CholestOff Plus Ingredients & Drug Interactions
by Nature Made
What is this page for?
First and foremost: checking CholestOff Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
CholestOff Plus is a dietary supplement by Nature Made with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, heart health support, lowering ldl cholesterol.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of CholestOff Plus by Nature Made
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
CholestOff Plus has 2 active ingredients: plant sterols and plant stanols, both derived from plants and designed to help reduce how much cholesterol your body absorbs from food. Plant sterols are the main active component, and both work through the same basic mechanism in your gut.
The softgel also contains inactive ingredients like sunflower oil esters, gelatin, glycerin, medium chain triglycerides, soy lecithin, water, and colors added — these are the capsule material and fillers that hold everything together.
Does it work?
Strong evidence
Plant sterols are likely effective for lowering high cholesterol (hypercholesterolemia) and familial high cholesterol, which is the genetic form. For heart disease prevention, the evidence is a step back — they're possibly effective at helping reduce coronary heart disease risk, meaning the science supports the idea but isn't yet as solid as it is for straightforward cholesterol lowering.
We don't hold effectiveness data for plant stanols on file, so we can't speak to how much it contributes to the product's cholesterol-lowering action.
How safe is it?
Some data gaps
Plant sterols are generally well tolerated at the amounts you'll get from food and supplements in most adults. Pregnancy and breastfeeding safety isn't well studied for concentrated supplements, so talk with your doctor before using this product if you're pregnant or nursing — there isn't enough data to know either way.
In rare cases, people have reported abdominal discomfort, skin rashes, or — in one extreme case of very high dosing — signs of early puberty in a toddler. Because plant sterols lower cholesterol absorption in your gut, there's a theoretical concern about diarrhea or fatty stools, though these haven't shown up in clinical trials.
Meds to double-check
No known interactions
No interactions are documented for the ingredients we could check in CholestOff Plus. We don't hold interaction data for plant stanols, so we can't rule out interactions with that ingredient.
Use the medication checker on this page or confirm with your doctor or pharmacist before you start.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and some safety-information gaps remain.
If your cholesterol is high and you want a plant-based option, plant sterols have solid evidence behind them. Pregnant or nursing women should clear it with their doctor first because concentrated supplement safety data is thin.
Check your medications with the tool on this page or talk to your pharmacist before you start, just to be sure.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 21, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about CholestOff Plus, straight from the product label.
| Brand | Nature Made |
|---|---|
| Barcode (UPC) | 031604027889 |
| Net contents | 100 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Sep 21, 2018 |
| DSLD ID | 179813 |
| Product type | Fat/fatty Acid |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | Nutrient, All Other, Approved Health, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for CholestOff Plus by Nature Made, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 10 Calorie(s) | -- |
| Calories from Fat | 10 Calorie(s) | -- |
| Total Fat | 1 Gram(s) | 2% |
| Plant Sterols and Plant Stanols | 900 mg | -- |
| Plant Sterols | 0 NP | -- |
| Plant Stanols | 0 NP | -- |
Other ingredients: Plant Sterols, Plant Stanols, Sunflower Oil Esters, Gelatin, Glycerin, Medium Chain Triglycerides, Soy Lecithin, Water, Colors added
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Daily sterol & stanol amounts Diet Cholestoff Daily recommended amount Amount of phytosterols The National Institutes of Health (NIH) Therapeutic Lifestyle Change Guidelines Recommends: 2000 mg Many Americans Consume As Little As: - 200 mg CholestOff Plus Provides Additional: 1800 mg Products containing at least 400 mg per serving of plant sterols and stanols, eaten twice a day with meals for a daily intake of at least 800 mg as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease.
Reducol lowers cholesterol by reducing the absorption of dietary cholesterol into the bloodstream.
