Major interaction on record — check this product against your medications before combining. Based on 5 of 14 ingredients. Check your meds →
Dietary supplement

Children's Probiotic Power Ingredients & Drug Interactions

by Nature's Sunshine

Children's Probiotic Power label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Children's Probiotic Power against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Children's Probiotic Power is a dietary supplement by Nature's Sunshine with 14 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 1,366 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Lactobacillus acidophilus, Bifidobacterium longum, Lactobacillus bulgaricus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Children's Probiotic Power by Nature's Sunshine

Ask about any prescription or over-the-counter medication and we check it for interactions with Children's Probiotic Power by Nature's Sunshine — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Children's Probiotic Power by Nature's Sunshine

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 40 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Whole Food Complex” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Fruit Juice Concentrates” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Children's Probiotic Power contains 40 active and inactive ingredients. The active ingredients include multiple amino acids — L-Arginine, L-Isoleucine, L-Methionine, L-Tyrosine, L-Phenylalanine, L-Valine, L-Threonine, L-Lysine, and L-Cysteine — along with Inositol and Choline Bitartrate.

The product also contains several probiotic bacterial strains: Bifidobacterium infantis, Lactobacillus plantarum, Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus brevis, Bifidobacterium longum, Lactobacillus bulgaricus, Lactobacillus salivarius, and Lactobacillus casei. Plant-based ingredients include White Grape juice concentrate and Acai.

The inactive ingredients are sorbitol, mannitol, xylitol, fructose, FOS, stearic acid, beet root juice concentrate, natural flavor combinations, and magnesium stearate.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive and immune support for children.
  • We looked for evidence on: Abdominal pain, Antibiotic-associated diarrhea, Anxiety, Atopic disease, Atopic dermatitis (eczema), bowel health — and 2 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Inositol is rated "Possibly Ineffective" for Anxiety.
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Ineffective" for Atopic disease.

The evidence data we hold does not establish clear effectiveness for this product as a whole. Individual ingredients show varying evidence levels: L-Tyrosine is possibly effective for cognitive function and memory but possibly ineffective for athletic performance.

L-Lysine is possibly effective for cold sores. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, Helicobacter pylori, antibiotic-associated diarrhea, and bacterial vaginosis.

L-Methionine is possibly effective for neural tube birth defects. Inositol is possibly effective for polycystic ovary syndrome and metabolic syndrome.

White Grape juice concentrate is possibly effective for chronic venous insufficiency. Most other ingredients lack sufficient reliable evidence to establish effectiveness for any condition we hold data on.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Longum Lactobacillus Delbrueckii Bifidobacterium Bifidum Streptococcus Thermophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 26 of the 29 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 28 of 29.
  • General safety write-ups exist for 29 of 29.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Arginine is often well tolerated short-term but can lower blood pressure and may not be safe for everyone; it should be used only under medical supervision. Common side effects include abdominal pain, bloating, nausea, diarrhea, headache, insomnia, and flushing.

L-Methionine is usually safe in food amounts, though high-dose supplements may cause dizziness, drowsiness, low blood pressure, irritability, vomiting, headache, and elevated homocysteine levels. L-Tyrosine is generally well tolerated in healthy adults but should be discussed with a healthcare provider before regular use; common side effects are fatigue, headache, heartburn, and nausea.

L-Phenylalanine is generally tolerated in food amounts but should be used carefully in supplement form and avoided by people with phenylketonuria (PKU); side effects include anxiety, constipation, headache, heartburn, insomnia, nausea, and sedation. The probiotic strains are generally well tolerated in healthy people, though rare cases of bacterial infection have been reported in critically ill or immune-compromised individuals.

Choline is generally safe in food amounts but high-dose supplements can cause fishy body odor, nausea, vomiting, diarrhea, and salivation; the tolerable upper daily limit is 3.5 grams. Apple juice concentrate and Grape juice concentrate are generally well tolerated as food but concentrated supplements are less well studied.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Longum Lactobacillus Delbrueckii Bifidobacterium Bifidum Streptococcus Thermophilus

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 24 of the 29 matched ingredients can interact with medications — Lysine, Asparagus, Apple, Inositol, Strawberry, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium; Parkinson's medications.
  • For scale: 1,367 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before giving this product to your child, double-check with your pharmacist or doctor if they take levodopa (for Parkinson disease) or OATP substrate medications like fexofenadine (Allegra) or atenolol (Tenormin) — these carry the most serious interactions. Also verify use with antihypertensive drugs (blood pressure medications, especially ACE inhibitors and ARBs), blood thinners (anticoagulants or antiplatelets), diabetes medications, thyroid hormones, NMDA antagonists, antibiotic drugs, lithium, or sildenafil (Viagra).

