Children's DigestEnz Natural Mixed Berry Ingredients & Drug Interactions
by ProEnzol
What is this page for?
First and foremost: checking Children's DigestEnz Natural Mixed Berry against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Children's DigestEnz Natural Mixed Berry is a dietary supplement by ProEnzol with 16 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Children's DigestEnz Natural Mixed Berry by ProEnzol
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product lists 16 ingredients, and they are digestive enzymes, which are proteins that help break down food. Among them are protease, phytase, lactase, and lipase, which have some data on file, along with many others we hold no monograph for, such as amylase, cellulase, and invertase.
The product is a mixed berry tablet that also contains a group container called Children's DigestEnz Blend, whose component enzymes are listed individually. The inactive ingredients are allulose, tapioca dextrin, pomegranate, acai, malic acid, beet juice, monk fruit extract, magnesium stearate, and silica.
These are not active enzymes, and they are not a complete list of fillers or binders beyond what is shown here.
Does it work?
Strong evidence
The strongest rating in our data belongs to lactase, which is rated Effective for lactose intolerance. Its ratings for prematurity and colic are listed as insufficient reliable evidence to rate.
Phytase and lipase have only insufficient reliable evidence to rate for the conditions listed, including iron deficiency anemia, zinc deficiency, and inflammatory bowel disease. Protease has no effectiveness ratings in our data.
How safe is it?
Well-documented data
Protease is generally well tolerated for most adults, but it may cause digestive upset or allergic reactions. Its safety notes advise avoiding it during pregnancy unless prescribed, and say there is little safety data during breastfeeding, so use is not recommended without medical advice.
In workplaces where powdered enzymes are handled, protease and phytase have been linked to allergic reactions, and a lactase case has been reported with contact dermatitis. Lactase is listed as likely safe in pregnancy, though its safety notes still advise checking with your doctor before regular use.
Phytase's safety data is not sufficient to know either way, and lipase's pregnancy and breastfeeding safety has not been well studied. Please talk with your own doctor or pharmacist about any personal concerns.
Meds to double-check
No known interactions
No interactions are documented in our data for protease, phytase, lactase, or lipase. We hold no interaction data for several other enzymes in this blend, so we cannot check them.
Please check your exact medications with the search tool on this page and confirm with your own doctor or pharmacist before combining this product with any prescription.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.
This product may be of interest to parents who want to know how a digestive enzyme blend is put together, and lactase is the one ingredient with an Effective rating in our data, for lactose intolerance. Parents of children on prescription medicine, anyone who is pregnant or breastfeeding, and anyone with a serious digestive condition should be especially careful.
Please talk it over with your own doctor or pharmacist before giving it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 16 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Children's DigestEnz Natural Mixed Berry, straight from the product label.
| Brand | ProEnzol |
|---|---|
| Barcode (UPC) | 707636121122 |
| Net contents | 180 Vegan Chewable Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2025 |
| DSLD ID | 322817 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Children 4 or More Years of Age, Vegan, Vegetarian, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Children's DigestEnz Natural Mixed Berry by ProEnzol, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Total Carbohydrates | 1 Gram(s) | 1% |
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Total Sugars | 1 Gram(s) | -- |
| Cellulase | 0 NP | -- |
| Peptidase | 0 NP | -- |
| Invertase | 0 NP | -- |
| Glucoamylase | 0 NP | -- |
| Xylanase | 0 NP | -- |
| Pectinase | 0 NP | -- |
| Maltase | 0 NP | -- |
| Beta-Glucanase | 0 NP | -- |
| Phytase | 0 NP | -- |
| Hemicellulase | 0 NP | -- |
| Diastase | 0 NP | -- |
| Alpha-Galactosidase | 0 NP | -- |
| Lactase | 0 NP | -- |
| Children's DigestEnz Blend | 109 mg | -- |
| Lipase | 0 NP | -- |
Other ingredients: Allulose, Tapioca Dextrin, Pomegranate, Acai, Malic Acid, Beet Juice, Natural, Monk Fruit Extract, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
ProEnzol Children's DigestEnz provides an excellent, broad-spectrum blend of acid-resistant, non-animal derived digestive enzymes to assist the body's own enzymes in breaking down and assimilating dietary protein, carbohydrates, fat and fiber, making food nutrients more readily available for optimal absorption.
Natural mixed berry
Suggested/Recommended/Usage/Directions
Directions for children ages 4+: chew one (1) tablet at the beginning of each meal, or as directed by your healthcare professional.
Precautions
Caution: if you are pregnant, nursing, have a serious medical condition, or take any medications, consult your healthcare professional before use.
Use only if tamper-evident seal is unbroken.
Keep out of reach of children.
Storage
Store tightly closed in a cool, dry place.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, mitigate, cure, or prevent any disease.
Formulation
Easy-to-chew digestive support
Contains no: sucrose, fructose, dextrose, sugar alcohols, soy, wheat, yeast, gluten, peanuts, tree nuts, eggs, dairy, animal products, artificial colors, flavors and sweeteners or genetically modified organisms (GMOs).
FDA Statement of Identity
Dietary Supplement
General Statements
Exclusively for professionals
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Children's DigestEnz Natural Mixed Berry by ProEnzol label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Children's DigestEnz Natural Mixed Berry by ProEnzol
These are the 16 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Vegan Chewable Tablet(s) Dosage formTablet Or Pill Servings per container180 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: Allulose, Tapioca Dextrin, Pomegranate, Acai, Malic Acid, Beet Juice, Natural, Monk Fruit Extract, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Children's DigestEnz Natural Mixed Berry by ProEnzol Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Children's DigestEnz Natural Mixed Berry. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Children's DigestEnz Natural Mixed Berry, from the product label.
ProEnzol
See all ProEnzol products- Name
- Enzymes Inc.
- City
- Kansas City
- State
- MO
- ZipCode
- 64153
- Phone Number
- 1-800-637-7893
- Web Address
- www.proenzol.com
Children's DigestEnz Natural Mixed Berry by ProEnzol: Common Questions
Does Children's DigestEnz Natural Mixed Berry by ProEnzol interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is lactase in this product supposed to do?
Is protease okay to give during breastfeeding?
Does lipase work for digestive problems?
Is phytase safe to take during pregnancy?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Children's DigestEnz Natural Mixed Berry is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Children's DigestEnz Natural Mixed Berry’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographPhytase
Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...
Read the full Phytase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph →Sources & How We Checked
Children's DigestEnz Natural Mixed Berry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Phytase 7 references
- Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
- Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
- van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
- Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
- Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
- Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
- Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC