed
  5. Aslam M, Stockley IH. Interaction between curry ingredient (karela) and drug (chlorpropamide). Lancet 1979:1:607. PubMed
  6. Ahmad N, Hassan MR, Halder H, Bennoor KS. Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients (abstract). Bangladesh Med Res Counc Bull 1999;25:11-3.
  7. Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm 2003;60:356-9. PubMed
  8. Yin RV, Lee NC, Hirpara H, Phung OJ. T. The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: s systematic review and meta-analysis. Nutr Diabetes. 2014;4:e145.
  9. Rahman IU, Khan RU, Rahman KU, Bashir M. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J. 2015;14:13. PubMed
  10. Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. PubMed
  11. Konishi T, Satsu H, Hatsugai Y, et al. Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br J Pharmacol. 2004;143(3):379-87. PubMed
  12. Peter EL, Kasali FM, Deyno S, et al. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis. J Ethnopharmacol. 2019;231:311-24. doi: 10.1016/j.jep.2018.10.033. PubMed
  13. Cortez-Navarrete M, Martínez-Abundis E, Pérez-Rubio KG, González-Ortiz M, Méndez-Del Villar M. Momordica charantia administration improves insulin secretion in type 2 diabetes mellitus. J Med Food. 2018;21(7):672-7. doi: 10.108
  14. Kim SK, Jung J, Jung JH, et al. Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus. Complement Ther Med. 2020 Aug;52:102524. doi: 10.1016/j.ctim.2020.102524. PubMed
  15. Unsal O, Sütcüoglu O, Yazici O. Dangerous interaction of bitter melon (Momordica charantia) with pazopanib: a case of acute pancreatitis. J Oncol Pharm Pract 2022;28(2):486-8.
  16. Bae W, Kim S, Choi J, et al. Acute interstitial nephritis associated with ingesting a Momordica charantia extract: a case report. Medicine (Baltimore) 2021;100(27):e26606. PubMed
  17. Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
  18. Kim B, Lee HS, Kim HJ, et al. Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study. Food Sci Biotechnol 2022;32(5):697-704. PubMed

See these in context on the Bitter Melon monograph →

Bilberry 14 references
  1. Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
  2. Morazzoni P, Magistretti MJ. Activity of Myrtocyan, an anthosyanoside complex from Vaccinium myrtillus (VMA), on platelet aggregation and adhesiveness. Fitoterapia 1990;61:13-21.
  3. Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., and Jula, A. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008;87(2):323-331. PubMed
  4. Hawrelak, J. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. J Altern Complement Med 2010;16(10):1065-1071. PubMed
  5. Morazzoni P and Magistretti MJ. Effects of Vaccinium myrtillus anthocyanosides on prostacyclin-like activity in rat arterial issue. Fitoterapia 1986;57:11-14.
  6. Pulliero G, Montin S, Bettini V, and et al. Ex vivo study of the inhibitory effects of Vaccinium myrtillus anthocyanosides on human platelet aggregation. Fitoterapia 1989;60:69-75.
  7. Bottecchia D. Preliminary report on the inhibitory effect of vaccinium myrtillus anthocyanosides on platelet aggregation and clot retraction. Fitoterapia 1987;48:3-8.
  8. Fdez, M., Zaragoza, F., and Alvarez, P. In vitro platelet aggregation effects of anthocyanosides of vaccinium myrtilus L. Anales de la Real Academia de Farmacia 1983;49:79-90.
  9. Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis-an open pilot study. 2013 May;7(4):271-9. PubMed
  10. Hoggard N, Cruickshank M, Moar KM, Bestwick C, Holst J, Russell W, et al. A single supplement of a standardized bilberry (Vaccinium myrtillus L.) extract (36% wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes control
  11. Aichinger G, Pahlke G, Nagel LJ, Berger W, Marko D. Bilberry extract, its major phenolic compounds, and soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells. Food Funct 2016;7(8):3628-36.
  12. Prokop J, Lněničková K, Cibicek N, et al. Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. Food Chem Toxicol 2019;129:382-90. PubMed
  13. Chan SW, Chu TTW, Choi SW, Benzie IFF, Tomlinson B. Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytother Res 2021. Online ahead o PubMed
  14. Bøhn SK, Myhrstad MCW, Thoresen M, et al. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial. BMC Nutr 2021;7(1):75. PubMed

See these in context on the Bilberry monograph →

Prickly Pear Cactus 9 references
  1. Meckes-Lozyoa M, Roman-Ramos R. Opuntia streptacantha; a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14:116-8.
  2. Rayburn K, Martinez R, Escobedo M, et al. Glycemic effects of various species of nopal (Opuntia sp.) in type 2 diabetes mellitus. Texas J Rural Health 1998;26:68-76.
  3. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  4. Sobieraj DM, Freyer CW. Probable hypoglycemic adverse drug reaction associated with prickly pear cactus, glipizide, and metformin in a patient with type 2 diabetes mellitus. Ann Pharmacother 2010;44:1334-7. PubMed
  5. Kleiner, O., Cohen, Z., and Mares, A. J. Low colonic obstruction due to Opuntia ficus indica seeds: the aftermath of enjoying delicious cactus fruits. Acta Paediatr. 2002;91(5):606-607.
  6. Steinberg, J. M. and Eitan, A. Prickly pear fruit bezoar presenting as rectal perforation in an elderly patient. Int J Colorectal Dis. 2003;18(4):365-367. PubMed
  7. Meckes-Lozyoa, M. and Roman-Ramos, R. Opuntia streptacantha: a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14(3-4):116-118.
  8. Onakpoya IJ, O'Sullivan J, Heneghan CJ. The effect of cactus pear (Opuntia ficus-indica) on body weight and cardiovascular risk factors: a systematic review and meta-analysis of randomized clinical trials. Nutrition. 2015;31(5):640-6. PubMed
  9. Han EH, Lim MK, Lee S, et al. Efficacy of Ethanolic Extract of Opuntia ficus-indica var. saboten Stems for Improving Cognitive Function in Elderly Subjects 55-85 Years of Age: A Randomized, Double-Blind, Placebo-Controlled Study. J Med Food 2020;23(11):11

See these in context on the Prickly Pear Cactus monograph →

Devil's Club 2 references
  1. Turner NJ, Thompson LC Thompson MT York AZ. Thompson Ethnobotany: Knowledge and Usage of Plants by the Thompson Indians of British Columbia. 1990.
  2. Thommasen HV, Wilson RA, McIlwain RG. Effect of Devil's Club Tea on Blood Glucose Levels in Diabetes Mellitus. Can Fam Physician. 1990;36:62-5.

See these in context on the Devil's Club monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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