These represent the main drug types affected by ingredients in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is a multi-ingredient probiotic and amino acid blend intended for children. Because it contains multiple ingredients with documented interactions to common medications — particularly levodopa, antihypertensive drugs, blood thinners, diabetes medications, and several others — you should check your child's exact medications before use.

Talk with your pharmacist or doctor, especially if your child takes any prescription drugs, blood pressure medication, blood thinners, or diabetes medicine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 29 of 40 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Children's Probiotic Power, straight from the product label.

Brand Nature's Sunshine
Barcode (UPC) 099904033467
Net contents 90 Chewable Tablet(s)
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 278201
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Gluten Free, Dairy Free, Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Children's Probiotic Power by Nature's Sunshine, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s), 1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s), 1 Tablet(s)
Servings per container
90
UPC/BARCODE
099904033467
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%, 1%
Proprietary Blend0 NP--
L-Leucine0 NP--
L-Arginine0 NP--
L-Isoleucine0 NP--
L-Methionine0 NP--
L-Tyrosine0 NP--
Inositol0 NP--
L-Phenylalanine0 NP--
L-Valine0 NP--
L-Threonine0 NP--
L-Lysine0 NP--
Choline Bitartrate0 NP--
Bifidobacterium infantis0 NP--
Lactobacillus plantarum0 NP--
Lactobacillus acidophilus0 NP--
Lactobacillus rhamnosus0 NP--
Lactobacillus brevis0 NP--
White Grape juice concentrate0 NP--
Bifidobacterium longum0 NP--
Acai0 NP--
Lactobacillus bulgaricus0 NP--
L-Cysteine0 NP--
Lactobacillus salivarius0 NP--
Lactobacillus casei0 NP--
Apple juice concentrate0 NP--
Bifidobacterium bifidum0 NP--
Pear juice concentrate0 NP--
Blueberry juice concentrate0 NP--
Strawberry juice concentrate0 NP--
Streptococcus thermophilus0 NP--
Tomato0 NP--
Cranberry0 NP--
Orange juice concentrate0 NP--
Cherry juice concentrate0 NP--
Pomegranate fruit extract0 NP--
Pineapple juice concentrate0 NP--
Whole Food Complex0 NP--
Spinach0 NP--
Asparagus0 NP--
Carrot0 NP--
Fruit Juice Concentrates0 NP--
MicroNutrients0 NP--
Protector Shield Proprietary Blend100 mg--
Mangosteen0 NP--
Broccoli0 NP--

Other ingredients: Sorbitol, Mannitol, Xylitol, Fructose, FOS, Stearic Acid, Beet root juice concentrate, Natural flavors combinations, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Digestive

Gluten free

Formula

The intestinal tract is home to billions of friendly bacteria that support digestion and bowel health, strengthen immune function and helps keep unfriendly bacteria in check. Antibiotics and poor eating habits can harm these friendly bacteria. Made for kids, chewable Probiotic Power provides 11 species of a billion tiny friends to help repopulate the gut microbiome. It also features the protector shield blend of 17 fruits & veggies for their health benefits, plus fructo-oligosaccharides (aka probiotic fiber) to feed your new friends. Freeze dried for maximum benefits

Chewable probiotic 1 billion CFUs per serving

Suggested/Recommended/Usage/Directions

Recommended use: Children 2 & 3 years of age, chew 1 tablet daily. Children 4 years of age and older, chew 1 tablet twice daily. Chew carefully and thoroughly before swallowing.

Precautions

Warning: Keep out of reach of children.

This bottle was sealed for your protection. Do not use if inner seal is missing or damaged.

Storage: Keep in a cool, dry place, out of reach of children.

This bottle was sealed for your protection. Do not use if inner seal is missing or damaged.

Storage: Keep in a cool, dry place, out of reach of children.