Before taking CholestOff Plus dietary cholesterol is absorbed into the bloodstream Intestine Bloodstream Intestine wall Cholesterol Plant sterols & stanols Less cholesterol absorbed in the bloodstream After taking CholestOff Plus less dietary cholesterol is absorbed into the bloodstream
Clinically proven to lower cholesterol
100% money back Results guaranteed or your money back. Visit NatureMade.com/guarantee for details.
Formula
One serving of Nature Made CholestOff Plus supplies 900 mg of plant sterols and stanols for a daily intake of 1800 mg.
Nature Made CholestOff Plus is made with esterified Reducol, a proprietary blend of plant-based sterols and stanols (also called phytosterols) which help lower LDL ("bad") cholesterol.
With plant sterols and stanols
Contains: Soy.
General
List No. 2788 P200 Cat. A632 1A160
Brand IP Statement(s)
CholestOff Plus is an easy-to-swallow softgel.
CHOLESTOFF Plus Softgels are made to Nature Made’s guaranteed purity and potency standards.
Reducol Reducol is a trademark of Pharmachem Laboratories Inc.
FDA Statement of Identity
Dietary Supplement
Formulation
Colors derived from natural sources - No synthetic dyes No artificial flavors No preservatives No yeast or starch Gluten free
Suggested/Recommended/Usage/Directions
Suggested use: Take two softgels two times daily with meals. For easier swallowing, take with water before and during ingestion.
Precautions
Caution: Not for use by children or pregnant or lactating women.
Caution: Not for use by children or pregnant or lactating women. Check with your physician before using CholestOff Plus if you are currently using medications to lower your cholesterol.
Store in a cool, dry place out of reach of children.
Do not use if imprinted seal under cap is broken or missing.
Contains: Soy.
Storage
Keep bottle tightly closed. Store in a cool, dry place out of reach of children.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
CholestOff Plus by Nature Made label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in CholestOff Plus by Nature Made
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container50 Amounts shown are per serving.
Plant Sterols and Plant Stanols
No knowninteractions
Plant sterols (and their close relatives, plant stanols) are natural compounds found in plants that can modestly lower LDL ('bad') cholesterol when ta...
Plant Sterols and Plant Stanols monograph & interactions- › Plant Sterols
- › Plant Stanols
Other (inactive) ingredients: Plant Sterols, Plant Stanols, Sunflower Oil Esters, Gelatin, Glycerin, Medium Chain Triglycerides, Soy Lecithin, Water, Colors added. These complete the product’s ingredient list but are not active constituents.
CholestOff Plus by Nature Made Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in CholestOff Plus. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for CholestOff Plus, from the product label.
Nature Made
See all Nature Made products- Name
- Nature Made Nutritional Products
- City
- Mission Hills
- State
- CA
- ZipCode
- 91346-9606
- Phone Number
- 1-800-276-2878
- Web Address
- www.NatureMade.com
CholestOff Plus by Nature Made: Common Questions
Does CholestOff Plus by Nature Made interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will plant sterols actually help lower my cholesterol?
Can I take this if I'm pregnant or breastfeeding?
What side effects should I watch for?
What are plant sterols and plant stanols, anyway?
Does this product have any fillers I should know about?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if CholestOff Plus is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind CholestOff Plus’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
CholestOff Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 3 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Plant Sterols 3 references
- Guardamagna, O., Abello, F., Baracco, V., Federici, G., Bertucci, P., Mozzi, A., Mannucci, L., Gnasso, A., and Cortese, C. Primary hyperlipidemias in children: effect of plant sterol supplementation on plasma lipids and markers of cholesterol synthesis a
- Haque Hussain SS, Weir J, Roberts N. Severe dermatitis secondary to plant sterol supplements. Clin Exp Dermatol. 2009 Oct;34(7):e276-7. PubMed
- Xue P, Wang Y, Chen Y, et al. A Case of Peripheral Precocious Puberty May Be Caused by a Diet Containing Phytosterols in a 20-Month-Old Boy. Horm Res Paediatr 2022;95(5):484-491. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC