Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Cartiflex Ingredients & Drug Interactions

by Quality of Life

Cartiflex label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cartiflex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cartiflex is a dietary supplement by Quality of Life with 2 active ingredients. Its ingredients are commonly taken for osteoarthritis joint pain, joint stiffness, cartilage support.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chondroitin Sulfate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cartiflex by Quality of Life

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HelloPharmacist Scorecard of Cartiflex by Quality of Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,200 mg) without saying how much of each component you get.
  • “BioCell Collagen” is listed as a grouped ingredient — the label gives one combined amount (600 mg) without saying how much of each component you get.

Cartiflex has 2 active ingredients. Chondroitin sulfate is a compound found in cartilage that's used to support joint health and has been studied for osteoarthritis and cataracts.

Hyaluronic acid is a natural substance that holds water and is used to support skin hydration and eye comfort. The product also contains inactive ingredients (microcrystalline cellulose and leucine) that help form the capsule and deliver the actives.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Joint flexibility mobility and cartilage support.
  • We looked for evidence on: Osteoarthritis, Joint stiffness, Cartilage degradation, Age-related joint decline.
  • The strongest evidence on file: Chondroitin Sulfate is rated "Possibly Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Hyaluronic Acid is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis.

Chondroitin sulfate is possibly effective for osteoarthritis and cataracts, meaning there's some evidence it may help, but the proof isn't ironclad. There isn't enough reliable evidence to say whether it works for aging skin, bone loss (osteoporosis), high cholesterol, or colon polyp prevention.

Hyaluronic acid is possibly effective for dry eye and venous leg ulcers; the evidence for it and aging skin, hay fever, or sexual dysfunction is insufficient. The benefit of this combination for joint health is not established in our data.

The evidence, ingredient by ingredient Chondroitin Sulfate

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chondroitin is generally well tolerated for short-term use, though quality varies. The most common side effects taken by mouth are abdominal pain, bloating, constipation, diarrhea, heartburn, and nausea.

Rare serious side effects include liver damage. Chondroitin has also been linked to skin symptoms like eyelid or leg swelling, hair loss, and rash—and when combined with glucosamine, possibly hives and water retention around the eyes.

One case of asthma getting worse and one case of sun sensitivity (photosensitization) have been reported with glucosamine-chondroitin products. Hyaluronic acid is also generally well tolerated when taken by mouth or applied to skin, though long-term safety of oral supplements hasn't been fully studied.

The safety data advises against chondroitin during pregnancy and while breastfeeding. For hyaluronic acid, there isn't enough data to know either way in pregnancy or lactation—talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Chondroitin Sulfate

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Chondroitin Sulfate.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before using Cartiflex if you take warfarin (Coumadin) or any other blood thinner—chondroitin may increase bleeding risk. No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Cartiflex may be worth considering if you're interested in joint support or skin hydration and have no blood-thinning medications in your routine. If you take warfarin or any blood thinner, check with your pharmacist first.

The evidence that this combination works for joint health isn't yet established, and chondroitin isn't recommended in pregnancy or while nursing.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cartiflex, straight from the product label.

Brand Quality of Life
Barcode (UPC) 812259003233
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 299339
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cartiflex by Quality of Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
812259003233
IngredientAmount% DV
Proprietary Blend1200 mg--
Chondroitin Sulfate400 mg--
Hyaluronic Acid100 mg--
BioCell Collagen600 mg--

Other ingredients: Microcrystalline Cellulose, Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

A joint is the place where two bones are connected. The bones are covered with a layer of slippery cartilage, which enables them to glide against each other seamlessly. Unfortunately, through the normal aging process, the cartilage begins to wear out, impairing easy movement.

Formula

Cartiflex features two clinically tested ingredients: BioCell Collagen and chondroitin sulfate. These ingredients have been shown in numerous double-blind, placebo-controlled human clinical trials to: Improve joint flexibility and mobility Help cushion and lubricate the joints Promote a more active daily life

BioCell Collagen is a patented ingredient whose composition is similar to your own joints. In addition to providing highly absorbable hydrolyzed type II collagen peptides (the main type of collagen in joint cartilage), it contains hyaluronic acid (which lubricates the joints) and chondroitin (which supports the matrix structure of cartilage). For even greater benefit, Cartiflex also includes extra chondroitin sulfate.

Cartiflex with Collagen, HA & Chondroitin Made with BioCell Collagen

BioCell Collagen is clinically validated at 2 g daily, providing 400 mg of chondroitin. Stand-alone chondroitin sulfate studies typically use 800 mg/day. Cartiflex combines BioCell Collagen with extra chondroitin to reach the clinically studied dosages of each ingredient.

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Joint Health

Improves joint flexibility & mobility Helps cushion & lubricate the joints Promotes a more active daily life

GF

GMP

This product is gluten-free.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take 2 capsules twice daily with meals.

Brand IP Statement(s)

BioCell Collagen is a registered trademark of BioCell Technology LLC (U.S. Patents 6,025,327; 6,323,319; 6,780,841; 7,091,180; 7,779,348; other U.S. & foreign patents pending).

Precautions

Warning: Do not use if seal is broken or missing.

Keep out of reach of children.

Consult your healthcare professional before use if you are pregnant or lactating, have or had a medical condition, or are taking prescription drugs.

Storage

Store at room temperature.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cartiflex by Quality of Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cartiflex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cartiflex by Quality of Life

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1200 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cartiflex by Quality of Life Drug Interactions

Want to check YOUR meds against Cartiflex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Chondroitin Sulfate 2

Individual Drug Interactions

The ingredients in Cartiflex interact with 2 drugs. Click any drug to see the details.

1 of the 2 ingredients in Cartiflex interact with drugs. Each result below shows which ingredient is responsible. Chondroitin Sulfate

Each ingredient & the kinds of drugs it affects

For each ingredient in Cartiflex with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Chondroitin Sulfate1 drug type · 2 drugs

Warfarin (Coumadin)

Taking chondroitin in combination with glucosamine might increase the anticoagulant effects of warfarin. However, the effect of chondroitin alone is unclear.
There have been multiple reports of increased international normalized ratio (INR) in patients taking warfarin with glucosamine, with or without chondroitin. The lack of reports with chondroitin alone seem to suggest that the interactions occurring in these reports may have been due to glucosamine. In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in INR in patients previously stabilized on warfarin. Additionally, 20 voluntary case reports to the US Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone, without chondroitin, to increased INR in patients taking warfarin.

Likelihood Unlikely Evidence D
Chondroitin Sulfate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cartiflex, from the product label.

Quality of Life

Name
QOL Labs, LLC
City
Purchase
State
NY
ZipCode
10577
Phone Number
(914) 251-0981
Pharmacist Counseling Corner

Cartiflex by Quality of Life: Common Questions

Does Cartiflex by Quality of Life interact with any medications?
Yes. Based on its ingredients, Cartiflex has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cartiflex contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Cartiflex while I'm pregnant?
The safety data advises against chondroitin during pregnancy because there isn't enough information. For hyaluronic acid, we don't have enough data either way. Talk with your doctor or pharmacist before taking this product if you're pregnant or planning to become pregnant.
Can I breastfeed while taking Cartiflex?
The safety data advises against chondroitin while breastfeeding due to lack of safety information. We don't have enough data on hyaluronic acid either. Check with your doctor or pharmacist for personalized advice.
What are the most common side effects?
Chondroitin can cause stomach upset—abdominal pain, bloating, constipation, diarrhea, heartburn, or nausea. Skin symptoms like swelling, rash, or hair loss have also been reported. Most people tolerate it well for short-term use, but quality and benefit vary.
Does this actually work for joint pain?
Chondroitin is possibly effective for osteoarthritis, meaning there's some evidence but it's not definitive. We don't have established evidence in our data that this specific combination works for joint support overall. Talk to your pharmacist about what the research shows for your situation.
What is hyaluronic acid in here for?
Hyaluronic acid is a natural substance that holds water and supports skin and eye moisture. It's possibly effective for dry eye and wound healing, but the evidence for skin aging is insufficient.
Is there any risk if I take this long-term?
Chondroitin is generally well tolerated for short-term use, but long-term safety isn't fully studied for either ingredient. One rare serious side effect (liver damage) has been reported with chondroitin. Talk with your pharmacist about how long you plan to take it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cartiflex label
Go deeper

The Full Monographs Behind Cartiflex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chondroitin Sulfate

Interacts with 2 drugs

Chondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain. The evidence is mixed—some people report...

Read the full Chondroitin Sulfate monograph →
Sources

Sources & How We Checked

Cartiflex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chondroitin Sulfate 22 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam Pract 2002;15:481-4..
  3. Danao-Camara T. Potential side effects of treatment with glucosamine and chondroitin. Arthritis Rheum 2000;43:2853. PubMed
  4. Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. Am J Health Syst Pharm 2004;61:306-307. PubMed
  5. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795-808. DOI
  6. Knudsen J, Sokol GH. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: Case report and review of the literature and MedWatch database. Pharmacotherapy 2008;28:540-8. PubMed
  7. Yue QY, Strandell J, Myrberg O. Concomitant use of glucosamine potentiates the effect of warfarin. Jan 2006. Drug Safety 29(10):911-1010. DOI
  8. Nordling, J. and van, Ophoven A. Intravesical glycosaminoglycan replenishment with chondroitin sulphate in chronic forms of cystitis. A multi-national, multi-centre, prospective observational clinical trial. Arzneimittelforschung. 2008;58(7):328-335. PubMed
  9. Nickel, J. C., Egerdie, B., Downey, J., Singh, R., Skehan, A., Carr, L., and Irvine-Bird, K. A real-life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystit
  10. Oliviero, U., Sorrentino, G. P., De Paola, P., Tranfaglia, E., D'Alessandro, A., Carifi, S., Porfido, F. A., Cerio, R., Grasso, A. M., Policicchio, D., and . Effects of the treatment with matrix on elderly people with chronic articular degeneration. Drug
  11. Crowley, D. C., Lau, F. C., Sharma, P., Evans, M., Guthrie, N., Bagchi, M., Bagchi, D., Dey, D. K., and Raychaudhuri, S. P. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int.J.Med.Sc PubMed
  12. Nickel, J. C., Egerdie, R. B., Steinhoff, G., Palmer, B., and Hanno, P. A multicenter, randomized, double-blind, parallel group pilot evaluation of the efficacy and safety of intravesical sodium chondroitin sulfate versus vehicle control in patients with
  13. Sawitzke, A. D., Shi, H., Finco, M. F., Dunlop, D. D., Harris, C. L., Singer, N. G., Bradley, J. D., Silver, D., Jackson, C. G., Lane, N. E., Oddis, C. V., Wolfe, F., Lisse, J., Furst, D. E., Bingham, C. O., Reda, D. J., Moskowitz, R. W., Williams, H. J.
  14. Wildi, L. M., Raynauld, J. P., Martel-Pelletier, J., Beaulieu, A., Bessette, L., Morin, F., Abram, F., Dorais, M., and Pelletier, J. P. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starti
  15. Pavelka and et al. Double-blind, dose effect study of oral cs 4 & 6 1200mg, 800mg, 200mg against placebo in the treatment of femorotibial osteoarthritis. Wular Rheumatol Liter 1998;27(suppl 2):63.
  16. Cerda C, Bruguera M, Parés A. Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease. World J Gastroenterol 2013;19(32):5381-4. PubMed
  17. von Felden J, Montani M, Kessebohm K, Stickel F. Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate. Int J Clin Pharmacol Ther 2013;51(3):219-23. PubMed
  18. Provenza JR, Shinjo SK, Silva JM, Peron CR, Rocha FA. Combined glucosamine and chondroitin sulfate, once or three times daily, provides clinically relevant analgesia in knee osteoarthritis. Clin Rheumatol 2015;34:1455-62. PubMed
  19. Ossendza RA, Grandval P, Chinoune F, Rocher F, Chapel F, Bernardini D. [Acute cholestatic hepatitis due to glucosamine forte]. Gastroenterol Clin Biol. 2007 Apr;31(4):449-50.
  20. Greenlee H, Crew KD, Shao T, Kranwinkel G, Kalinsky K, Maurer M, Brafman L, Insel B, Tsai WY, Hershman DL. Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer. Support Care Cancer 201 PubMed
  21. Chu EC, Huang KHK, Cheung G, Ng G, Lin A. Delayed Skin Allergy to Glucosamine Chondroitin Supplement. Cureus 2023;15(3):e36310. PubMed
  22. Lila AM, Alekseeva LI, Baranov AA, et al. Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis: A long-term observational study in Russia. World J Orthop 2023;14(6):443-457. PubMed

See these in context on the Chondroitin Sulfate monograph →

Hyaluronic Acid 4 references
  1. Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
  2. U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
  3. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
  4. Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed

See these in context on the Hyaluronic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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