Allergen claims: No gluten, milk, egg, soy, peanut, tree nuts, fish, shellfish.

Storage

Storage: Keep in a cool, dry place, out of reach of children.

Storage: Keep in a cool, dry place, out of reach of children. For best results keep frozen of refrigerated.

FDA Statement of Identity

Children's Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Children's Probiotic Power by Nature's Sunshine label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Children's Probiotic Power label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Children's Probiotic Power by Nature's Sunshine

These are the 14 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

0 NP per serving

Protector Shield Proprietary Blend

100 mg per serving
  • › Whole Food Complex
  • › Fruit Juice Concentrates
  • › MicroNutrients

Other (inactive) ingredients: Sorbitol, Mannitol, Xylitol, Fructose, FOS, Stearic Acid, Beet root juice concentrate, Natural flavors combinations, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Children's Probiotic Power by Nature's Sunshine Drug Interactions

Want to check YOUR meds against Children's Probiotic Power?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,366Drugs
56 Major 1,274 Moderate 36 Minor

Ingredients driving the most interactions

Lactobacillus acidophilus 182
Bifidobacterium longum 182
Lactobacillus bulgaricus 182
Bifidobacterium bifidum 182

Individual Drug Interactions

The ingredients in Children's Probiotic Power interact with 1,366 drugs. Click any drug to see the details.

4 of the 14 ingredients in Children's Probiotic Power interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus Bifidobacterium longum Lactobacillus bulgaricus Bifidobacterium bifidum

Each ingredient & the kinds of drugs it affects

For each ingredient in Children's Probiotic Power with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions

Bifidobacterium longum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum full monograph & interactions

Lactobacillus bulgaricus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L. delbrueckii.
Lactobacillus delbrueckii preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. delbrueckii preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus bulgaricus full monograph & interactions

Bifidobacterium bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Children's Probiotic Power, from the product label.

Nature's Sunshine

See all Nature's Sunshine products
Name
Nature's Sunshine Products, Inc.
City
Spanish Fork
State
UT
ZipCode
84660
Phone Number
(800) 223-8225
Web Address
www.naturessunshine.com
Pharmacist Counseling Corner

Children's Probiotic Power by Nature's Sunshine: Common Questions

Does Children's Probiotic Power by Nature's Sunshine interact with any medications?
Yes. Based on its ingredients, Children's Probiotic Power has a known interaction with 1,366 medications, including 56 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Children's Probiotic Power contains 14 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the probiotics in this product for?
The probiotic strains — including Lactobacillus acidophilus, Bifidobacterium longum, and Lactobacillus bulgaricus — are live beneficial bacteria. Research suggests they may help with digestive health, though evidence varies by strain and condition. Lactobacillus acidophilus, for example, shows possibly effective evidence for irritable bowel syndrome and antibiotic-associated diarrhea.
Is it safe to give this to my child during pregnancy or while breastfeeding?
L-Arginine is rated possibly safe in pregnancy but we don't have enough data for breastfeeding. L-Phenylalanine is rated unsafe in pregnancy, so avoid it then. L-Methionine, L-Cysteine, Choline, Lactobacillus acidophilus, and Bifidobacterium longum are rated possibly safe or likely safe in pregnancy and lactation, but specific pregnancy data for other ingredients aren't on file. Talk with your doctor or pharmacist before use during pregnancy or breastfeeding.
What side effects might happen with this product?
Common side effects from the amino acids include nausea, diarrhea, headache, abdominal pain, and heartburn. L-Arginine may lower blood pressure. The probiotics can cause mild digestive upset like gas and bloating in some people. At very high doses, choline can cause a fishy body odor. Most people tolerate this product well, but side effects depend on individual sensitivity.
Can I give this with antibiotics?
The probiotic bacteria strains in this product — Lactobacillus acidophilus, Bifidobacterium longum, and Lactobacillus bulgaricus — are live organisms that antibiotics can kill. If your child takes antibiotics, separate the probiotic from the antibiotic dose by at least a couple of hours so the beneficial bacteria aren't destroyed by the medication.
Does L-Phenylalanine in this product work for anything?
L-Phenylalanine is rated possibly effective for vitiligo but possibly ineffective for ADHD. We don't have enough evidence to say it works for other conditions in children. Your healthcare provider can discuss whether it's appropriate for your child's specific situation.
What's in the proprietary blend?
The proprietary blend on the label contains the component ingredients listed individually — the amino acids, probiotics, and plant extracts. A proprietary blend means the exact amounts of each ingredient aren't disclosed separately, only the total blend weight. The individual ingredients are still listed so you can check for allergies or interactions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Children's Probiotic Power is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Children's Probiotic Power label
Go deeper

