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Creatine is an organic amine that occurs naturally in the body and is also found in certain foods, such as meat and fish. It is stored mostly in the skeletal muscles, where it is used to generate energy during physical activity. Creatine is a popular over-the-counter dietary supplement, and some evidence suggests it is effective at improving exercise performance, particularly during high-intensity activities such as weightlifting and sprinting. However, the degree to which creatine supplements may improve exercise performance can vary depending on the individual and the type of physical activity being performed Creatine is generally well-tolerated but may cause some minor side effects, such as cramping and water retention in some individuals. Long-term use has been rarely linked to kidney problems, but its use is generally regarded as safe. There are several different forms of creatine available, with the most common form being monohydrate salt. Other salt forms, including di-creatine citrate and 'pH buffered' creatine, are also available.

L-tyrosine is a non-essential amino acid produced within the body through the conversion of the essential amino acid, phenylalanine. It is often used as a dietary supplement to support cognitive function, enhance focus, and mitigate stress by serving as a precursor for neurotransmitters like dopamine and norepinephrine.

Hordenine is a naturally occurring alkaloid found in various plants, including barley and cacti. It is structurally related to epinephrine and ephedrine and gets its name from the Hordeum genus of barley, from which it was first isolated. Hordenine has been marketed as a dietary supplement with claims of boosting energy and athletic performance, but there is limited scientific evidence to support these claims. Some studies suggest that it may have properties as a stimulant, but further research is needed to confirm its effects and safety.