The Full Monographs Behind Children's Probiotic Power’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Lactobacillus Delbrueckii

Interacts with 182 drugs

Lactobacillus delbrueckii is a 'friendly' bacterium used in food fermentation and sold as a probiotic, often as part of multi-strain products. It is generally considered safe for healthy peo...

Read the full Lactobacillus Delbrueckii monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Streptococcus Thermophilus

Streptococcus thermophilus is a friendly bacterium used as a probiotic, often combined with other strains in yogurt and supplements. It is generally well tolerated in healthy people and may...

Read the full Streptococcus Thermophilus monograph →
Sources

Sources & How We Checked

Children's Probiotic Power's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 425 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-arginine 66 references
  1. Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
  2. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
  3. Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9.
  4. Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
  5. Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
  6. Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996;93:2135-41.
  7. Siani A, Pagano E, Iacone R, et al. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens 2000;13:547-51. PubMed
  8. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  9. Wallace AW, Tom WL. Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. Anesth Analg 2000;90:840-6. DOI
  10. Huynh NT, Tayek JA. Oral arginine reduces systemic blood pressure in type 2 diabetes: its potential role in nitric oxide generation. J Am Coll Nutr 2002;21:422-7.. PubMed
  11. Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand 2004;83:103-7.
  12. Resnick DJ, Softness B, Murphy AR, et al. Case report of an anaphylactoid reaction to arginine. Ann Allergy Asthma Immunol 2002;88:67-8. PubMed
  13. Anon. Arginine hydrochloride injection (marketed as R-Gene 10). FDA Drug Safety Newsletter 2009;2(2):16-18. Available at: www.fda.gov/Drugs/DrugSafety/DrugSafetyNewsletter/default.htm.
  14. Higashi Y, Oshima T, Sasaki S, et. al. Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension. Hypertension. 1998 Jul;32(1):16-24.
  15. Facchinetti, F., Longo, M., Piccinini, F., Neri, I., and Volpe, A. L-arginine infusion reduces blood pressure in preeclamptic women through nitric oxide release. J Soc Gynecol.Investig. 1999;6(4):202-207. DOI
  16. de Gouw, H. W., Verbruggen, M. B., Twiss, I. M., and Sterk, P. J. Effect of oral L-arginine on airway hyperresponsiveness to histamine in asthma. Thorax 1999;54(11):1033-1035. PubMed
  17. Komers, R., Komersova, K., Kazdova, L., Ruzickova, J., and Pelikanova, T. Effect of ACE inhibition and angiotensin AT1 receptor blockade on renal and blood pressure response to L-arginine in humans. J Hypertens. 2000;18(1):51-59. PubMed
  18. Cartledge, J. J., Davies, A. M., and Eardley, I. A randomized double-blind placebo-controlled crossover trial of the efficacy of L-arginine in the treatment of interstitial cystitis. BJU.Int. 2000;85(4):421-426.
  19. Sozykin, A. V., Noeva, E. A., Balakhonova, T. V., Pogorelova, O. A., and Men'shikov, M. I. [Effect of L-arginine on platelet aggregation, endothelial function adn exercise tolerance in patients with stable angina pectoris]. Ter.Arkh. 2000;72(8):24-27.
  20. Nagaya, N., Uematsu, M., Oya, H., Sato, N., Sakamaki, F., Kyotani, S., Ueno, K., Nakanishi, N., Yamagishi, M., and Miyatake, K. Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmona
  21. Stokes, G. S., Barin, E. S., Gilfillan, K. L., and Kaesemeyer, W. H. Interactions of L-arginine, isosorbide mononitrate, and angiotensin II inhibitors on arterial pulse wave. Am J Hypertens. 2003;16(9 Pt 1):719-724.
  22. Park, K. G., Heys, S. D., Blessing, K., Kelly, P., McNurlan, M. A., Eremin, O., and Garlick, P. J. Stimulation of human breast cancers by dietary L-arginine. Clin.Sci.(Lond) 1992;82(4):413-417.
  23. Palloshi, A., Fragasso, G., Piatti, P., Monti, L. D., Setola, E., Valsecchi, G., Galluccio, E., Chierchia, S. L., and Margonato, A. Effect of oral L-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension,
  24. Schlaich, M. P., Ahlers, B. A., Parnell, M. M., and Kaye, D. M. beta-Adrenoceptor-mediated, nitric-oxide-dependent vasodilatation is abnormal in early hypertension: restoration by L-arginine. J Hypertens. 2004;22(10):1917-1925. PubMed
  25. Neri, I., Blasi, I., and Facchinetti, F. Effects of acute L-arginine infusion on non-stress test in hypertensive pregnant women. J Matern.Fetal Neonatal Med. 2004;16(1):23-26. PubMed
  26. Rytlewski, K., Olszanecki, R., Korbut, R., and Zdebski, Z. Effects of prolonged oral supplementation with l-arginine on blood pressure and nitric oxide synthesis in preeclampsia. Eur.J Clin.Invest 2005;35(1):32-37.
  27. Mansoor, J. K., Morrissey, B. M., Walby, W. F., Yoneda, K. Y., Juarez, M., Kajekar, R., Severinghaus, J. W., Eldridge, M. W., and Schelegle, E. S. L-arginine supplementation enhances exhaled NO, breath condensate VEGF, and headache at 4,342 m. High Alt.M
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Threonine 4 references
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Lactobacillus Acidophilus 15 references
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  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
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Grape 34 references
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Bifidobacterium Longum 21 references
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Acai 2 references
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  2. de Liz S, Cardoso AL, Copetti CLK, et al. Açaí (Euterpe oleracea Mart.) and juçara (Euterpe edulis Mart.) juices improved HDL-c levels and antioxidant defense of healthy adults in a 4-week randomized cross-over study. Clin Nutr. 2020;39(12):3629-3636. PubMed

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Lactobacillus Delbrueckii 9 references
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  5. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
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L-cysteine 2 references
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Apple 16 references
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Bifidobacterium Bifidum 7 references
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  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
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  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

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Pear 4 references
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See these in context on the Pear monograph →

Blueberry 7 references
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Strawberry 18 references
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Streptococcus Thermophilus 21 references
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Tomato 3 references
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Sweet Orange 17 references
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  13. Deding U, Baatrup G, Christensen LP, Kobaek-Larsen M. Carrot Intake and Risk of Colorectal Cancer: A Prospective Cohort Study of 57,053 Danes. Nutrients 2020;12(2):332. PubMed
  14. Sánchez-Guerrero IM, Nieto A, Meseguer J, et al. Occupational Rhinoconjunctivitis Induced by Unusual Allergens of Carrot. J Investig Allergol Clin Immunol 2020;30(3):204-206. PubMed

See these in context on the Carrot monograph →

Mangosteen 6 references
  1. Chairungsrilerd N, Furukawa K, Ohta T, et al. Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. Planta Med 1996;62:471-2.
  2. Wong LP, Klemmer PJ. Severe lactic acidosis associated with juice of the mangosteen fruit Garcinia mangostana. Am J Kidney Dis 2008;51:829-33. PubMed
  3. Furukawa, K., Chairungsrilerd, N., Ohta, T., Nozoe, S., and Ohizumi, Y. [Novel types of receptor antagonists from the medicinal plant Garcinia mangostana]. Nippon Yakurigaku Zasshi 1997;110 Suppl 1:153P-158P. PubMed
  4. Chairungsrilerd, N., Furukawa, K., Tadano, T., Kisara, K., and Ohizumi, Y. Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha-methyltryptamine-induced head-twitch responses of mice. Br J Pharmacol. 1998
  5. Suthammarak W, Numpraphrut P, Charoensakdi R, et al. Antioxidant-enhancing property of the polar fraction of mangosteen pericarp extract and evaluation of its safety in humans. Oxid Med Cell Longev 2016;2016:1293036. PubMed
  6. Bae M, Han SY, Kim ES, et al. Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice. Molecules 2021;26(17):5246. PubMed

See these in context on the Mangosteen monograph →

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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